{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T00:12:43Z","timestamp":1793664763949,"version":"4.5.1"},"reference-count":46,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of our work was to assess the diagnostic contribution of calprotectin and lactoferrin determinations in the cerebrospinal fluid when distinguishing between bacterial and aseptic meningitides.<\/jats:p><jats:p>In 23 patients with bacterial meningitis (BM) and in 50 patients with aseptic meningitis (AM), we determined the concentrations of calprotectin, lactoferrin and the conventional biomarkers like glucose, total protein, lactate and polynuclear count in the cerebrospinal fluid (CSF). The discriminative power of the various parameters studied was determined by means of receiver operating characteristic (ROC) curves: the area under the curve (AUC), sensitivity, specificity, the positive likelihood ratio (+LR), and the negative likelihood ratio (\u2013LR).<\/jats:p><jats:p>The diagnostic efficiency of calprotectin, lactoferrin, lactate, and polynuclear count when distinguishing between bacterial and aseptic meningitides, expressed by ROC curve parameters, was as follows: AUC (0.736, 0.946, 0.932, 0.932), sensitivity (86.2, 96.6, 90.0, 89.7), specificity (58.5, 92.4, 87.0, 90.6), +LR (2.08, 12.8, 6.9, 9.50), \u2013LR (0.24, 0.04, 0.11, 0.11), respectively. The optimal cut point for calprotectin and lactoferrin was 191 ng\/mL and 17.8 ng\/mL, respectively.<\/jats:p><jats:p>Our findings show, that the determination of lactoferrin in the CSF was diagnostically the most efficient marker in distinguishing between bacterial and viral meningitides. Calprotectin was far less efficient diagnostic marker. The polynuclear count and lactate concentration showed a very good diagnostic efficiency as well. The determination of protein and glucose was diagnostically less beneficial.<\/jats:p>","DOI":"10.1515\/cclm-2014-0775","type":"journal-article","created":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T11:55:15Z","timestamp":1416311715000},"source":"Crossref","is-referenced-by-count":11,"title":["Calprotectin and lactoferrin in the cerebrospinal fluid; biomarkers utilisable for differential diagnostics of bacterial and aseptic meningitis?"],"prefix":"10.1515","volume":"53","author":[{"given":"Milan","family":"Dastych","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Gottwaldov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zdenka","family":"\u010cerm\u00e1kov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref191","doi-asserted-by":"crossref","first-page":"687","DOI":"10.3109\/00365549109024294","article-title":"Calprotectin in cerebrospinal fluid of the HIV infected : a diagnostic marker of opportunistic central nervous system infection","volume":"23","author":"Dunlop","year":"1991","journal-title":"Scand J Infect Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/cc10254","article-title":"Meningitis in adult patients with a negative direct cerebrospinal fluid examination : value of cytochemical markers for differential diagnosis","volume":"15","author":"Viallon","year":"2011","journal-title":"Crit Care"},{"key":"ref451","first-page":"216","article-title":"Calprotectin levels in the cerebrospinal fluid reflect disease aktivity in multiple sclerosis","author":"Berg","year":"2009"},{"key":"ref61","first-page":"59","article-title":"AS lactate level : a useful diagnostic tool to differentiate acute bacterial and viral meningitis","volume":"11","author":"Abro","year":"2009","journal-title":"Med Assoc"},{"key":"ref171","article-title":"OF EV TV Level of lactoferrin in serum and cerebrospinal fluid of patients with meningitis","author":"Lykova","year":"2007","journal-title":"Epidemiol"},{"key":"ref401","article-title":"OF EV TV Level of lactoferrin in serum and cerebrospinal fluid of patients with meningitis","author":"Lykova","year":"2007","journal-title":"Epidemiol"},{"key":"ref221","first-page":"216","article-title":"Calprotectin levels in the cerebrospinal fluid reflect disease aktivity in multiple sclerosis","author":"Berg","year":"2009"},{"key":"ref01","first-page":"343","article-title":"The clinical and laboratory diagnosis of acute meningitis and acute encephalitis Expert","author":"Cunha","year":"2013","journal-title":"Med"},{"key":"ref81","first-page":"83","article-title":"Role of calprotectin in infection and inflammation","volume":"16","author":"Dhas","year":"2012","journal-title":"Curr Pediatr Res"},{"key":"ref151","first-page":"665","article-title":"New insights into the biological significance of fecal calprotectin in inflammatory bowel disease","volume":"28","author":"Amati","year":"2006"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1248\/bpb.26.753","article-title":"an inflammatory protein complex from neutrophils with a broad apoptosis - 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