{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:29:41Z","timestamp":1790735381036,"version":"4.1.0"},"reference-count":144,"publisher":"Walter de Gruyter GmbH","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vitamin B<\/jats:p>","DOI":"10.1515\/cclm-2014-0784","type":"journal-article","created":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T17:01:10Z","timestamp":1417626070000},"source":"Crossref","is-referenced-by-count":93,"title":["A review of the cut-off points for the diagnosis of vitamin B12 deficiency in the general population"],"prefix":"10.1515","volume":"53","author":[{"given":"Raquel","family":"Aparicio-Ugarriza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Palacios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Alder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Gonz\u00e1lez-Gross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref1381","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1093\/ajcn\/68.2.328","article-title":"van de van Role of cobalamin intake and atrophic gastritis in mild cobalamin deficiency in older Dutch subjects","author":"Asselt","year":"1998","journal-title":"Am J Clin Nutr"},{"key":"ref1321","first-page":"49","article-title":"for serum holotranscobalamin : method evaluation in the clinical laboratory and reference interval","author":"Loikas","year":"2003","journal-title":"Clin Chem"},{"key":"ref131","first-page":"201","article-title":"Current hematological findings in cobalamin deficiency study of consecutive patients with documented cobalamin deficiency","author":"Andres","year":"2006","journal-title":"Clin Lab Haematol"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.numecd.2011.10.001","article-title":"homocysteine status in an Italian blood donor population","volume":"12","author":"Zappacosta","year":"2013","journal-title":"vitamin Nutr Metab Cardiovasc Dis"},{"key":"ref271","doi-asserted-by":"crossref","DOI":"10.1093\/ajcn\/81.6.1372","article-title":"Factor cobalamin deficiencies and hyperhomocysteinemia in Bangladesh","author":"Gamble","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"ref531","first-page":"49","article-title":"for serum holotranscobalamin : method evaluation in the clinical laboratory and reference interval","author":"Loikas","year":"2003","journal-title":"Clin Chem"},{"key":"ref1191","first-page":"30","article-title":"Prevalence of low serum folate and in an older Australian population","volume":"12","author":"Flood","year":"2006","journal-title":"vitamin J Public Health"},{"key":"ref501","first-page":"105","article-title":"Cobalamin - responsive disorders in the ambulatory care setting : unreliability of cobalamin methylmalonic acid and homocysteine testing","author":"Solomon","year":"2005","journal-title":"Blood"},{"key":"ref1231","first-page":"123","article-title":"High prevalences of vitamin folic acid deficiency in elderly subjects in","volume":"12","author":"Figlin","year":"2003"},{"key":"ref861","first-page":"560","article-title":"Psychiatric manifestations of vitamin deficiency a case report","volume":"29","author":"Durand","year":"2003","journal-title":"Encephale"},{"key":"ref1011","article-title":"Holotranscobalamin as a predictor of vitamin status","volume":"12","author":"Hvas","year":"2003","journal-title":"Clin Chem Lab Med"},{"key":"ref1511","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1080\/07315724.1996.10718611","article-title":"Vitamin supplementation and other variables affecting serum homocysteine and methylmalonic acid concentrations in elderly men and women","volume":"15","author":"Koehler","year":"1996","journal-title":"J Am Coll Nutr"},{"key":"ref941","first-page":"165","article-title":"de Oral cyanocobalamin supplementation in older people with vitamin deficiency a dose - finding trial","author":"Eussen","year":"2005","journal-title":"Arch Intern Med"},{"key":"ref881","first-page":"77","article-title":"for folate deficiency in older persons","volume":"12","author":"Clarke","year":"2003","journal-title":"Screening vitamin Am J Clin Nutr"},{"key":"ref791","first-page":"77","article-title":"vitamins and homocysteine in Spanish institutionalized elderly","author":"Gonzalez","year":"2007","journal-title":"Int J Vitam Nutr Res"},{"key":"ref1171","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0009-9120(00)00083-7","article-title":"JG DE An Ontario - wide study of vitamin serum folate and red cell folate levels in relation to plasma homocysteine : is a preventable public health issue on the rise","volume":"12","author":"Ray","year":"2000","journal-title":"Clin Biochem"},{"key":"ref1201","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1046\/j.1365-2362.2000.00746.x","article-title":"Role of homocysteine cystathionine and methylmalonic acid measurement for diagnosis of vitamin deficiency in high - aged subjects","volume":"30","author":"Herrmann","year":"2000","journal-title":"Eur J Clin Invest"},{"key":"ref1421","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/clinchem\/45.2.189","article-title":"Cobalamin deficiency in general practice Assessment of the diagnostic utility and cost - benefit analysis of methylmalonic acid determination in relation to current diagnostic strategies","author":"Holleland","year":"1999","journal-title":"Clin Chem"},{"key":"ref921","first-page":"201","article-title":"Current hematological findings in cobalamin deficiency study of consecutive patients with documented cobalamin deficiency","author":"Andres","year":"2006","journal-title":"Clin Lab Haematol"},{"key":"ref621","first-page":"132","article-title":"de la The Chilean flour folic acid fortification program reduces serum homocysteine levels and masks vitamin deficiency in elderly people","author":"Hirsch","year":"2002","journal-title":"J Nutr"},{"key":"ref681","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1046\/j.1365-2362.1999.00446.x","article-title":"Holotranscobalamin a sensitive marker of cobalamin malabsorption","volume":"29","author":"Lindgren","year":"1999","journal-title":"Eur J Clin Invest"},{"key":"ref1331","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/ajcn\/74.2.233","article-title":"Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian","author":"Refsum","year":"2001","journal-title":"Am J Clin Nutr"},{"key":"ref1471","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1046\/j.1365-2362.1999.00446.x","article-title":"Holotranscobalamin a sensitive marker of cobalamin malabsorption","volume":"29","author":"Lindgren","year":"1999","journal-title":"Eur J Clin Invest"},{"key":"ref631","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/clinchem\/45.2.189","article-title":"Cobalamin deficiency in general practice Assessment of the diagnostic utility and cost - benefit analysis of methylmalonic acid determination in relation to current diagnostic strategies","author":"Holleland","year":"1999","journal-title":"Clin Chem"},{"key":"ref711","first-page":"53","article-title":"Detection of vitamin deficiency in older people by measuring vitamin or the active fraction of vitamin holotranscobalamin","volume":"12","author":"Clarke","year":"2007","journal-title":"Clin Chem"},{"key":"ref1501","first-page":"53","article-title":"Detection of vitamin deficiency in older people by measuring vitamin or the active fraction of vitamin holotranscobalamin","volume":"12","author":"Clarke","year":"2007","journal-title":"Clin Chem"},{"key":"ref561","first-page":"132","article-title":"CD Cellular folate vitamer distribution during and after correction of vitamin deficiency a case for the methylfolate trap","author":"Smulders","year":"2006"},{"key":"ref1401","first-page":"255","article-title":"UK deficiency neurological syndromes correlation of clinical cognitive evoked potential","author":"Kalita","year":"2008","journal-title":"Vitamin J Neurol"},{"key":"ref1281","first-page":"85","article-title":"MS status in relation to anemia macrocytosis and cognitive impairment in older Americans in the age of folic acid fortification","volume":"12","author":"Morris","year":"2007","journal-title":"vitamin Am J Clin Nutr"},{"key":"ref221","article-title":"Holotranscobalamin as a predictor of vitamin status","volume":"12","author":"Hvas","year":"2003","journal-title":"Clin Chem Lab Med"},{"key":"ref291","first-page":"124","article-title":"Effectiveness of the National Program of Complementary Feeding for older adults in Chile on vitamin status in older adults ; secondary outcome analysis from the CENEX Study","volume":"12","author":"Sanchez","year":"2013","journal-title":"Nutr J"},{"key":"ref1311","article-title":"homocysteine status and chromosome damage rate in lymphocytes of older men","volume":"12","author":"Fenech","year":"1997","journal-title":"vitamin Carcinogenesis"},{"key":"ref1361","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3343\/kjlm.2010.30.2.185","article-title":"Relationship between the levels of holotranscobalamin and","volume":"12","author":"Woo","year":"2010","journal-title":"vitamin Korean J Lab Med"},{"key":"ref1181","first-page":"231","article-title":"The limited value of methylmalonic acid homocysteine and holotranscobalamin in the diagnosis of early deficiency","volume":"12","author":"Goringe","year":"2006","journal-title":"Haematologica"},{"key":"ref91","first-page":"77","article-title":"for folate deficiency in older persons","volume":"12","author":"Clarke","year":"2003","journal-title":"Screening vitamin Am J Clin Nutr"},{"key":"ref981","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1046\/j.1532-5415.2002.50155.x","article-title":"Screening for cobalamin deficiency in geriatric outpatients : prevalence and influence of synthetic cobalamin intake","volume":"30","author":"Rajan","year":"2002","journal-title":"J Am Geriatr Soc"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1093\/ajcn\/58.4.468","article-title":"den Metabolic evidence that deficiencies of vitamin cobalamin folate occur commonly in elderly people","volume":"12","author":"Joosten","year":"1993","journal-title":"vitamin Am J Clin Nutr"},{"key":"ref451","first-page":"776","article-title":"von KM KP ER DR polymorphism negatively affects metabolism","volume":"12","author":"Castel","year":"2005","journal-title":"vitamin Am J Clin Nutr"},{"key":"ref1521","first-page":"772","article-title":"cobalamin and folate status and their relations to neurocognitive and psychological markers in elderly in Northeasten of Iran Iran Basic","volume":"16","author":"Manavifar","year":"2013","journal-title":"Med Sci"},{"key":"ref521","article-title":"homocysteine status and chromosome damage rate in lymphocytes of older men","volume":"12","author":"Fenech","year":"1997","journal-title":"vitamin Carcinogenesis"},{"key":"ref341","first-page":"82","article-title":"Efficacy of a day oral cyanocobalamin supplementation on vitamin B status in Spanish institutionalized elderly","volume":"28","author":"Albers","year":"2012","journal-title":"Int J Vitam Nutr Res"},{"key":"ref991","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1515\/CCLM.2004.109","article-title":"Clinical utility of serum holotranscobalamin as a marker of cobalamin status in elderly patients with neuropsychiatric symptoms","volume":"42","author":"Nilsson","year":"2004","journal-title":"Clin Chem Lab Med"},{"key":"ref1151","first-page":"346","article-title":"Effects of vitamin folate supplements in elderly people with normal serum vitamin concentrations","volume":"12","author":"Naurath","year":"1995","journal-title":"vitamin Lancet"},{"key":"ref1071","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1093\/ageing\/afg109","article-title":"folate deficiency in later life","volume":"12","author":"Clarke","year":"2004","journal-title":"Vitamin Age Ageing"},{"key":"ref1241","first-page":"776","article-title":"von KM KP ER DR polymorphism negatively affects metabolism","volume":"12","author":"Castel","year":"2005","journal-title":"vitamin Am J Clin Nutr"},{"key":"ref1531","first-page":"77","article-title":"Hyperhomocysteinemia - deficiency in elderly using Title IIIc nutrition services","volume":"20","author":"Johnson","year":"2003","journal-title":"vitamin Am J Clin Nutr"},{"key":"ref461","article-title":"Reduction of plasma homocysteine and serum methylmalonate concentrations in apparently healthy elderly subjects after treatment with folic acid a randomised trial","volume":"12","author":"Lewerin","year":"2003","journal-title":"vitamin vitamin Eur J Clin Nutr"},{"key":"ref381","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0009-9120(00)00083-7","article-title":"JG DE An Ontario - wide study of vitamin serum folate and red cell folate levels in relation to plasma homocysteine : is a preventable public health issue on the rise","volume":"12","author":"Ray","year":"2000","journal-title":"Clin Biochem"},{"key":"ref1301","first-page":"5","article-title":"Vitamin status and cognitive function in a long - term care population","author":"Paulionis","year":"2005"},{"key":"ref1041","first-page":"204","article-title":"High prevalence of cobalamin deficiency in elderly outpatients","author":"Pennypacker","year":"1992","journal-title":"J Am Geriatr Soc"},{"key":"ref1341","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1093\/ajcn\/63.3.306","article-title":"rd Relations of vitamin folate homocysteine to cognitive performance in the Normative Study","volume":"12","author":"Riggs","year":"1996","journal-title":"vitamin Aging Am J Clin Nutr"},{"key":"ref761","first-page":"172","article-title":"homocysteine and carotid plaque in the era of folic acid fortification of enriched cereal grain products","volume":"12","author":"Robertson","year":"2005","journal-title":"Vitamin"},{"key":"ref111","first-page":"1999","article-title":"Biochemical indicators of B vitamin status in the US population after folic acid fortification : results from the National Health and Nutrition Examination Survey","author":"Pfeiffer","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"ref1451","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1373\/clinchem.2003.021717","article-title":"status in the elderly as judged by available biochemical markers","volume":"12","author":"Obeid","year":"2004","journal-title":"Vitamin Clin Chem"},{"key":"ref1551","first-page":"172","article-title":"homocysteine and carotid plaque in the era of folic acid fortification of enriched cereal grain products","volume":"12","author":"Robertson","year":"2005","journal-title":"Vitamin"},{"key":"ref781","first-page":"77","article-title":"measures a cross sectional examination","volume":"12","author":"Tangney","year":"2011","journal-title":"Vitamin cognition brain Neurology"},{"key":"ref1141","doi-asserted-by":"crossref","DOI":"10.1373\/clinchem.2003.021634","article-title":"Facts and recommendations about total homocysteine determinations : an expert opinion","volume":"50","author":"Refsum","year":"2004","journal-title":"Clin Chem"},{"key":"ref101","first-page":"1","article-title":"impact of folate deficiency","volume":"12","author":"Gonzalez","year":"2005","journal-title":"Health vitamin b Med"},{"key":"ref1571","first-page":"77","article-title":"measures a cross sectional examination","volume":"12","author":"Tangney","year":"2011","journal-title":"Vitamin cognition brain Neurology"},{"key":"ref1351","first-page":"132","article-title":"CD Cellular folate vitamer distribution during and after correction of vitamin deficiency a case for the methylfolate trap","author":"Smulders","year":"2006"},{"key":"ref901","first-page":"1999","article-title":"Biochemical indicators of B vitamin status in the US population after folic acid fortification : results from the National Health and Nutrition Examination Survey","author":"Pfeiffer","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"ref431","first-page":"37","article-title":"Efficacy of vitamins in lowering homocysteine in older men : maximal effects for those with deficiency and hyperhomocysteinemia","volume":"12","author":"Flicker","year":"2006","journal-title":"Stroke"},{"key":"ref1541","first-page":"250","article-title":"NS of vitamins status and homocysteine levels in elderly Taiwanese","volume":"14","author":"Chen","year":"2005","journal-title":"IL Shaw Association Asia Pac J Clin Nutr"},{"key":"ref551","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1093\/ajcn\/63.3.306","article-title":"rd Relations of vitamin folate homocysteine to cognitive performance in the Normative Study","volume":"12","author":"Riggs","year":"1996","journal-title":"vitamin Aging Am J Clin Nutr"},{"key":"ref741","first-page":"77","article-title":"Hyperhomocysteinemia - deficiency in elderly using Title IIIc nutrition services","volume":"20","author":"Johnson","year":"2003","journal-title":"vitamin Am J Clin Nutr"},{"key":"ref1211","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/1471-244X-13-145","article-title":"Association between vitamin levels and melancholic depressive symptoms a Finnish population - based study","volume":"12","author":"Seppala","year":"2013","journal-title":"b BMC Psychiatry"},{"key":"ref01","first-page":"77","article-title":"vitamins and homocysteine in Spanish institutionalized elderly","author":"Gonzalez","year":"2007","journal-title":"Int J Vitam Nutr Res"},{"key":"ref181","article-title":"Lindenbaum Prevalence of cobalamin deficiency in the Framingham elderly population","author":"Rosenberg","year":"1994","journal-title":"Am J Clin Nutr"},{"key":"ref1101","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1177\/15648265080292S129","article-title":"de Conclusions of a WHO Technical Consultation on folate and deficiencies","volume":"12","author":"Benoist","year":"2008","journal-title":"vitamin Food Nutr Bull"},{"key":"ref581","first-page":"85","article-title":"den de folate and the risk of anemia in old age : the Leiden Plus Study","volume":"12","author":"Elzen","year":"2008","journal-title":"Vitamin Arch Intern Med"},{"key":"ref641","article-title":"Low serum vitamin levels among psychiatric patients admitted in Butabika mental hospital in Uganda","volume":"12","author":"Ssonko","year":"2014","journal-title":"Res Notes"},{"key":"ref1251","article-title":"Reduction of plasma homocysteine and serum methylmalonate concentrations in apparently healthy elderly subjects after treatment with folic acid a randomised trial","volume":"12","author":"Lewerin","year":"2003","journal-title":"vitamin vitamin Eur J Clin Nutr"},{"key":"ref1431","article-title":"Low serum vitamin levels among psychiatric patients admitted in Butabika mental hospital in Uganda","volume":"12","author":"Ssonko","year":"2014","journal-title":"Res Notes"},{"key":"ref41","article-title":"Gonz\u00e1lez Algorithm for early diagnosis of vitamin in elderly people","volume":"12","author":"Palacios","year":"2013","journal-title":"Nutr Hosp"},{"key":"ref821","article-title":"Oral for patients suspected of subtle cobalamin deficiency : a multicentre pragmatic randomised controlled trial","volume":"12","author":"Favrat","year":"2011","journal-title":"vitamin BMC Fam Pract"},{"key":"ref1271","first-page":"132","article-title":"MS Elevated serum methylmalonic acid concentrations are common among elderly Americans","author":"Morris","year":"2002","journal-title":"J Nutr"},{"key":"ref1561","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1093\/ajcn\/70.5.911","article-title":"Racial differences in prevalence of cobalamin and folate deficiencies in disabled elderly women","author":"Stabler","year":"1999","journal-title":"Am J Clin Nutr"},{"key":"ref401","first-page":"30","article-title":"Prevalence of low serum folate and in an older Australian population","volume":"12","author":"Flood","year":"2006","journal-title":"vitamin J Public Health"},{"key":"ref841","doi-asserted-by":"crossref","DOI":"10.1515\/CCLM.2003.227","article-title":"Functional deficiency and determination of holotranscobalamin in populations at risk","author":"Herrmann","year":"2003","journal-title":"vitamin Clin Chem Lab Med"},{"key":"ref871","first-page":"457","article-title":"CH Vitamin dependent methionine metabolism and alcoholic liver disease","author":"Halsted","year":"2013","journal-title":"Clin Chem Lab Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/ageing\/afl150","article-title":"deficiency in the aged a population - based study","author":"Loikas","year":"2007","journal-title":"Vitamin Age Ageing"},{"key":"ref961","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.numecd.2011.10.001","article-title":"homocysteine status in an Italian blood donor population","volume":"12","author":"Zappacosta","year":"2013","journal-title":"vitamin Nutr Metab Cardiovasc Dis"},{"key":"ref151","first-page":"165","article-title":"de Oral cyanocobalamin supplementation in older people with vitamin deficiency a dose - finding trial","author":"Eussen","year":"2005","journal-title":"Arch Intern Med"},{"key":"ref751","first-page":"250","article-title":"NS of vitamins status and homocysteine levels in elderly Taiwanese","volume":"14","author":"Chen","year":"2005","journal-title":"IL Shaw Association Asia Pac J Clin Nutr"},{"key":"ref891","first-page":"1","article-title":"impact of folate deficiency","volume":"12","author":"Gonzalez","year":"2005","journal-title":"Health vitamin b Med"},{"key":"ref811","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/ageing\/afl150","article-title":"deficiency in the aged a population - based study","author":"Loikas","year":"2007","journal-title":"Vitamin Age Ageing"},{"key":"ref1461","first-page":"257","article-title":"Holotranscobalamin a first choice assay for diagnosing early vitamin deficiency","author":"Hvas","year":"2005","journal-title":"J Intern Med"},{"key":"ref911","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1373\/clinchem.2009.128678","article-title":"Determinants of plasma methylmalonic acid in a large population : implications for assessment of vitamin status","volume":"12","author":"Vogiatzoglou","year":"2009","journal-title":"Clin Chem"},{"key":"ref971","article-title":"Lindenbaum Prevalence of cobalamin deficiency in the Framingham elderly population","author":"Rosenberg","year":"1994","journal-title":"Am J Clin Nutr"},{"key":"ref1081","first-page":"124","article-title":"Effectiveness of the National Program of Complementary Feeding for older adults in Chile on vitamin status in older adults ; secondary outcome analysis from the CENEX Study","volume":"12","author":"Sanchez","year":"2013","journal-title":"Nutr J"},{"key":"ref1261","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1373\/clinchem.2005.061382","article-title":"of total vitamin holotranscobalamin singly and in combination in screening for metabolic vitamin deficiency","volume":"12","author":"Miller","year":"2006","journal-title":"Measurement Clin Chem"},{"key":"ref51","doi-asserted-by":"crossref","DOI":"10.1515\/CCLM.2003.227","article-title":"Functional deficiency and determination of holotranscobalamin in populations at risk","author":"Herrmann","year":"2003","journal-title":"vitamin Clin Chem Lab Med"},{"key":"ref541","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/ajcn\/74.2.233","article-title":"Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian","author":"Refsum","year":"2001","journal-title":"Am J Clin Nutr"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1046\/j.1532-5415.2002.50155.x","article-title":"Screening for cobalamin deficiency in geriatric outpatients : prevalence and influence of synthetic cobalamin intake","volume":"30","author":"Rajan","year":"2002","journal-title":"J Am Geriatr Soc"},{"key":"ref391","first-page":"231","article-title":"The limited value of methylmalonic acid homocysteine and holotranscobalamin in the diagnosis of early deficiency","volume":"12","author":"Goringe","year":"2006","journal-title":"Haematologica"},{"key":"ref1161","first-page":"249","article-title":"Serum cobalamin folate methylmalonic acid and total homocysteine as vitamin folate tissue deficiency markers amongst elderly Swedes a population - based study","volume":"12","author":"Bjorkegren","year":"2001","journal-title":"J Intern Med"},{"key":"ref201","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1515\/CCLM.2004.109","article-title":"Clinical utility of serum holotranscobalamin as a marker of cobalamin status in elderly patients with neuropsychiatric symptoms","volume":"42","author":"Nilsson","year":"2004","journal-title":"Clin Chem Lab Med"},{"key":"ref311","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1177\/15648265080292S129","article-title":"de Conclusions of a WHO Technical Consultation on folate and deficiencies","volume":"12","author":"Benoist","year":"2008","journal-title":"vitamin Food Nutr Bull"},{"key":"ref1481","first-page":"71","article-title":"Holotranscobalamin is an early marker of changes in cobalamin homeostasis randomized placebo - controlled study","author":"Nexo","year":"2002","journal-title":"Clin Chem"},{"key":"ref491","first-page":"85","article-title":"MS status in relation to anemia macrocytosis and cognitive impairment in older Americans in the age of folic acid fortification","volume":"12","author":"Morris","year":"2007","journal-title":"vitamin Am J Clin Nutr"},{"key":"ref601","first-page":"152","article-title":"The role of plasma melatonin and vitamins in the development of idiopathic tinnitus in the elderly","volume":"12","author":"Lasisi","year":"2012","journal-title":"Ghana Med"},{"key":"ref81","first-page":"457","article-title":"CH Vitamin dependent methionine metabolism and alcoholic liver disease","author":"Halsted","year":"2013","journal-title":"Clin Chem Lab Med"},{"key":"ref801","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/ajcn\/78.4.765","article-title":"vitamin status and concentrations of homocysteine and methylmalonic acid in elderly German women","author":"Wolters","year":"2003","journal-title":"Am J Clin Nutr"},{"key":"ref1291","first-page":"105","article-title":"Cobalamin - responsive disorders in the ambulatory care setting : unreliability of cobalamin methylmalonic acid and homocysteine testing","author":"Solomon","year":"2005","journal-title":"Blood"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1373\/clinchem.2009.128678","article-title":"Determinants of plasma methylmalonic acid in a large population : implications for assessment of vitamin status","volume":"12","author":"Vogiatzoglou","year":"2009","journal-title":"Clin Chem"},{"key":"ref1391","first-page":"152","article-title":"The role of plasma melatonin and vitamins in the development of idiopathic tinnitus in the elderly","volume":"12","author":"Lasisi","year":"2012","journal-title":"Ghana Med"},{"key":"ref421","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/1471-244X-13-145","article-title":"Association between vitamin levels and melancholic depressive symptoms a Finnish population - based study","volume":"12","author":"Seppala","year":"2013","journal-title":"b BMC Psychiatry"},{"key":"ref651","doi-asserted-by":"crossref","DOI":"10.1093\/ajcn\/82.6.1320","article-title":"Randomized controlled trial of homocysteine - lowering vitamin treatment in elderly patients with vascular disease","author":"Stott","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"ref1121","first-page":"133","article-title":"concentrations in an elderly latino population are predicted by serum gastrin concentrations and crystalline vitamin intake","volume":"12","author":"Campbell","year":"2003","journal-title":"Plasma vitamin J Nutr"},{"key":"ref611","first-page":"255","article-title":"UK deficiency neurological syndromes correlation of clinical cognitive evoked potential","author":"Kalita","year":"2008","journal-title":"Vitamin J Neurol"},{"key":"ref251","first-page":"204","article-title":"High prevalence of cobalamin deficiency in elderly outpatients","author":"Pennypacker","year":"1992","journal-title":"J Am Geriatr Soc"},{"key":"ref1441","doi-asserted-by":"crossref","DOI":"10.1093\/ajcn\/82.6.1320","article-title":"Randomized controlled trial of homocysteine - lowering vitamin treatment in elderly patients with vascular disease","author":"Stott","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"ref1371","first-page":"85","article-title":"den de folate and the risk of anemia in old age : the Leiden Plus Study","volume":"12","author":"Elzen","year":"2008","journal-title":"Vitamin Arch Intern Med"},{"key":"ref481","first-page":"132","article-title":"MS Elevated serum methylmalonic acid concentrations are common among elderly Americans","author":"Morris","year":"2002","journal-title":"J Nutr"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1373\/clinchem.2010.158154","article-title":"Diagnostic accuracy of holotranscobalamin methylmalonic acid serum cobalamin and other indicators of tissue vitamin status in the elderly","author":"Valente","year":"2011","journal-title":"AM Clin Chem"},{"key":"ref931","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1093\/ajcn\/58.4.468","article-title":"den Metabolic evidence that deficiencies of vitamin cobalamin folate occur commonly in elderly people","volume":"12","author":"Joosten","year":"1993","journal-title":"vitamin Am J Clin Nutr"},{"key":"ref591","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1093\/ajcn\/68.2.328","article-title":"van de van Role of cobalamin intake and atrophic gastritis in mild cobalamin deficiency in older Dutch subjects","author":"Asselt","year":"1998","journal-title":"Am J Clin Nutr"},{"key":"ref1061","doi-asserted-by":"crossref","DOI":"10.1093\/ajcn\/81.6.1372","article-title":"Factor cobalamin deficiencies and hyperhomocysteinemia in Bangladesh","author":"Gamble","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"ref31","article-title":"Oral for patients suspected of subtle cobalamin deficiency : a multicentre pragmatic randomised controlled trial","volume":"12","author":"Favrat","year":"2011","journal-title":"vitamin BMC Fam Pract"},{"key":"ref441","first-page":"123","article-title":"High prevalences of vitamin folic acid deficiency in elderly subjects in","volume":"12","author":"Figlin","year":"2003"},{"key":"ref511","first-page":"5","article-title":"Vitamin status and cognitive function in a long - term care population","author":"Paulionis","year":"2005"},{"key":"ref471","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1373\/clinchem.2005.061382","article-title":"of total vitamin holotranscobalamin singly and in combination in screening for metabolic vitamin deficiency","volume":"12","author":"Miller","year":"2006","journal-title":"Measurement Clin Chem"},{"key":"ref1411","first-page":"132","article-title":"de la The Chilean flour folic acid fortification program reduces serum homocysteine levels and masks vitamin deficiency in elderly people","author":"Hirsch","year":"2002","journal-title":"J Nutr"},{"key":"ref1491","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1136\/jnnp.74.7.959","article-title":"AD Low status in confirmed Alzheimer s disease as revealed by serum holotranscobalamin","volume":"12","author":"Refsum","year":"2003","journal-title":"vitamin J Neurol Psychiatry"},{"key":"ref281","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1093\/ageing\/afg109","article-title":"folate deficiency in later life","volume":"12","author":"Clarke","year":"2004","journal-title":"Vitamin Age Ageing"},{"key":"ref1221","first-page":"37","article-title":"Efficacy of vitamins in lowering homocysteine in older men : maximal effects for those with deficiency and hyperhomocysteinemia","volume":"12","author":"Flicker","year":"2006","journal-title":"Stroke"},{"key":"ref701","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1136\/jnnp.74.7.959","article-title":"AD Low status in confirmed Alzheimer s disease as revealed by serum holotranscobalamin","volume":"12","author":"Refsum","year":"2003","journal-title":"vitamin J Neurol Psychiatry"},{"key":"ref721","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1080\/07315724.1996.10718611","article-title":"Vitamin supplementation and other variables affecting serum homocysteine and methylmalonic acid concentrations in elderly men and women","volume":"15","author":"Koehler","year":"1996","journal-title":"J Am Coll Nutr"},{"key":"ref571","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3343\/kjlm.2010.30.2.185","article-title":"Relationship between the levels of holotranscobalamin and","volume":"12","author":"Woo","year":"2010","journal-title":"vitamin Korean J Lab Med"},{"key":"ref371","first-page":"249","article-title":"Serum cobalamin folate methylmalonic acid and total homocysteine as vitamin folate tissue deficiency markers amongst elderly Swedes a population - based study","volume":"12","author":"Bjorkegren","year":"2001","journal-title":"J Intern Med"},{"key":"ref411","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1046\/j.1365-2362.2000.00746.x","article-title":"Role of homocysteine cystathionine and methylmalonic acid measurement for diagnosis of vitamin deficiency in high - aged subjects","volume":"30","author":"Herrmann","year":"2000","journal-title":"Eur J Clin Invest"},{"key":"ref331","first-page":"133","article-title":"concentrations in an elderly latino population are predicted by serum gastrin concentrations and crystalline vitamin intake","volume":"12","author":"Campbell","year":"2003","journal-title":"Plasma vitamin J Nutr"},{"key":"ref1131","first-page":"82","article-title":"Efficacy of a day oral cyanocobalamin supplementation on vitamin B status in Spanish institutionalized elderly","volume":"28","author":"Albers","year":"2012","journal-title":"Int J Vitam Nutr Res"},{"key":"ref1001","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1373\/clinchem.2010.158154","article-title":"Diagnostic accuracy of holotranscobalamin methylmalonic acid serum cobalamin and other indicators of tissue vitamin status in the elderly","author":"Valente","year":"2011","journal-title":"AM Clin Chem"},{"key":"ref351","doi-asserted-by":"crossref","DOI":"10.1373\/clinchem.2003.021634","article-title":"Facts and recommendations about total homocysteine determinations : an expert opinion","volume":"50","author":"Refsum","year":"2004","journal-title":"Clin Chem"},{"key":"ref671","first-page":"257","article-title":"Holotranscobalamin a first choice assay for diagnosing early vitamin deficiency","author":"Hvas","year":"2005","journal-title":"J Intern Med"},{"key":"ref691","first-page":"71","article-title":"Holotranscobalamin is an early marker of changes in cobalamin homeostasis randomized placebo - controlled study","author":"Nexo","year":"2002","journal-title":"Clin Chem"},{"key":"ref71","first-page":"560","article-title":"Psychiatric manifestations of vitamin deficiency a case report","volume":"29","author":"Durand","year":"2003","journal-title":"Encephale"},{"key":"ref731","first-page":"772","article-title":"cobalamin and folate status and their relations to neurocognitive and psychological markers in elderly in Northeasten of Iran Iran Basic","volume":"16","author":"Manavifar","year":"2013","journal-title":"Med Sci"},{"key":"ref831","article-title":"Gonz\u00e1lez Algorithm for early diagnosis of vitamin in elderly people","volume":"12","author":"Palacios","year":"2013","journal-title":"Nutr Hosp"},{"key":"ref361","first-page":"346","article-title":"Effects of vitamin folate supplements in elderly people with normal serum vitamin concentrations","volume":"12","author":"Naurath","year":"1995","journal-title":"vitamin Lancet"},{"key":"ref771","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1093\/ajcn\/70.5.911","article-title":"Racial differences in prevalence of cobalamin and folate deficiencies in disabled elderly women","author":"Stabler","year":"1999","journal-title":"Am J Clin Nutr"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/ajcn\/78.4.765","article-title":"vitamin status and concentrations of homocysteine and methylmalonic acid in elderly German women","author":"Wolters","year":"2003","journal-title":"Am J Clin Nutr"},{"key":"ref661","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1373\/clinchem.2003.021717","article-title":"status in the elderly as judged by available biochemical markers","volume":"12","author":"Obeid","year":"2004","journal-title":"Vitamin Clin Chem"}],"container-title":["Clinical Chemistry and Laboratory Medicine (CCLM)"],"original-title":[],"link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/cclm-2014-0784\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T23:46:32Z","timestamp":1619048792000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/cclm-2014-0784\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,1]]},"references-count":144,"journal-issue":{"issue":"8"},"URL":"https:\/\/doi.org\/10.1515\/cclm-2014-0784","relation":{},"ISSN":["1437-4331","1434-6621"],"issn-type":[{"value":"1437-4331","type":"electronic"},{"value":"1434-6621","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1,1]]}}}