{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T17:51:24Z","timestamp":1648576284745},"reference-count":34,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Accurate measurement of IgA monoclonal proteins presents a significant challenge to laboratory staff. IgA heavy\/light chain (Hevylite, HLC) analysis is an alternative methodology for monoclonal protein assessment, giving an independent measure of IgA\u03ba and IgA\u03bb concentrations. Clonality is assessed by calculating the ratio of involved immunoglobulin to background uninvolved immunoglobulin concentrations (e.g. IgA\u03ba\/IgA\u03bb in an IgA\u03ba patient). Here we discuss the challenges faced by the laboratory in IgA monoclonal protein assessment, and compare the performance of Hevylite assays with electrophoresis and total IgA results. We present data which validates the use of Hevylite for response assessment: in most cases, Hevylite provides comparable response assignment to that provided by serum protein electrophoresis (SPE) and total IgA; in other cases Hevylite provides additional information, such as detection of residual disease or relapse.<\/jats:p>","DOI":"10.1515\/cclm-2015-0696","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T20:47:24Z","timestamp":1445374044000},"source":"Crossref","is-referenced-by-count":4,"title":["Quantification of \u03b2-region IgA monoclonal proteins \u2013 should we include immunochemical Hevylite\u00ae measurements? Point"],"prefix":"10.1515","volume":"54","author":[{"given":"Josie A.R.","family":"Evans","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen L.","family":"Jenner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugh D.","family":"Carr Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Berlanga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Harding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref201","doi-asserted-by":"crossref","first-page":"3952","DOI":"10.1002\/cncr.28946","article-title":"IgA kappa\/IgA lambda heavy\/light chain assessment in the management of patients with IgA 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