{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:08:42Z","timestamp":1787022522993,"version":"build-2736575974"},"reference-count":92,"publisher":"Walter de Gruyter GmbH","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A large body of evidence suggests that not only cerebral but also systemic oxidative stress (OxS) might be involved in the pathogenesis of late onset Alzheimer\u2019s disease (LOAD) and vascular dementia (VAD), as well as of the prodromal phase of dementia, the so-called mild cognitive impairment (MCI). In the present study, we evaluated whether paraoxonase 1 (PON-1) and ferroxidase (FeOx) activities, because of their well acknowledged effectiveness as systemic antioxidants, might be associated with dementia and\/or MCI.<\/jats:p>\n                  <jats:p>Serum arylesterase and paraoxonase of PON-1, along with FeOx I (ceruloplasmin-related) and II activities were assessed in 223 MCI, 162 LOAD, 65 VAD patients, and in 143 older normal cognitive controls.<\/jats:p>\n                  <jats:p>Among the enzymatic activities examined, only arylesterase significantly changed across the groups (ANOVA: p&lt;0.001), with similar lower levels in MCI, LOAD, and VAD compared to controls. By multivariate logistic regression analysis we showed that, in respect to controls, low levels (under the median value) of serum arylesterase were independently associated with an increase in the likelihood of being affected by LOAD [odds ratio (OR) 2.8, 95% confidence interval (CI) 1.5\u20135.0], VAD (OR 2.7, 95% CI 1.2\u20136.2), or MCI (OR 2.3, 95% CI 1.3\u20133.8).<\/jats:p>\n                  <jats:p>Overall, our results suggest that depression of PON-1, and in particular, of arylesterase activity, in serum might be an early feature of dementia-related diseases. Further longitudinal exploration of the role of this enzyme in the onset and progression of these disorders are required.<\/jats:p>","DOI":"10.1515\/cclm-2014-0803","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T05:00:36Z","timestamp":1418101236000},"source":"Crossref","is-referenced-by-count":30,"title":["PON-1 and ferroxidase activities in older patients with mild cognitive impairment, late onset Alzheimer\u2019s disease or vascular dementia"],"prefix":"10.1515","volume":"53","author":[{"given":"Carlo","family":"Cervellati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Romani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo M.","family":"Bergamini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Bosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juana Maria","family":"Sanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelina","family":"Passaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Zuliani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref631","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1001\/archpsyc.57.1.47","article-title":"In vivo evaluation of brain iron in Alzheimer disease using magnetic resonance imaging","volume":"57","author":"Bartzokis","year":"2000","journal-title":"Arch Gen Psychiatry"},{"key":"ref991","first-page":"1","article-title":"Camps Serum paraoxonase activity and genetic polymorphisms : common errors in measurement and interpretation of results","author":"Mackness","year":"2010","journal-title":"Clin Chem Lab Med"},{"key":"ref561","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3233\/JAD-2010-1239","article-title":"Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment","volume":"19","author":"Smith","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"ref701","first-page":"1","article-title":"DE Oxidative inactivation of paraoxonase an antioxidant protein and its effect on antioxidant action Free","volume":"30","author":"Nguyen","year":"2003","journal-title":"Res"},{"key":"ref281","first-page":"1","article-title":"activity a new vascular marker of dementia","author":"Dantoine","year":"2002","journal-title":"Ann NY Acad Sci"},{"key":"ref681","first-page":"309507","article-title":"Systemic oxidative stress and conversion to dementia of elderly patients with mild cognitive impairment Bio","author":"Cervellati","year":"2014","journal-title":"Med Res Int"},{"key":"ref511","first-page":"338","article-title":"Acidic pH enables caeruloplasmin to catalyse the modification of low - density lipoprotein","author":"Lamb","year":"1994","journal-title":"FEBS Lett"},{"key":"ref891","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/ana.20629","article-title":"Lipid peroxidation is an early event in the brain in amnestic mild cognitive impairment","author":"Marksbery","year":"2005","journal-title":"Ann Neurol"},{"key":"ref651","article-title":"of tau protein as the link between oxidative stress mitochondrial dysfunction and connectivity failure : implications for Alzheimer s disease Oxid","author":"Mondrag\u00f3n","year":"2013","journal-title":"Med Cell"},{"key":"ref911","first-page":"24","article-title":"How do nutritional antioxidants really work tone and para - hormesis versus free radical scavenging in vivo Free","volume":"66","author":"Forman","year":"2014","journal-title":"Biol Med"},{"key":"ref351","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1373\/clinchem.2005.061408","article-title":"of oxidative damage in human disease","volume":"23","author":"Dalle","year":"2006","journal-title":"Biomarkers Clin Chem"},{"key":"ref551","doi-asserted-by":"crossref","first-page":"584","DOI":"10.2174\/138161210790883868","article-title":"Low grade inflammation as a common pathogenetic denominator in age - related diseases : novel drug targets for anti - ageing strategies and successful ageing achievement Des","volume":"16","author":"Candore","year":"2010","journal-title":"Curr Pharm"},{"key":"ref381","first-page":"24","article-title":"How do nutritional antioxidants really work tone and para - hormesis versus free radical scavenging in vivo Free","volume":"66","author":"Forman","year":"2014","journal-title":"Biol Med"},{"key":"ref451","first-page":"1015","article-title":"Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease","author":"Erlich","year":"2012","journal-title":"Neurobiol Aging"},{"key":"ref111","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2011.08.005","article-title":"PH amyloid beta - induced oxidative DNA damage and mitochondrial dysfunction in Alzheimer s disease : implications for early intervention and therapeutics","author":"Mao","year":"2011","journal-title":"Aging Biochim Biophys Acta"},{"key":"ref491","first-page":"33","article-title":"enhances DNA damage induced by hydrogen peroxide in vitro Free","author":"Kim","year":"2000","journal-title":"Res"},{"key":"ref971","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2007.05.021","article-title":"Association study of the paraoxonase gene with the risk of developing Alzheimer s disease","volume":"30","author":"Chapuis","year":"2009","journal-title":"Neurobiol Aging"},{"key":"ref931","first-page":"498","article-title":"The relationship between oxidative stress markers and visual evoked potentials in different hypertension models","volume":"14","author":"G\u00f6\u00e7men","year":"2014"},{"key":"ref471","first-page":"49","article-title":"The effect of apolipoprotein genotype on biomarkers of amyloidogenesis tau pathology and neurodegeneration in Alzheimer s disease","author":"Leoni","year":"2011","journal-title":"Clin Chem Lab Med"},{"key":"ref771","first-page":"287","article-title":"Rethinking the role of ceruloplasmin in brain iron metabolism","author":"Qian","year":"2011","journal-title":"Brain Res Rev"},{"key":"ref921","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.clinbiochem.2008.02.010","article-title":"and arylesterase activities in untreated dipper and non - dipper hypertensive patients","author":"Yildiz","year":"2008","journal-title":"Clin Biochem"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"584","DOI":"10.2174\/138161210790883868","article-title":"Low grade inflammation as a common pathogenetic denominator in age - related diseases : novel drug targets for anti - ageing strategies and successful ageing achievement Des","volume":"16","author":"Candore","year":"2010","journal-title":"Curr Pharm"},{"key":"ref961","first-page":"1","article-title":"Pi Lack of an association between Paraoxonase gene polymorphisms Alzheimer s disease a meta - analysis","author":"Zhang","year":"2012","journal-title":"Neurosci Lett"},{"key":"ref421","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.mcna.2009.02.015","article-title":"Oxidative stress hypertension","author":"Harrison","year":"2009","journal-title":"Med Clin Am"},{"key":"ref301","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"EM Clinical diagnosis of Alzheimer s disease : report of the NINCDS - ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer s Disease","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"ref761","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1093\/clinchem\/44.11.2313","article-title":"Automated measurement of serum ferroxidase activity","author":"Erel","year":"1998","journal-title":"Clin Chem"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1001\/archpsyc.57.1.47","article-title":"In vivo evaluation of brain iron in Alzheimer disease using magnetic resonance imaging","volume":"57","author":"Bartzokis","year":"2000","journal-title":"Arch Gen Psychiatry"},{"key":"ref241","first-page":"287","article-title":"Rethinking the role of ceruloplasmin in brain iron metabolism","author":"Qian","year":"2011","journal-title":"Brain Res Rev"},{"key":"ref751","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.2174\/138161211798072463","article-title":"Importance of iron chelation in free radical - induced oxidative stress and human disease Des","volume":"17","author":"Jomova","year":"2011","journal-title":"Curr Pharm"},{"key":"ref251","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1159\/000017067","article-title":"Copper ceruloplasmin and superoxide dismutase in patients with Alzheimer s disease","author":"Snaedal","year":"1998","journal-title":"Dement Geriatr Cogn Dis"},{"key":"ref541","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.jpsychires.2006.02.008","article-title":"Plasma cytochines profile in older subject with late onset Alzheimer s disease or vascular dementia","author":"Zuliani","year":"2007","journal-title":"J Psychiatr Res"},{"key":"ref81","first-page":"49","article-title":"Oxidative stress inflammation cancer how are they linked Free","volume":"16","author":"Reuter","year":"2010","journal-title":"Biol Med"},{"key":"ref741","first-page":"432","article-title":"Novel serum paraoxonase activity assays are associated with coronary artery disease","author":"Martinelli","year":"2009","journal-title":"Clin Chem Lab Med"},{"key":"ref951","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.mcna.2009.02.015","article-title":"Oxidative stress hypertension","author":"Harrison","year":"2009","journal-title":"Med Clin Am"},{"key":"ref371","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/ana.10272","article-title":"Peripheral isoprostanes and neuroprostanes are not increased in Alzheimer s disease","author":"Montine","year":"2002","journal-title":"Ann Neurol"},{"key":"ref1001","first-page":"49","article-title":"The effect of apolipoprotein genotype on biomarkers of amyloidogenesis tau pathology and neurodegeneration in Alzheimer s disease","author":"Leoni","year":"2011","journal-title":"Clin Chem Lab Med"},{"key":"ref711","first-page":"1","article-title":"Association of oxidative stress with HDL particle size in middle - aged subjects","volume":"22","author":"Vekic","year":"2007","journal-title":"Eur J Clin Invest"},{"key":"ref1021","first-page":"33","article-title":"enhances DNA damage induced by hydrogen peroxide in vitro Free","author":"Kim","year":"2000","journal-title":"Res"},{"key":"ref151","first-page":"309507","article-title":"Systemic oxidative stress and conversion to dementia of elderly patients with mild cognitive impairment Bio","author":"Cervellati","year":"2014","journal-title":"Med Res Int"},{"key":"ref181","first-page":"1","article-title":"Association of oxidative stress with HDL particle size in middle - aged subjects","volume":"22","author":"Vekic","year":"2007","journal-title":"Eur J Clin Invest"},{"key":"ref221","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.2174\/138161211798072463","article-title":"Importance of iron chelation in free radical - induced oxidative stress and human disease Des","volume":"17","author":"Jomova","year":"2011","journal-title":"Curr Pharm"},{"key":"ref791","first-page":"490","article-title":"Copper and ceruloplasmin abnormalities in Alzheimer s disease Alzheimers","volume":"25","author":"Brewer","year":"2010","journal-title":"Am"},{"key":"ref581","first-page":"184","article-title":"la Is Alzheimer s disease a neurodegenerative or a vascular disorder Data dogma dialectics","author":"De","year":"2004","journal-title":"Lancet Neurol"},{"key":"ref591","first-page":"257","article-title":"oxidative stress in Alzheimer disease","author":"Zhu","year":"2007","journal-title":"Vascular J Neurol Sci"},{"key":"ref391","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.clinbiochem.2008.02.010","article-title":"and arylesterase activities in untreated dipper and non - dipper hypertensive patients","author":"Yildiz","year":"2008","journal-title":"Clin Biochem"},{"key":"ref901","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/ana.10272","article-title":"Peripheral isoprostanes and neuroprostanes are not increased in Alzheimer s disease","author":"Montine","year":"2002","journal-title":"Ann Neurol"},{"key":"ref201","first-page":"1","article-title":"activity but not phenotype is a predictor of coronary artery disease in a middle - aged Serbian population","volume":"13","author":"Kotur","year":"2006","journal-title":"Clin Chem Lab Med"},{"key":"ref851","article-title":"Current concepts in mild cognitive impairment","author":"Petersen","year":"2001","journal-title":"Arch"},{"key":"ref441","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2007.05.021","article-title":"Association study of the paraoxonase gene with the risk of developing Alzheimer s disease","volume":"30","author":"Chapuis","year":"2009","journal-title":"Neurobiol Aging"},{"key":"ref801","first-page":"1","article-title":"and iron proteins in the serum of patients with Alzheimer s disease Extra","author":"Torsdottir","year":"2011","journal-title":"Dement Geriatr Cogn Dis"},{"key":"ref261","first-page":"490","article-title":"Copper and ceruloplasmin abnormalities in Alzheimer s disease Alzheimers","volume":"25","author":"Brewer","year":"2010","journal-title":"Am"},{"key":"ref321","article-title":"Current concepts in mild cognitive impairment","author":"Petersen","year":"2001","journal-title":"Arch"},{"key":"ref271","first-page":"1","article-title":"and iron proteins in the serum of patients with Alzheimer s disease Extra","author":"Torsdottir","year":"2011","journal-title":"Dement Geriatr Cogn Dis"},{"key":"ref361","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/ana.20629","article-title":"Lipid peroxidation is an early event in the brain in amnestic mild cognitive impairment","author":"Marksbery","year":"2005","journal-title":"Ann Neurol"},{"key":"ref461","first-page":"1","article-title":"Camps Serum paraoxonase activity and genetic polymorphisms : common errors in measurement and interpretation of results","author":"Mackness","year":"2010","journal-title":"Clin Chem Lab Med"},{"key":"ref671","first-page":"337","article-title":"Oxidative balance homocysteine and uric acid levels in older patients with late onset Alzheimer s disease or vascular dementia","author":"Cervellati","year":"2014","journal-title":"J Neurol Sci"},{"key":"ref51","first-page":"184","article-title":"la Is Alzheimer s disease a neurodegenerative or a vascular disorder Data dogma dialectics","author":"De","year":"2004","journal-title":"Lancet Neurol"},{"key":"ref231","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1093\/clinchem\/44.11.2313","article-title":"Automated measurement of serum ferroxidase activity","author":"Erel","year":"1998","journal-title":"Clin Chem"},{"key":"ref841","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1212\/WNL.43.2.250","article-title":"dementia diagnostic criteria for research studies Report of the NINDS International Workshop","author":"Rom\u00e1n","year":"1993","journal-title":"Vascular Neurology"},{"key":"ref211","first-page":"432","article-title":"Novel serum paraoxonase activity assays are associated with coronary artery disease","author":"Martinelli","year":"2009","journal-title":"Clin Chem Lab Med"},{"key":"ref811","first-page":"1","article-title":"activity a new vascular marker of dementia","author":"Dantoine","year":"2002","journal-title":"Ann NY Acad Sci"},{"key":"ref171","first-page":"1","article-title":"DE Oxidative inactivation of paraoxonase an antioxidant protein and its effect on antioxidant action Free","volume":"30","author":"Nguyen","year":"2003","journal-title":"Res"},{"key":"ref611","first-page":"49","article-title":"Oxidative stress inflammation cancer how are they linked Free","volume":"16","author":"Reuter","year":"2010","journal-title":"Biol Med"},{"key":"ref431","first-page":"1","article-title":"Pi Lack of an association between Paraoxonase gene polymorphisms Alzheimer s disease a meta - analysis","author":"Zhang","year":"2012","journal-title":"Neurosci Lett"},{"key":"ref721","first-page":"1","article-title":"Relationship of paraoxonase gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk","author":"Zhang","year":"2008","journal-title":"Am Med Assoc"},{"key":"ref121","article-title":"of tau protein as the link between oxidative stress mitochondrial dysfunction and connectivity failure : implications for Alzheimer s disease Oxid","author":"Mondrag\u00f3n","year":"2013","journal-title":"Med Cell"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.jpsychires.2006.02.008","article-title":"Plasma cytochines profile in older subject with late onset Alzheimer s disease or vascular dementia","author":"Zuliani","year":"2007","journal-title":"J Psychiatr Res"},{"key":"ref601","first-page":"303","article-title":"induces cell damage via oxidative stress in retinal epithelial cells Free","volume":"12","author":"Cervellati","year":"2014","journal-title":"Hypoxia Res"},{"key":"ref1051","first-page":"1","article-title":"Role of paraoxonase in organophosphate metabolism implications in neurodegenerative diseases","volume":"24","author":"Androutsopoulos","year":"2011","journal-title":"AM Appl Pharmacol"},{"key":"ref141","first-page":"337","article-title":"Oxidative balance homocysteine and uric acid levels in older patients with late onset Alzheimer s disease or vascular dementia","author":"Cervellati","year":"2014","journal-title":"J Neurol Sci"},{"key":"ref731","first-page":"1","article-title":"activity but not phenotype is a predictor of coronary artery disease in a middle - aged Serbian population","volume":"13","author":"Kotur","year":"2006","journal-title":"Clin Chem Lab Med"},{"key":"ref191","first-page":"1","article-title":"Relationship of paraoxonase gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk","author":"Zhang","year":"2008","journal-title":"Am Med Assoc"},{"key":"ref861","first-page":"2338","article-title":"Du The polymorphic paraoxonase arylesterase isozymes of human serum Fed","author":"La","year":"1984","journal-title":"Proc"},{"key":"ref831","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"EM Clinical diagnosis of Alzheimer s disease : report of the NINCDS - ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer s Disease","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"ref981","first-page":"1015","article-title":"Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease","author":"Erlich","year":"2012","journal-title":"Neurobiol Aging"},{"key":"ref311","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1212\/WNL.43.2.250","article-title":"dementia diagnostic criteria for research studies Report of the NINDS International Workshop","author":"Rom\u00e1n","year":"1993","journal-title":"Vascular Neurology"},{"key":"ref61","first-page":"257","article-title":"oxidative stress in Alzheimer disease","author":"Zhu","year":"2007","journal-title":"Vascular J Neurol Sci"},{"key":"ref481","first-page":"1","article-title":"gene polymorphisms and arylesterase activity of the enzyme in patients with dementia","author":"Bednarska","year":"2013","journal-title":"Folia Neuropathol"},{"key":"ref1041","first-page":"338","article-title":"Acidic pH enables caeruloplasmin to catalyse the modification of low - density lipoprotein","author":"Lamb","year":"1994","journal-title":"FEBS Lett"},{"key":"ref1011","first-page":"1","article-title":"gene polymorphisms and arylesterase activity of the enzyme in patients with dementia","author":"Bednarska","year":"2013","journal-title":"Folia Neuropathol"},{"key":"ref1031","first-page":"501","article-title":"Intact human ceruloplasmin oxidatively modifies low density lipoprotein","author":"Ehrenwald","year":"1994","journal-title":"J Clin Invest"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3233\/JAD-2010-1239","article-title":"Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment","volume":"19","author":"Smith","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"ref501","first-page":"501","article-title":"Intact human ceruloplasmin oxidatively modifies low density lipoprotein","author":"Ehrenwald","year":"1994","journal-title":"J Clin Invest"},{"key":"ref401","first-page":"498","article-title":"The relationship between oxidative stress markers and visual evoked potentials in different hypertension models","volume":"14","author":"G\u00f6\u00e7men","year":"2014"},{"key":"ref781","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1159\/000017067","article-title":"Copper ceruloplasmin and superoxide dismutase in patients with Alzheimer s disease","author":"Snaedal","year":"1998","journal-title":"Dement Geriatr Cogn Dis"},{"key":"ref71","first-page":"303","article-title":"induces cell damage via oxidative stress in retinal epithelial cells Free","volume":"12","author":"Cervellati","year":"2014","journal-title":"Hypoxia Res"},{"key":"ref41","first-page":"37","article-title":"Oxidized low density lipoprotein : atherogenic and proinflammatory characteristics during macrophage foam cell formation An inhibitory role for nutritional antioxidants and serum paraoxonase","author":"Kaplan","year":"1999","journal-title":"Clin Chem Lab Med"},{"key":"ref331","first-page":"2338","article-title":"Du The polymorphic paraoxonase arylesterase isozymes of human serum Fed","author":"La","year":"1984","journal-title":"Proc"},{"key":"ref881","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1373\/clinchem.2005.061408","article-title":"of oxidative damage in human disease","volume":"23","author":"Dalle","year":"2006","journal-title":"Biomarkers Clin Chem"},{"key":"ref521","first-page":"1","article-title":"Role of paraoxonase in organophosphate metabolism implications in neurodegenerative diseases","volume":"24","author":"Androutsopoulos","year":"2011","journal-title":"AM Appl Pharmacol"},{"key":"ref571","first-page":"37","article-title":"Oxidized low density lipoprotein : atherogenic and proinflammatory characteristics during macrophage foam cell formation An inhibitory role for nutritional antioxidants and serum paraoxonase","author":"Kaplan","year":"1999","journal-title":"Clin Chem Lab Med"},{"key":"ref641","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2011.08.005","article-title":"PH amyloid beta - induced oxidative DNA damage and mitochondrial dysfunction in Alzheimer s disease : implications for early intervention and therapeutics","author":"Mao","year":"2011","journal-title":"Aging Biochim Biophys Acta"}],"container-title":["Clinical Chemistry and Laboratory Medicine (CCLM)"],"original-title":[],"link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/cclm-2014-0803\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T19:46:36Z","timestamp":1619034396000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/cclm-2014-0803\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,1]]},"references-count":92,"journal-issue":{"issue":"7"},"URL":"https:\/\/doi.org\/10.1515\/cclm-2014-0803","relation":{},"ISSN":["1437-4331","1434-6621"],"issn-type":[{"value":"1437-4331","type":"electronic"},{"value":"1434-6621","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1,1]]}}}