{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T09:57:04Z","timestamp":1692611824114},"reference-count":42,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immunoglobulin \u03ba and \u03bb free light chains (FLC) are important serum biomarkers for diagnosing and monitoring plasma cell dyscrasias (via the \u03ba:\u03bb FLC ratio), and assessing immune competence and activation status (via \u2211FLC). FLCs are produced, in excess of heavy chains, from healthy plasma cells during immunoglobulin production, but unlike intact immunoglobulins that are cleared by cellular catabolism over a number of weeks, FLC are rapidly cleared from the bloodstream by the renal glomerulus with a half-life of 3 (\u03ba FLC)\u20136 (\u03bb FLC) hours. Marathon running has been shown to acutely and transiently decrease renal function, however, the impact of prolonged aerobic exercise on FLC levels remains unknown.<\/jats:p><jats:p>We measured serum FLC levels in 60 runners before, and immediately after, the 2010 Eindhoven Marathon.<\/jats:p><jats:p>A significant increase (p&lt;0.01) in \u03ba FLC levels was observed after the marathon, and \u03ba FLC correlated positively with serum creatinine levels. No changes were observed for \u03bb FLC, and thus, there were subtle elevations in the \u2211FLC and FLC ratio in some participants. Indeed, we found that 13% of participants had an abnormally increased FLC ratio upon completion of the marathon; a phenomenon previously observed in renal diseases.<\/jats:p><jats:p>Abnormal FLC ratios observed after exercise reflected an increase in serum \u03ba FLC levels, which may be due to acute and transient reductions in renal function during exercise, though we also observed an increase in serum IgG and IgA and thus cannot exclude exercise-induced immune stimulation or immunoglobulin redistribution.<\/jats:p>","DOI":"10.1515\/cclm-2015-0431","type":"journal-article","created":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T18:03:58Z","timestamp":1440439438000},"source":"Crossref","is-referenced-by-count":6,"title":["Assessment of serum free light chain levels in healthy adults immediately after marathon running"],"prefix":"10.1515","volume":"54","author":[{"given":"John P.","family":"Campbell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thijs M.H.","family":"Eijsvogels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria T.E.","family":"Hopman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joannes F.M.","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref11","first-page":"2015","article-title":"Elevation of serum immunoglobulin free light chains during the preclinical period of rheumatoid arthritis","author":"Deng","journal-title":"J Rheumatol"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.bbi.2012.02.004","article-title":"Vaccination response following aerobic exercise : can a brisk walk enhance antibody response to pneumococcal and influenza vaccinations","volume":"26","author":"Long","year":"2012","journal-title":"Brain Behav Immun"},{"key":"ref391","first-page":"454","article-title":"Rapid test to identity myeloma kidney by measurement of serum free light chains","volume":"13","author":"Campbell","year":"2013","journal-title":"Clin Lymphoma"},{"key":"ref411","first-page":"115","article-title":"Physical exercise in patients with severe kidney disease","author":"Kosmadakis","year":"2010","journal-title":"Nephron Clin Pract"},{"key":"ref161","first-page":"853","article-title":"Latex FLC serum free light - 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