{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:08:53Z","timestamp":1765609733675},"reference-count":72,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"j_cclm-2016-0658_s_999\"><jats:title id=\"d557296e30124\">Background:<\/jats:title><jats:p>Antibodies to saccharomyces cerevisiae (ASCA), antibodies to perinuclear anti-neutrophil cytoplasmic (pANCA), pancreatic autoantibodies (PAB) and antibodies against intestinal goblet cells (GAB) are important in diagnosing Crohn\u2019s disease (CD) and ulcerative colitis (UC). However, little is known about their diagnostic value in real clinical practice in China. This retrospective study aimed to present our 2-year clinical experience with those biomarkers in diagnosis of CD and UC.<\/jats:p><\/jats:sec><jats:sec id=\"j_cclm-2016-0658_s_998\"><jats:title id=\"d557296e30132\">Methods:<\/jats:title><jats:p>A total of 140 patients with UC, 128 patients with CD, and 224 patients with intestinal associated diseases as disease controls were included. Serum ASCA were determined by ELISA. Serum pANCA, GAB, and PAB were tested by indirect immunofluorescent assay. Retrospective review of laboratory results and clinical information was performed.<\/jats:p><\/jats:sec><jats:sec id=\"j_cclm-2016-0658_s_997\"><jats:title id=\"d557296e30140\">Results:<\/jats:title><jats:p>ASCA and ASCA+\/pANCA\u2212 showed poor abilities in differentiating CD from UC, CD from intestinal Beh\u00e7et\u2019s disease (BD), or CD from intestinal tuberculosis (ITB). In contrast, PAB exhibited good capacities in differentiating CD from UC, CD from intestinal BD, and CD from ITB. IgG pANCA demonstrated a high sensitivity and specificity in differentiating UC from CD. pANCA+\/ASCA\u2212 or pANCA+\/PAB\u2212 displayed a high sensitivity and specificity in differentiating UC from CD. GAB showed poor potential in differentiating UC from CD. PAB were positively correlated with early disease onset, ileocolonic disease, and perianal disease in CD patients.<\/jats:p><\/jats:sec><jats:sec id=\"j_cclm-2016-0658_s_996\"><jats:title id=\"d557296e30148\">Conclusions:<\/jats:title><jats:p>Our data suggest that pANCA and PAB are helpful in diagnosis of UC and CD, respectively, while ASCA and GAB were not. Our findings indicate a clear need for additional biomarkers for diagnosis of CD in China.<\/jats:p><\/jats:sec>","DOI":"10.1515\/cclm-2016-0658","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T10:01:17Z","timestamp":1478772077000},"page":"865-875","source":"Crossref","is-referenced-by-count":5,"title":["Retrospective evaluation of the clinical utility of serological biomarkers in Chinese patients with inflammatory bowel disease: 2-year clinical experience"],"prefix":"10.1515","volume":"55","author":[{"given":"Shulan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaojun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuiwen","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengchun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaming","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongzhe","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref331","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/MPG.0b013e318256b516","article-title":"Pancreatic autoantibodies and autoantibodies against goblet cells in pediatric patients with inflammatory bowel disease","volume":"55","year":"2012","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"ref481","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0016-5085(76)80163-1","article-title":"Development of a Crohn\u2019s disease activity index. 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