{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T16:18:01Z","timestamp":1782836281287,"version":"3.54.5"},"reference-count":13,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\n                  <jats:bold>Background:<\/jats:bold> The level of \u03b2<jats:sub>2<\/jats:sub>-microglobulin was generally used to evaluate the renal function in adults. Elevated levels of \u03b2<jats:sub>2<\/jats:sub>-microglobulin were also applied to assess the perinatal situations in neonates and fetuses. The aim of our study was to establish and determine the reference values of fetal serum \u03b2<jats:sub>2<\/jats:sub>-microglobulin in the Chinese and to assess its clinical benefits in abnormal fetuses.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods:<\/jats:bold> Data from 308 normal cord blood samples were obtained to calculate the normal reference values of fetal serum \u03b2<jats:sub>2<\/jats:sub>-microglobulin. According to the equations we obtained, we analyzed the level of \u03b2<jats:sub>2<\/jats:sub>-microglobulin in four case groups: renal malformation, hydrops, cytomegalovirus (CMV) infection and rubella virus (RV) infection.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> In the normal group, the concentration of \u03b2<jats:sub>2<\/jats:sub>-microglobulin decreased with the gestational age, with a mean value of 4.35\u00b10.59 mg\/L. The upper limit of \u03b2<jats:sub>2<\/jats:sub>-microglobulin was calculated as 7.55\u20130.074\u00d7gestational age in weeks. The levels of \u03b2<jats:sub>2<\/jats:sub>-microglobulin were significantly higher in the four case groups than the normal group. For the four groups, the sensitivity is 72.7%, 69.6%, 86.7% and 100%, respectively.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions:<\/jats:bold> Fetal serum \u03b2<jats:sub>2<\/jats:sub>-microglobulin may be used as a predictor to evaluate the situations of fetal diseases.<\/jats:p>","DOI":"10.1515\/cclm-2013-0505","type":"journal-article","created":{"date-parts":[[2013,10,16]],"date-time":"2013-10-16T03:09:11Z","timestamp":1381892951000},"page":"413-417","source":"Crossref","is-referenced-by-count":3,"title":["Reference values of fetal serum \u03b2<sub>2<\/sub>-microglobulin in the Chinese: evaluation of its clinical usefulness"],"prefix":"10.1515","volume":"52","author":[{"given":"Suwei","family":"Hu","sequence":"first","affiliation":[{"name":"Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, P. R. China"},{"name":"Department of Prenatal Diagnosis, Guangdong Women and Children Hospital, Guangzhou, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Prenatal Diagnosis, Guangdong Women and Children Hospital, Guangzhou, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Lu","sequence":"additional","affiliation":[{"name":"Subei People\u2019s Hospital of Jiangsu Province, Clinical Medical School of Yangzhou University, Yangzhou, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Dai","sequence":"additional","affiliation":[{"name":"Subei People\u2019s Hospital of Jiangsu Province, Clinical Medical School of Yangzhou University, Yangzhou, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingqin","family":"Mai","sequence":"additional","affiliation":[{"name":"Department of Prenatal Diagnosis, Guangdong Women and Children Hospital, Guangzhou, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Prenatal Diagnosis, Guangdong Women and Children Hospital, Guangzhou, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Prenatal Diagnosis, Guangdong Women and Children Hospital, Guangzhou, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography, Guangdong Women and Children Hospital, Guangzhou, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfang","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Prenatal Diagnosis, Guangdong Women and Children Hospital, Guangzhou, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2013,10,16]]},"reference":[{"key":"2021071522154302083_j_cclm-2013-0505_ref_001_w2aab3b7c79b1b6b1ab2ab1Aa","doi-asserted-by":"crossref","unstructured":"Nakamuro K, Tanigaki N, Pressman D. Multiple common properties of human beta2-microglobulin and the common portion fragment derived from HL-A antigen molecules. Proc Natl Acad Sci USA 1973;70:2863\u20135.","DOI":"10.1073\/pnas.70.10.2863"},{"key":"2021071522154302083_j_cclm-2013-0505_ref_002_w2aab3b7c79b1b6b1ab2ab2Aa","doi-asserted-by":"crossref","unstructured":"Talal N, Grey HM, Zvaifler N, Michalski JP, Daniels TE. Elevated salivary and synovial fluid beta2-microglobulin in Sjogren\u2019s syndrome and rheumatoid arthritis. 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