{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T08:33:51Z","timestamp":1778747631652,"version":"3.51.4"},"reference-count":124,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In recent years, an increasing amount of literature is emerging on candidate urine and blood-based biomarkers associated with incidence and severity of preeclampsia (PE) in pregnant women. While enthusiasm on the usefulness of several of these markers in predicting PE is evolving, essentially all work so far has focused on the needs of high-resource settings and high-income countries, resulting primarily in multi-parameter laboratory assays based on proteomic and metabolomics analysis techniques. These highly complex methods, however, require laboratory capabilities that are rarely available or affordable in low-resource settings (LRS). The importance of quantifying maternal and perinatal risks and identifying which pregnancies can be safely prolonged is also much greater in LRS, where intensive care facilities that can rapidly respond to PE-related health threats for women and infants are limited. For these reasons, simple, low cost, sensitive, and specific point-of-care (POC) tests are needed that can be performed by antenatal health care providers in LRS and that can facilitate decisions about detection and management of PE. Our study aims to provide a comprehensive systematic review of current and emerging blood and urine biomarkers for PE, not only on the basis of their clinical performance, but also of their suitability to be used in LRS-compatible test formats, such as lateral flow and other variants of POC rapid assays.<\/jats:p>","DOI":"10.1515\/cclm-2015-0069","type":"journal-article","created":{"date-parts":[[2015,5,20]],"date-time":"2015-05-20T17:06:27Z","timestamp":1432141587000},"source":"Crossref","is-referenced-by-count":19,"title":["Towards biomarker-based tests that can facilitate decisions about prevention and management of preeclampsia in low-resource settings"],"prefix":"10.1515","volume":"54","author":[{"given":"Nathalie","family":"Acestor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Goett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara M.","family":"Herrick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susheela M.","family":"Engelbrecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia M.","family":"Harner-Jay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonnie J.","family":"Howell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard H.","family":"Weigl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref481","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1600-0412.2011.01238.x","article-title":"Impaired endothelial function and elevated levels of pentraxin in early - 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of - care biomarker for assessment of preeclampsia","author":"Rasanen","journal-title":"Am J Obstet Gynecol"},{"key":"ref371","first-page":"13288","article-title":"Tal Abnormalities in oxygen sensing define early and late onset preeclampsia as distinct pathologies One","author":"Rolfo","year":"2010"},{"key":"ref1011","first-page":"125","article-title":"Serum concentrations of CA in normal and preeclamptic pregnancies","volume":"12","author":"Ozat","year":"2011","journal-title":"Arch Gynecol Obstet"},{"key":"ref231","first-page":"1","article-title":"WHO managing complications in pregnancy and childbirth : a guide for midwives and doctors Available from http whqlibdoc who int publications pdf ua Accessed on","volume":"16","author":"December","year":"2007","journal-title":"World Health Organization eng"},{"key":"ref581","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1161\/HYPERTENSIONAHA.114.03848","article-title":"NA Vasopressin in preeclampsia : a novel very early human pregnancy biomarker and clinically relevant mouse model","author":"Santillan","year":"2014","journal-title":"Hypertension"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"8","DOI":"10.5468\/OGS.2013.56.1.8","article-title":"Random urine protein \/ creatinine ratio readily predicts proteinuria in preeclampsia","volume":"56","author":"Park","year":"2013","journal-title":"Obstet Gynecol Sci"},{"key":"ref1021","doi-asserted-by":"crossref","DOI":"10.1161\/HYPERTENSIONAHA.113.01420","article-title":"Urinary excretion of in severe preeclampsia : tipping the balance of complement activation in pregnancy","author":"Burwick","year":"2013","journal-title":"Hypertension"},{"key":"ref771","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1080\/10641950701521742","article-title":"Current NHBPEP criteria for severe preeclampsia do not uniformly predict adverse maternal or perinatal outcomes","volume":"26","author":"Menzies","year":"2007","journal-title":"Hypertens Pregnancy"},{"key":"ref1071","first-page":"13288","article-title":"Tal Abnormalities in oxygen sensing define early and late onset preeclampsia as distinct pathologies One","author":"Rolfo","year":"2010"},{"key":"ref1081","first-page":"1","article-title":"\u03b2 dehydrogenase is dysregulated by miR and miR c that are aberrantly expressed in preeclamptic placentas : a novel marker for predicting preeclampsia","volume":"17","author":"Ishibashi","year":"2012","journal-title":"Hypertension"},{"key":"ref621","first-page":"2015","article-title":"Could molecular assessment of calcium metabolism be a useful tool to early screen patients at risk for pre - 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eclampsia","author":"Sibai","year":"2009","journal-title":"Am J Obstet Gynecol"},{"key":"ref501","first-page":"119","article-title":"Plasma uric acid remains a marker of poor outcome in hypertensive pregnancy : a retrospective cohort study","author":"Hawkins","year":"2012","journal-title":"J Obstet Gynaecol"},{"key":"ref1091","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3109\/10641950903242667","article-title":"Urinary inositol phosphoglycan type as a marker for prediction of preeclampsia and novel implications for the pathophysiology of this disorder","volume":"29","author":"Paine","year":"2010","journal-title":"Hypertens Pregnancy"},{"key":"ref261","first-page":"1","article-title":"Diagnostic utility of soluble fms - like tyrosine kinase and soluble endoglin in hypertensive diseases of pregnancy","volume":"28","author":"Salahuddin","year":"2007","journal-title":"Am J Obstet Gynecol"},{"key":"ref711","first-page":"367","article-title":"WHO analysis of causes of maternal death : a systematic","author":"Khan","year":"2006","journal-title":"review Lancet"},{"key":"ref721","article-title":"risk prediction model for the assessment and triage of women with hypertensive disorders of pregnancy in low - resourced settings : the miniPIERS ( Pre - eclampsia Integrated Estimate of RiSk ) multi - country prospective cohort study","volume":"11","author":"Payne","year":"2014","journal-title":"PLoS Med"},{"key":"ref1261","first-page":"2015","article-title":"Maternal serum glycosylated fibronectin as a point - of - care biomarker for assessment of preeclampsia","author":"Rasanen","journal-title":"Am J Obstet Gynecol"},{"key":"ref681","first-page":"226","article-title":"multi - centre phase IIa clinical study of predictive testing for preeclampsia : improved pregnancy outcomes via early detection IMPROvED Pregnancy Childbirth","volume":"13","author":"Navaratnam","year":"2013"},{"key":"ref381","first-page":"1","article-title":"\u03b2 dehydrogenase is dysregulated by miR and miR c that are aberrantly expressed in preeclamptic placentas : a novel marker for predicting preeclampsia","volume":"17","author":"Ishibashi","year":"2012","journal-title":"Hypertension"},{"key":"ref1281","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1161\/HYPERTENSIONAHA.114.03848","article-title":"NA Vasopressin in preeclampsia : a novel very early human pregnancy biomarker and clinically relevant mouse model","author":"Santillan","year":"2014","journal-title":"Hypertension"},{"key":"ref601","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1161\/HYPERTENSIONAHA.113.02688","article-title":"Elevation of urinary adipsin in preeclampsia : correlation with urine protein concentration and the potential use for a rapid diagnostic test","author":"Wang","year":"2014","journal-title":"Hypertension"},{"key":"ref1331","doi-asserted-by":"crossref","DOI":"10.1093\/clinchem\/32.8.1437","article-title":"Measurement of ionized calcium in serum with ion - selective electrodes mature technology that can meet the daily service needs","author":"Bowers","year":"1986","journal-title":"Clin Chem"},{"key":"ref541","first-page":"87","article-title":"Second trimester neutrophil gelatinase - associated lipocalin as a potential prediagnostic marker of preeclampsia","author":"Anna","year":"2008","journal-title":"Acta Obstet Gynecol Scand"},{"key":"ref731","first-page":"2015","article-title":"FA Risk factors and effective management of preeclampsia Control","volume":"8","author":"Kenny","journal-title":"English Blood"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1080\/13547500903033415","article-title":"Serum markers in pre - eclampsia","volume":"14","author":"Kharb","year":"2009","journal-title":"Biomarkers"}],"container-title":["Clinical Chemistry and Laboratory Medicine (CCLM)"],"original-title":[],"link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/cclm-2015-0069\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T23:48:45Z","timestamp":1619048925000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/cclm-2015-0069\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,1]]},"references-count":124,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1515\/cclm-2015-0069","relation":{},"ISSN":["1437-4331","1434-6621"],"issn-type":[{"value":"1437-4331","type":"electronic"},{"value":"1434-6621","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1,1]]}}}