{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T11:49:33Z","timestamp":1785239373922,"version":"3.55.0"},"reference-count":122,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Trauma patients sustaining abdominal trauma exhibit high risk of organ failure and\/or sepsis aggravating morbidity and mortality during the post-traumatic course. The present study re-evaluates L- and I-FABPs (small fatty acid binding proteins) as early biomarkers for abdominal injury (AI) in a large cohort of patients and analyzes their potential as indicators of specific organ failure and their association with sepsis and\/or mortality in the post-traumatic course.<\/jats:p><jats:p>This prospective study included 134 multiply traumatized patients (ISS\u226516). Fifty-nine had AI (abbreviated AI Scale, AIS<\/jats:p><jats:p>Median L- and I-FABP in the AI-group [258 (IQR=71\u2013500) ng\/mL and 328 (IQR=148\u2013640) pg\/mL, respectively] were higher compared to noAI-group [30 (IQR=18\u201350) ng\/mL and 60 (IQR=40\u2013202) pg\/mL, p&gt;0.05] on d0. Sensitivity and specificity to detect AI were 80% and 75% for L-FABP, 78% and 62% for I-FABP. Both FABPs decline with the post-traumatic course to control levels. On d0 and d1, FABPs correlate with the Sepsis-related Organ Failure Assessment (SOFA) score of the following day (d0:<\/jats:p><jats:p>Our results confirm the potential of L- and I-FABP to indicate abdominal injuries initially after trauma. Except L-FABP as indicator of acute kidney failure both FABPs have to be further evaluated as predictors for other organ failures, sepsis and\/or mortality.<\/jats:p>","DOI":"10.1515\/cclm-2014-0354","type":"journal-article","created":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T17:01:15Z","timestamp":1413306075000},"source":"Crossref","is-referenced-by-count":24,"title":["I-FABP and L-FABP are early markers for abdominal injury with limited prognostic value for secondary organ failures in the post-traumatic course"],"prefix":"10.1515","volume":"53","author":[{"given":"Maika","family":"Voth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Holzberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Auner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Henrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo","family":"Marzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borna","family":"Relja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref1371","first-page":"284","article-title":"Urinary liver - 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