{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T18:35:34Z","timestamp":1777142134277,"version":"3.51.4"},"reference-count":10,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Non-linear parameters were computed to assess the extent of spatial organization in the atria in terms of coupling\/synchronization between electrograms recorded in different atrial sites. Recordings of 9 patients suffering from paroxysmal atrial fibrillation were tested during four clinical experimental conditions: sinus rhythm and atrial fibrillation, both before and after isoproterenol infusion, a drug mimicking adrenergic activation. Two non-linear metrics were investigated: an index of non-linear association (NLA) and a synchronization (S) index based on the cross-conditional entropy. Results evidence the presence of reduced coupling after drug infusion in both sinus rhythm and atrial fibrillation. Moreover, passing from the NLA to the S index, the capability of the parameter to capture the subtle changes due to isoproterenol administration increased.<\/jats:p>","DOI":"10.1515\/bmt.2006.051","type":"journal-article","created":{"date-parts":[[2006,10,25]],"date-time":"2006-10-25T08:06:05Z","timestamp":1161763565000},"page":"260-263","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of spatial organization in the atria during paroxysmal atrial fibrillation and adrenergic stimulation"],"prefix":"10.1515","volume":"51","author":[{"given":"Valentina D.A.","family":"Corino","sequence":"first","affiliation":[{"name":"Dipartimento di Bioingegneria, Politecnico di Milano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Mantica","sequence":"additional","affiliation":[{"name":"Electrophysiology Laboratory, S Ambrogio Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Cardiologia, Dipartimento di Medicina, Chirurgia e Odontoiatria, Ospedale San Paolo, University of Milan, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca T.","family":"Mainardi","sequence":"additional","affiliation":[{"name":"Dipartimento di Bioingegneria, Politecnico di Milano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2006,10,25]]},"reference":[{"key":"2026042517510128419_ref1_w2aab2b8c53b1b7b1ab1ab1Aa","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1161\/01.CIR.103.5.769","volume":"103","author":"Alessie","year":"2001","journal-title":"Circulation"},{"key":"2026042517510128419_ref2_w2aab2b8c53b1b7b1ab1ab2Aa"},{"key":"2026042517510128419_ref3_w2aab2b8c53b1b7b1ab1ab3Aa","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1540-8167.1995.tb00416.x","volume":"6","author":"Hoekstra","year":"1995","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2026042517510128419_ref4_w2aab2b8c53b1b7b1ab1ab4Aa","first-page":"2","volume":"8","author":"Jalife","year":"1998","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2026042517510128419_ref5_w2aab2b8c53b1b7b1ab1ab5Aa","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1475-925X-3-37","volume":"3","author":"Mainardi","year":"2004","journal-title":"Biomed Eng Online"},{"key":"2026042517510128419_ref6_w2aab2b8c53b1b7b1ab1ab6Aa","first-page":"183","volume":"140","author":"Moe","year":"1962","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"2026042517510128419_ref7_w2aab2b8c53b1b7b1ab1ab7Aa"},{"key":"2026042517510128419_ref8_w2aab2b8c53b1b7b1ab1ab8Aa"},{"key":"2026042517510128419_ref9_w2aab2b8c53b1b7b1ab1ab9Aa","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s004220050549","volume":"81","author":"Porta","year":"1999","journal-title":"Biol Cybern"},{"key":"2026042517510128419_ref10_w2aab2b8c53b1b7b1ab1ac10Aa","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1111\/j.1540-8159.1994.tb01490.x","volume":"17","author":"Sih","year":"1994","journal-title":"Pacing Clin Electrophysiol"}],"container-title":["bmte"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/BMT.2006.051\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/BMT.2006.051\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T17:51:07Z","timestamp":1777139467000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/BMT.2006.051\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,1]]},"references-count":10,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2006,10,25]]},"published-print":{"date-parts":[[2006,10,1]]}},"alternative-id":["10.1515\/BMT.2006.051"],"URL":"https:\/\/doi.org\/10.1515\/bmt.2006.051","relation":{},"ISSN":["0013-5585","1862-278X"],"issn-type":[{"value":"0013-5585","type":"print"},{"value":"1862-278X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,1]]}}}