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osteoclastogenesis","author":"Sugatani","year":"2011","journal-title":"Blood"},{"key":"ref1011","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/jbmr.1845","article-title":"a regulates osteoclastogenesis by targeting maf musculoaponeurotic fibrosarcoma oncogene homolog","volume":"28","author":"Cheng","year":"2013","journal-title":"J Bone Miner Res"},{"key":"ref1961","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/stem.288","article-title":"regulates protein expression and mesenchymal progenitor cell differentiation","volume":"28","author":"Huang","year":"2010","journal-title":"Stem Cells"},{"key":"ref2071","first-page":"402","article-title":"promotes osteoblast differentiation by modulating Wnt signaling","volume":"27","author":"Wang","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"ref2161","first-page":"141","article-title":"a are involved in bone morphogenetic protein - - induced mouse pre - osteoblast differentiation by targeting 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of DNA methylation in the regulation of the RANKL - OPG system in human bone","author":"Delgado","year":"2012","journal-title":"Epigenetics"},{"key":"ref811","first-page":"402","article-title":"promotes osteoblast differentiation by modulating Wnt signaling","volume":"27","author":"Wang","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"ref1461","doi-asserted-by":"crossref","DOI":"10.1038\/nbt.1685","article-title":"modifications human disease","volume":"28","author":"Portela","year":"2010","journal-title":"Nat Biotechnol"},{"key":"ref1231","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4161\/epi.7.1.18753","article-title":"Role of DNA methylation in the regulation of the RANKL - OPG system in human bone","author":"Delgado","year":"2012","journal-title":"Epigenetics"},{"key":"ref2251","first-page":"114","article-title":"Down - regulation of miR biogenesis by estrogen action contributes to osteoclastic apoptosis","volume":"21","author":"Sugatani","year":"2013","journal-title":"J Cell Biochem"},{"key":"ref1591","first-page":"474","article-title":"ME deacetylases in skeletal development and bone mass maintenance","author":"McGee","year":"2011","journal-title":"Gene"},{"key":"ref2281","first-page":"284","article-title":"Impaired micro pathways diminish osteoclast differentiation and function","author":"Sugatani","year":"2009","journal-title":"RNA J Biol Chem"},{"key":"ref441","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1038\/sj.emboj.7600729","article-title":"Repression of function by TGF beta through recruitment of class II histone deacetylases by","volume":"24","author":"Kang","year":"2005","journal-title":"EMBO J"},{"key":"ref281","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/jcb.20544","article-title":"Induction of osteogenic differentiation of human mesenchymal stem cells by histone deacetylase inhibitors","author":"Cho","year":"2005","journal-title":"J Cell Biochem"},{"key":"ref731","first-page":"107","article-title":"network connecting the miR a a cluster regulates the osteoblast differentiation program","volume":"23","author":"Hassan","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref1571","article-title":"Suberoylanilide hydroxamic acid vorinostat causes bone loss by inhibiting immature osteoblasts","volume":"26","author":"McGee","year":"2011","journal-title":"Bone"},{"key":"ref1261","first-page":"121","article-title":"Disorders of bone remodeling","author":"Feng","year":"2011","journal-title":"Annu Rev"},{"key":"ref1911","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1515\/cclm-2012-0360","article-title":"Identification of circulating microRNAs as biomarkers in cancers : what have we got","author":"Sun","year":"2012","journal-title":"Clin Chem Lab Med"},{"key":"ref321","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1111\/j.1528-1167.2009.02516.x","article-title":"NA Adverse effects of valproate on bone : defining a model to investigate the pathophysiology","author":"Senn","year":"2010","journal-title":"Epilepsia"},{"key":"ref2311","first-page":"464","article-title":"Good The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF alpha Osteoarthritis Cartilage","volume":"13","author":"Jones","year":"2009"},{"key":"ref971","first-page":"378","article-title":"miR regulates nephronectin expression modulating osteoblast differentiation by targeting One","author":"Kahai","year":"2009"},{"key":"ref521","first-page":"1","article-title":"Resveratrol - mediated SIRT interactions with modulate receptor activator of kappaB ligand activation of kappaB signaling and inhibit osteoclastogenesis in bone - derived cells","author":"Shakibaei","year":"2011","journal-title":"J Biol Chem"},{"key":"ref2411","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.diff.2010.09.183","article-title":"AT HI Epigenetic modifiers influence lineage commitment of human bone marrow stromal cells : differential effects of aza - deoxycytidine and trichostatin","volume":"81","author":"Serafi","year":"2011","journal-title":"Differentiation"},{"key":"ref1781","first-page":"1","article-title":"Resveratrol - mediated SIRT interactions with modulate receptor activator of kappaB ligand activation of kappaB signaling and inhibit osteoclastogenesis in bone - derived cells","author":"Shakibaei","year":"2011","journal-title":"J Biol Chem"},{"key":"ref1471","first-page":"371832","article-title":"Physical and functional HAT interplay regulates protein acetylation balance","author":"Peserico","year":"2011","journal-title":"J Biomed Biotechnol"},{"key":"ref741","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/cdd.2010.167","article-title":"orchestrates cell proliferation migration and differentiation in human mesenchymal stem cells","volume":"18","author":"Tom\u00e9","year":"2011","journal-title":"Cell Death Differ"},{"key":"ref1561","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/jbmr.426","article-title":"deacetylase inhibitor MS stimulates bone formation in part by enhancing mediated TNAP transcription","volume":"26","author":"Kim","year":"2011","journal-title":"J Bone Miner Res"},{"key":"ref1491","first-page":"318","article-title":"Switching from repression to activation : microRNAs can up - regulate translation","author":"Vasudevan","year":"2007","journal-title":"Science"},{"key":"ref901","first-page":"141","article-title":"a are involved in bone morphogenetic protein - - induced mouse pre - osteoblast differentiation by targeting distal - less homeobox","author":"Itoh","year":"2009","journal-title":"J Biol Chem"},{"key":"ref801","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/jbmr.377","article-title":"Effects of miR in modulating osteogenic differentiation by specifically downregulating Wnt antagonist","volume":"26","author":"Zhang","year":"2011","journal-title":"J Bone Miner Res"},{"key":"ref931","first-page":"106","article-title":"microRNA regulatory mechanism of osteoblast differentiation","author":"Inose","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref961","first-page":"370","article-title":"Expression of BMP in BMP - stimulated mouse pre - osteoblast differentiation is regulated by microRNA","author":"Itoh","year":"2012","journal-title":"FEBS Lett"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1359\/jbmr.081206","article-title":"Sclerostin antibody treatment increases bone formation bone mass and bone strength in a rat model of postmenopausal osteoporosis","volume":"24","author":"Li","year":"2009","journal-title":"J Bone Miner Res"},{"key":"ref2061","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/jbmr.377","article-title":"Effects of miR in modulating osteogenic differentiation by specifically downregulating Wnt antagonist","volume":"26","author":"Zhang","year":"2011","journal-title":"J Bone Miner Res"},{"key":"ref651","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1515\/cclm-2012-0360","article-title":"Identification of circulating microRNAs as biomarkers in cancers : what have we got","author":"Sun","year":"2012","journal-title":"Clin Chem Lab Med"},{"key":"ref1401","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1359\/jbmr.081206","article-title":"Sclerostin antibody treatment increases bone formation bone mass and bone strength in a rat model of postmenopausal osteoporosis","volume":"24","author":"Li","year":"2009","journal-title":"J Bone Miner Res"},{"key":"ref921","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/jbmr.1604","article-title":"is a negative regulator of osteoblast proliferation differentiation and skeletogenesis through targeting","volume":"27","author":"Kim","year":"2012","journal-title":"J Bone Miner Res"},{"key":"ref2121","first-page":"108","article-title":"suppression of osteonectin in osteoblasts : regulation during differentiation and by canonical Wnt signaling","volume":"29","author":"Kapinas","year":"2009","journal-title":"AM J Cell Biochem"},{"key":"ref601","first-page":"286","article-title":"have opposite effects on osteoclast differentiation","author":"Pham","year":"2011","journal-title":"J Biol Chem"},{"key":"ref1091","article-title":"DNA methylation biomarkers and their utility for solid cancer diagnostics","volume":"21","author":"Heichman","year":"2012","journal-title":"Clin Chem Lab Med"},{"key":"ref2391","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1006\/cbir.1998.0240","article-title":"Modulation of osteogenic differentiation in human skeletal cells in Vitro by azacytidine","volume":"22","author":"Locklin","year":"1998","journal-title":"Cell Biol Int"},{"key":"ref2111","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/jbmr.1798","article-title":"Tumor necrosis factor \u03b1 suppresses the mesenchymal stem cell osteogenesis promoter miR in estrogen deficiency - induced osteoporosis","volume":"21","author":"Yang","year":"2013","journal-title":"J Bone Miner Res"},{"key":"ref1661","first-page":"521","article-title":"controls bone mass by - dependent attenuation of activity","author":"Hesse","year":"2010","journal-title":"J Cell Biol"},{"key":"ref161","first-page":"77","article-title":"Estrogen receptor dependent gene expression by osteoblasts direct indirect circumspect and speculative effects","author":"Centrella","year":"2012","journal-title":"Steroids"},{"key":"ref41","first-page":"112","article-title":"of BMP and notch signaling pathways in osteoblast differentiation","author":"Lin","year":"2011","journal-title":"Integration J Cell Biochem"},{"key":"ref1821","first-page":"175","article-title":"Inhibition of histone deacetylase suppresses osteoclastogenesis and bone destruction by inducing IFN - beta production","volume":"16","author":"Nakamura","year":"2005","journal-title":"J Immunol"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/ar2655","article-title":"Developments in the scientific understanding of osteoarthritis","volume":"11","author":"Abramson","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"ref1411","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/jbmr.173","article-title":"Single dose placebo controlled randomized study of a sclerostin monoclonal antibody","volume":"26","author":"Padhi","year":"2011","journal-title":"J Bone Miner Res"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrd3705","article-title":"to bedside : elucidation of the OPG - RANK pathway and the development of denosumab","volume":"11","author":"Lacey","year":"2012","journal-title":"Nat Rev Drug Discov"},{"key":"ref1271","first-page":"174","article-title":"physical mechanism for coupling bone resorption and formation in adult human bone","author":"Andersen","year":"2009","journal-title":"Am J Pathol"},{"key":"ref191","first-page":"105","article-title":"ER CM gene expression","author":"Gibney","year":"2010","journal-title":"Epigenetics Heredity"},{"key":"ref1431","first-page":"244","article-title":"Burgers Regulation of Wnt \u03b2 - catenin signaling within and from osteocytes","author":"TA","year":"2013","journal-title":"Bone"},{"key":"ref2271","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/jbmr.1845","article-title":"a regulates osteoclastogenesis by targeting maf musculoaponeurotic fibrosarcoma oncogene homolog","volume":"28","author":"Cheng","year":"2013","journal-title":"J Bone Miner Res"},{"key":"ref2181","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/jbmr.1604","article-title":"is a negative regulator of osteoblast proliferation differentiation and skeletogenesis through targeting","volume":"27","author":"Kim","year":"2012","journal-title":"J Bone Miner Res"},{"key":"ref701","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/stem.288","article-title":"regulates protein expression and mesenchymal progenitor cell differentiation","volume":"28","author":"Huang","year":"2010","journal-title":"Stem Cells"},{"key":"ref2021","first-page":"3960","article-title":"regulatory feedback loop during mouse osteoblast differentiation","author":"Hu","year":"2011","journal-title":"J Biol Chem"},{"key":"ref2201","first-page":"208","article-title":"modulates BMP - stimulated mouse preosteoblast differentiation by directly targeting ets erythroblastosis virus homolog","volume":"26","author":"Itoh","year":"2010","journal-title":"oncogene J Biol Chem"},{"key":"ref2431","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1002\/jbmr.1491","article-title":"DNA methylation contributes to the regulation of sclerostin expression in human osteocytes","volume":"27","author":"Delgado","year":"2012","journal-title":"J Bone Miner Res"},{"key":"ref1041","first-page":"223","article-title":"is a key factor in osteoclast differentiation","author":"Sugatani","year":"2007","journal-title":"J Cell Biochem"},{"key":"ref111","first-page":"23","article-title":"Marc and the influence of pro - inflammatory cytokines on osteoclasts Zagreb","author":"Zupan","year":"2013","journal-title":"Osteoimmunology Biochem Med"},{"key":"ref1051","first-page":"464","article-title":"Good The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF alpha Osteoarthritis Cartilage","volume":"13","author":"Jones","year":"2009"},{"key":"ref1841","first-page":"275","article-title":"MS a benzamide histone deacetylase inhibitor prevents osteoclastogenesis by down - regulating c Fos expression and suppresses bone loss in mice","author":"Kim","year":"2012","journal-title":"Eur J Pharmacol"},{"key":"ref1991","first-page":"107","article-title":"network connecting the miR a a cluster regulates the osteoblast differentiation program","volume":"23","author":"Hassan","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref171","first-page":"244","article-title":"Burgers Regulation of Wnt \u03b2 - catenin signaling within and from osteocytes","author":"TA","year":"2013","journal-title":"Bone"},{"key":"ref381","first-page":"1","article-title":"mediates HDAC - dependent transcriptional repression of osteocalcin expression during osteoblast differentiation","author":"Choo","year":"2009","journal-title":"Bone"},{"key":"ref461","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/me.2006-0061","article-title":"deacetylase mediated histone modification regulates osteoblast differentiation","volume":"20","author":"Lee","year":"2006","journal-title":"Mol Endocrinol"},{"key":"ref531","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jbmr.1824","article-title":"Silent information regulator Sir inhibits \u03baB signaling to maintain normal skeletal remodeling","volume":"28","author":"Edwards","year":"2013","journal-title":"J Bone Miner Res"},{"key":"ref1361","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1210\/er.2007-0014","article-title":"Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease","volume":"29","author":"Kearns","year":"2008","journal-title":"Endocr Rev"},{"key":"ref891","first-page":"138","article-title":"regulates osteogenic differentiation of human stromal mesenchymal stem cells in vivo","author":"Eskildsen","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref421","first-page":"11492","article-title":"deacetylase depletion in osteo \/ chondroprogenitor cells decreases bone density and increases marrow fat One","author":"Razidlo","year":"2010"},{"key":"ref1311","article-title":"de ten Chapter Signal transduction cascades controlling osteoblast differentiation In editor Primer on the metabolic bone diseases and disorders of mineral metabolism th ed Washington","volume":"10","author":"Krause","year":"2009"},{"key":"ref1881","first-page":"1199","article-title":"Twenty bone - mineral - density loci identified by large - scale meta - analysis of genome - wide association studies","author":"Rivadeneira","year":"2009","journal-title":"Nat Genet"},{"key":"ref821","first-page":"142","article-title":"promotes osteoblast differentiation by modulating Wnt signaling","author":"Hu","year":"2013","journal-title":"Mol Med Rep"},{"key":"ref1191","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jsbmb.2004.02.005","article-title":"del Methylation analysis of the promoter F of estrogen receptor alpha gene : effects on the level of transcription on human osteoblastic cells","author":"Penolazzi","year":"2004","journal-title":"J Steroid Biochem Mol Biol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nrrheum.2011.23","article-title":"Advances in osteoclast biology : old findings and new insights from mouse models","author":"Edwards","year":"2011","journal-title":"Nat Rev Rheumatol"},{"key":"ref341","first-page":"277","article-title":"Histone acetylation in vivo at the osteocalcin locus is functionally linked to vitamin dependent bone tissue - specific 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