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mediated enhancement of permeation requires Ca - signalling in vascular endothelial cells","volume":"30","author":"Tanaka","year":"2003","journal-title":"Clin Exp Pharmacol"},{"key":"ref1211","first-page":"166","article-title":"Abnormal pyridoxine metabolism in toxemia of pregnancy","author":"Kleiger","year":"1969","journal-title":"Ann NY Acad Sci"},{"key":"ref1501","first-page":"587","article-title":"NS Evidence for the role of oxidative stress in acute ischemic heart disease : a brief","volume":"15","author":"Dhalla","year":"1999","journal-title":"review Can J Cardiol"},{"key":"ref331","first-page":"111","article-title":"Alterations in brainstem alpha adrenoreceptor activity in pyridoxine - deficient rat model of hypertension","author":"Viswanathan","year":"1990","journal-title":"Neurosci Lett"},{"key":"ref341","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3109\/10641969309041624","article-title":"Regulation of calcium influx into vascular smooth muscle by vitamin","volume":"15","author":"Lal","year":"1993","journal-title":"Clin Exp Hypertens"},{"key":"ref461","first-page":"1","article-title":"NS RE Intracellular calcium handling in normal and failing hearts","author":"Dhalla","year":"1996","journal-title":"Exp Clin Cardiol"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/ajcn\/57.1.47","article-title":"der and folate nutritional status in men with hyperhomocysteinemia","volume":"12","author":"Ubbink","year":"1993","journal-title":"Vitamin vitamin Am J Clin Nutr"},{"key":"ref481","doi-asserted-by":"crossref","first-page":"3680","DOI":"10.1021\/jm0300678","article-title":"Design and synthesis of novel pyridoxine phosphonates as potential antiischemic agents","author":"Pham","year":"2003","journal-title":"J Med Chem"},{"key":"ref821","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1096\/fasebj.8.3.8143940","article-title":"Modulation of steroid receptor - mediated gene expression by vitamin","volume":"8","author":"Tully","year":"1994","journal-title":"FASEB J"},{"key":"ref1681","first-page":"274","article-title":"inhibition of glucose transport in cardiomyocytes","author":"Fischer","year":"1999","journal-title":"J Biol Chem"},{"key":"ref1231","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/00004872-199603000-00013","article-title":"The effect of vitamin on the systolic blood pressure of rats in various animal models of hypertension","volume":"14","author":"Lal","year":"1996","journal-title":"J Hypertens"},{"key":"ref951","first-page":"179","article-title":"deficiency of vitamin is a plausible molecular basis of the retinopathy of patients with diabetes mellitus","author":"Ellis","year":"1991","journal-title":"Biochem Biophys Res Commun"},{"key":"ref31","first-page":"394","article-title":"Effect of pyridoxine on diabetic patients with peripheral neuropathy Podiatry","volume":"7","author":"Cohen","year":"1984","journal-title":"vitamin Am Assoc"},{"key":"ref1801","first-page":"140","article-title":"conjugation to nuclear corepressor RIP and its role in gene regulation","author":"Tsai","year":"2007","journal-title":"Vitamin Nat Chem Biol"},{"key":"ref851","first-page":"265","article-title":"influences glucocorticoid receptor - dependent gene expression","author":"Allgood","year":"1990","journal-title":"Vitamin J Biol Chem"},{"key":"ref1391","doi-asserted-by":"crossref","first-page":"3680","DOI":"10.1021\/jm0300678","article-title":"Design and synthesis of novel pyridoxine phosphonates as potential antiischemic agents","author":"Pham","year":"2003","journal-title":"J Med Chem"},{"key":"ref451","first-page":"99","article-title":"NS Modification of alterations in cardiac function and sarcoplasmic reticulum by vanadate in ischemic - reperfused rat hearts","author":"Takeda","year":"2005","journal-title":"J Appl Physiol"},{"key":"ref1761","first-page":"265","article-title":"influences glucocorticoid receptor - dependent gene expression","author":"Allgood","year":"1990","journal-title":"Vitamin J Biol Chem"},{"key":"ref1241","first-page":"111","article-title":"Alterations in brainstem alpha adrenoreceptor activity in pyridoxine - deficient rat model of hypertension","author":"Viswanathan","year":"1990","journal-title":"Neurosci Lett"},{"key":"ref1771","first-page":"267","article-title":"modulates transcriptional activation by multiple members of the steroid hormone receptor superfamily","volume":"24","author":"Allgood","year":"1992","journal-title":"Vitamin J Biol Chem"},{"key":"ref1711","first-page":"145","article-title":"ST Purinergic modulation of cardiovascular function in the rat locus coeruleus","author":"Yao","year":"2005","journal-title":"Pharmacol"},{"key":"ref01","first-page":"287","article-title":"KM Vitamins for chronic disease prevention in adults scientific","volume":"26","author":"Fairfield","year":"2002","journal-title":"review Am Med Assoc"},{"key":"ref1731","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1096\/fasebj.8.3.8143940","article-title":"Modulation of steroid receptor - mediated gene expression by vitamin","volume":"8","author":"Tully","year":"1994","journal-title":"FASEB J"},{"key":"ref81","first-page":"259","article-title":"NS Treatment of cardiovascular and related pathologies US Patent","volume":"6","author":"Dhalla","year":"2000"},{"key":"ref321","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/00004872-199603000-00013","article-title":"The effect of vitamin on the systolic blood pressure of rats in various animal models of hypertension","volume":"14","author":"Lal","year":"1996","journal-title":"J Hypertens"},{"key":"ref1201","first-page":"121","article-title":"phosphate and hypertensive disorders of pregnancy","author":"Brophy","year":"1975","journal-title":"Am Obstet"},{"key":"ref521","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/S1053-2498(01)00293-5","article-title":"Pyridoxine improves endothelial function in cardiac transplant recipients Transplant","volume":"20","author":"Miner","year":"2001","journal-title":"Heart Lung"},{"key":"ref861","first-page":"267","article-title":"modulates transcriptional activation by multiple members of the steroid hormone receptor superfamily","volume":"24","author":"Allgood","year":"1992","journal-title":"Vitamin J Biol Chem"},{"key":"ref251","first-page":"689","article-title":"deficiency affects antioxidant defences in rat liver and heart","author":"Cabrini","year":"1998","journal-title":"Vitamin Biochem Mol Biol Int"},{"key":"ref1261","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1139\/y98-078","article-title":"NS Alterations of and induced increase in Ca iin cardiomyocytes from vitamin deficient rats Can","author":"Dakshinamurti","year":"1998","journal-title":"J Physiol Pharmacol"},{"key":"ref991","first-page":"259","article-title":"NS Treatment of cardiovascular and related pathologies US Patent","volume":"6","author":"Dhalla","year":"2000"}],"container-title":["Clinical Chemistry and Laboratory Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/cclm-2012-0553\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T16:49:50Z","timestamp":1745945390000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/cclm-2012-0553\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,1]]},"references-count":150,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1515\/cclm-2012-0553","relation":{},"ISSN":["1437-4331","1434-6621"],"issn-type":[{"value":"1437-4331","type":"electronic"},{"value":"1434-6621","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1,1]]}}}