{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:31:33Z","timestamp":1787243493525,"version":"build-2736575974"},"reference-count":34,"publisher":"Walter de Gruyter GmbH","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Urokinase plasminogen activator receptor (uPAR) is a key component of the fibrinolytic system involved in extracellular matrix remodeling and angiogenesis. Novel animal models supported the key role of uPAR not only in fibrosis but also in systemic sclerosis (SSc)-related microvascular abnormalities. The aim of this study was to investigate plasma soluble uPAR (suPAR) levels in SSc, and their association with organ-specific involvement.<\/jats:p>\n                  <jats:p>suPAR concentrations were measured by ELISA in SSc patient (n=83) and in healthy controls (n=29). Simultaneously, CRP and ESR were assessed. Detailed clinical data including skin, lung, heart and microvascular characteristics were evaluated at sampling.<\/jats:p>\n                  <jats:p>suPAR values were higher in SSc patients than in controls. Subgroup analysis showed higher suPAR values in diffuse cutaneous- than in limited cutaneous SSc and correlated with anti-Scl-70+. suPAR levels also associated with pulmonary function test parameters of fibrosis, presence of microvascular lesions (e.g., Raynaud phenomenon, naifold capillaroscopic abnormalities and digital ulcers) and arthritis.<\/jats:p>\n                  <jats:p>Our data indicate that suPAR might be a valuable early diagnostic marker of SSc which also correlates with disease severity.<\/jats:p>","DOI":"10.1515\/cclm-2015-0079","type":"journal-article","created":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T04:21:09Z","timestamp":1429503669000},"source":"Crossref","is-referenced-by-count":18,"title":["Increased plasma soluble urokinase plasminogen activator receptor levels in systemic sclerosis: possible association with microvascular abnormalities and extent of fibrosis"],"prefix":"10.1515","volume":"53","author":[{"given":"N\u00f3ra","family":"Leg\u00e1ny","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gergely","family":"Toldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg H.W.","family":"Distler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Beyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bal\u00e1zs","family":"Szalay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Kov\u00e1cs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barna","family":"V\u00e1s\u00e1rhelyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"Balog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref211","article-title":"Increased serum levels and tissue expression of matrix metalloproteinase in patients with systemic sclerosis : correlation with severity of skin and pulmonary fibrosis and vascular damage","volume":"12","author":"Manetti","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"ref331","first-page":"233","article-title":"Soluble urokinase plasminogen activator receptor measurements : infuence of sample handling Markers","volume":"16","author":"Riisbro","year":"2001","journal-title":"Int J Biol"},{"key":"ref271","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1515\/cclm-2012-0221","article-title":"Soluble urokinase plasminogen activator receptor suPAR in the assessment of inflammatory activity of rheumatoid arthritis patients in remission","author":"Toldi","year":"2013","journal-title":"Clin Chem Lab Med"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1515\/cclm-2012-0221","article-title":"Soluble urokinase plasminogen activator receptor suPAR in the assessment of inflammatory activity of rheumatoid arthritis patients in remission","author":"Toldi","year":"2013","journal-title":"Clin Chem Lab Med"},{"key":"ref251","first-page":"128","article-title":"The absence of uPAR is associated with the progression of dermal fibrosis","author":"Kanno","year":"2008","journal-title":"J Invest Dermatol"},{"key":"ref281","first-page":"2737","article-title":"den classification criteria for systemic sclerosis : an American College of Rheumatology European League against Rheumatism collaborative initiative","author":"van","year":"2013","journal-title":"Arthritis Rheum"},{"key":"ref291","first-page":"202","article-title":"systemic sclerosis classification subsets pathogenesis","volume":"15","author":"LeRoy","year":"1988","journal-title":"J Rheumatol"},{"key":"ref51","first-page":"3","article-title":"deficiency of uPAR alters endothelial angiogenic function and cell morphology","author":"Balsara","year":"2011","journal-title":"Cell"},{"key":"ref71","first-page":"128","article-title":"The absence of uPAR is associated with the progression of dermal fibrosis","author":"Kanno","year":"2008","journal-title":"J Invest Dermatol"},{"key":"ref311","first-page":"87","article-title":"genetic variation located in the promoter region of the CD gene is associated with the vascular complications of systemic sclerosis","author":"Manetti","year":"2011","journal-title":"Arthritis Rheum"},{"key":"ref11","first-page":"122","article-title":"The significance of interleukin reactive protein in systemic sclerosis : a systematic literature","volume":"31","author":"Muangchan","year":"2013","journal-title":"review Clin Exp Rheumatol"},{"key":"ref231","first-page":"3","article-title":"deficiency of uPAR alters endothelial angiogenic function and cell morphology","author":"Balsara","year":"2011","journal-title":"Cell"},{"key":"ref261","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1091\/mbc.e06-10-0912","article-title":"Urokinase receptor cleavage : a crucial step in fibroblast - to - myofibroblast 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Dis"},{"key":"ref201","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/ar4349","article-title":"Decreased expression of the endothelial cell - derived factor in systemic sclerosis : potential contribution to impaired angiogenesis and vasculogenesis","volume":"15","author":"Manetti","year":"2013","journal-title":"Arthritis Res Ther"},{"key":"ref301","first-page":"73","article-title":"Inactivation of urokinase - type plasminogen activator receptor uPAR gene induces dermal and pulmonary fibrosis and peripheral microvasculopathy in mice : a new model of experimental scleroderma","author":"Manetti","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"ref01","first-page":"117","article-title":"Systemic sclerosis a prototypic multisystem fibrotic disorder","author":"Varga","year":"2007","journal-title":"J Clin Invest"},{"key":"ref341","first-page":"1","article-title":"Del The fibrinolytic system components are increased in systemic sclerosis and modulated by Alprostadil alpha ciclodestryn","volume":"23","author":"Bandinelli","year":"2005","journal-title":"Clin Exp Rheumatol"},{"key":"ref161","first-page":"1","article-title":"Del The fibrinolytic system components are increased in systemic sclerosis and modulated by Alprostadil alpha ciclodestryn","volume":"23","author":"Bandinelli","year":"2005","journal-title":"Clin Exp Rheumatol"},{"key":"ref191","first-page":"122","article-title":"The significance of interleukin reactive protein in systemic sclerosis : a systematic literature","volume":"31","author":"Muangchan","year":"2013","journal-title":"review Clin Exp Rheumatol"},{"key":"ref101","first-page":"2737","article-title":"den classification criteria for systemic sclerosis : an American College of Rheumatology European League against Rheumatism collaborative initiative","author":"van","year":"2013","journal-title":"Arthritis Rheum"},{"key":"ref131","first-page":"87","article-title":"genetic variation located in the promoter region of the CD gene is 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receptor is required for its morphologic and functional \u03b2 integrin - mediated connection with actin cytoskeleton in human microvascular endothelial cells : failure of association in systemic sclerosis","author":"Margheri","year":"2006","journal-title":"Arthritis Rheum"},{"key":"ref31","article-title":"Increased serum levels and tissue expression of matrix metalloproteinase in patients with systemic sclerosis : correlation with severity of skin and pulmonary fibrosis and vascular damage","volume":"12","author":"Manetti","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/ar4349","article-title":"Decreased expression of the endothelial cell - derived factor in systemic sclerosis : potential contribution to impaired angiogenesis and vasculogenesis","volume":"15","author":"Manetti","year":"2013","journal-title":"Arthritis Res 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