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There is little doubt that hyperhomocysteinemia is associated with several human disorders, such as cardiovascular disease, neurodegenerative disorders, pregnancy complications and fractures, so that its measurement might be useful for risk assessment. Nevertheless, several randomized homocysteine-lowering therapy trials have failed to show that supplementation with vitamins B substantially modifies (and \u2013 more importantly \u2013 improves) the end points and the related outcomes. According to the current state of scientific knowledge, it seems thus reasonable to conclude that lowering homocysteine alone is probably insufficient to mitigate the risk of thromboembolic, cardiovascular and neurodegenerative disorders inasmuch as this bizarre amino acid acts in strict synergy with other probably more powerful risk factors. Several lines of evidence suggest, however, that its measurement may be helpful for identifying subjects at greater risk of disease, who may thus benefit from a more aggressive treatment of other modifiable risk factors, as recently shown by result of the 5-year Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) trial.<\/jats:p>","DOI":"10.1515\/cclm-2012-0372","type":"journal-article","created":{"date-parts":[[2012,6,30]],"date-time":"2012-06-30T23:57:37Z","timestamp":1341100657000},"page":"2075-2080","source":"Crossref","is-referenced-by-count":31,"title":["Hyperhomocysteinemia in health and disease: where we are now, and where do we go from here?"],"prefix":"10.1515","volume":"50","author":[{"given":"Giuseppe","family":"Lippi","sequence":"first","affiliation":[{"name":"Associate Editor of Clinical Chemistry and Laboratory Medicine, Clinical Chemistry and Hematology Laboratory, Academic Hospital of Parma , Parma , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Plebani","sequence":"additional","affiliation":[{"name":"Editor in Chief of Clinical Chemistry and Laboratory Medicine, Department of Laboratory Medicine, University of Padova , Padova , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2012,11,28]]},"reference":[{"key":"2022011514411337462_j_cclm-2012-0372_ref_001","doi-asserted-by":"crossref","unstructured":"McCully KS. 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