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Open angle, chronic glaucoma tends to progress at a slower rate and patients may not notice loss of vision until the disease has progressed significantly. Primary open angle glaucoma (POAG) is described distinctly as a multifactorial optic neuropathy that is chronic and progressive with a characteristic acquired loss of optic nerve fibers. Such loss develops in the presence of open anterior chamber angles, characteristic visual field abnormalities, and IOP that is too high for the healthy eye. It manifests by cupping and atrophy of the optic disc, in the absence of other known causes of glaucomatous disease. Several biological markers have been implicated with the disease. The purpose of this study was to summarize the current knowledge regarding the non-genetic molecular markers which have been predicted to have an association with POAG but have not yet been validated.<\/jats:p>","DOI":"10.1515\/cclm-2012-0048","type":"journal-article","created":{"date-parts":[[2012,9,3]],"date-time":"2012-09-03T12:08:04Z","timestamp":1346674084000},"page":"2107-2119","source":"Crossref","is-referenced-by-count":16,"title":["Biomarkers in primary open angle glaucoma"],"prefix":"10.1515","volume":"50","author":[{"given":"Haris","family":"Kokotas","sequence":"first","affiliation":[{"name":"Department of Genetics, Institute of Child Health,\u2018Aghia Sophia\u2019 Children\u2019s Hospital , Athens , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Kroupis","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Attikon Hospital, Athens University Medical School , Athens , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Chiras","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ioannina University Medical School , Ioannina , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Grigoriadou","sequence":"additional","affiliation":[{"name":"Department of Genetics, Institute of Child Health,\u2018Aghia Sophia\u2019 Children\u2019s Hospital , Athens , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klea","family":"Lamnissou","sequence":"additional","affiliation":[{"name":"Department of Genetics and Biotechnology, Faculty of Biology, University of Athens , Athens , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Genetics, Institute of Child Health,\u2018Aghia Sophia\u2019 Children\u2019s Hospital , Athens , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Kitsos","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ioannina University Medical School , Ioannina , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2012,6,29]]},"reference":[{"key":"2026053121574272020_j_cclm-2012-0048_ref_001","doi-asserted-by":"crossref","unstructured":"Thomassen TL, Perkins ES, Dobree JH. 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