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The aim of the meeting was to present and discuss the results of recent studies on the use of HE4 and on the Risk of Ovarian Malignancy Algorithm (ROMA), which combines the results of HE4 and CA 125. The meeting was structured in separate sessions focusing on ovarian cancer risk stratification, differential diagnosis, prognosis and monitoring and with diagnosis and monitoring of endometrial cancer. We present here a summary of the data and evidence, presented, together with consensus statements on the different topics, where available, and suggestions for further studies and evaluations required to establish optimal use of HE4, either alone or in combination with other markers, for diagnostic and prognostic purposes in gynecological malignancies. Available evidences support the utility of this new cancer biomarker for risk stratification, prognosis and monitoring of epithelial ovarian cancer and of endometrial cancer.<\/jats:p>","DOI":"10.1515\/cclm-2012-0373","type":"journal-article","created":{"date-parts":[[2012,7,31]],"date-time":"2012-07-31T20:19:08Z","timestamp":1343765948000},"page":"2127-2136","source":"Crossref","is-referenced-by-count":37,"title":["HE4 in gynecological cancers: report of a European investigators and experts meeting"],"prefix":"10.1515","volume":"50","author":[{"given":"Mario","family":"Plebani","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Padua University-Hospital , Padua , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the HE4 Study Group","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2012,7,25]]},"reference":[{"key":"2022011514432533836_j_cclm-2012-0373_ref_001","doi-asserted-by":"crossref","unstructured":"Kirchhoff C, Habben I, Ivell R, Krull N. 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