{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:08:49Z","timestamp":1790813329470,"version":"4.1.0"},"reference-count":34,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Cerebrospinal fluid (CSF) leakage is a rare condition that can potentially lead to the development of serious complications. In the last decade, \u03b2-trace protein (\u03b2-TP) has been shown to be a valuable immunological biomarker that allows prompt and non-invasive identification of CSF leakage. At our institution, the measurement of \u03b2-TP has been included in the diagnostic work-up of CSF leakage for more than 10 years. According to our diagnostic algorithm, the presence of CSF in secretion is excluded when \u03b2-TP values are &lt;0.7 mg\/L, whereas \u03b2-TP values \u22651.3 mg\/L indicate the presence of CSF in secretion. \u03b2-TP values between 0.7 and 1.29 mg\/L indicate the presence of CSF if the \u03b2-TP ratio (\u03b2-TP secretion\/\u03b2-TP serum) is \u22652. This study aimed to validate this diagnostic algorithm using clinically defined nasal\/ear secretions.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>We performed a retrospective statistical analysis of three \u03b2-TP interpretation strategies using data of 236 samples originating from 121 patients with suspect CSF leakage received at our laboratory between 2004 and 2012.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>The highest odds ratio was obtained when the proposed algorithm has been used for the interpretation of \u03b2-TP results, showing a sensitivity of 98.3% and a specificity of 96%. Positive and negative predictive values were 89.2% and 99.4%, respectively.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions:<\/jats:title>\n<jats:p>Our data suggest that the proposed \u03b2-TP interpretation algorithm is a valuable tool for the diagnosis of CSF leakage in the clinical practice.<\/jats:p>\n<\/jats:sec>","DOI":"10.1515\/cclm-2016-0442","type":"journal-article","created":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T12:56:36Z","timestamp":1474548996000},"source":"Crossref","is-referenced-by-count":26,"title":["Retrospective validation of a \u03b2-trace protein interpretation algorithm for the diagnosis of cerebrospinal fluid leakage"],"prefix":"10.1515","volume":"55","author":[{"given":"Luca","family":"Bernasconi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"P\u00f6tzl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Steuer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Dellweg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Metternich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas R.","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref11","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1080\/02688699646880","article-title":"Traumatic 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