{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:26:44Z","timestamp":1762522004182,"version":"3.41.2"},"reference-count":27,"publisher":"Walter de Gruyter GmbH","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,26]]},"abstract":"<jats:title>Abstract:<\/jats:title>\n               <jats:sec id=\"j_cclm-2016-1049_s_999_w2aab3b7c11b1b6b1aab1c19b1Aa\">\n                  <jats:title id=\"d1339325e32268_w2aab3b7c11b1b6b1aab1c19b1aAa\">Background:<\/jats:title>\n                  <jats:p>Inappropriate laboratory test utilization can result in unnecessary patient testing and increased healthcare costs. While several thyroid function tests are available, thyroid-stimulating hormone (TSH) is recommended as the first-line test for investigating and monitoring thyroid dysfunction. We evaluate thyroid test utilization in Northern Alberta in terms of testing patterns, frequencies, and reflex cutpoints.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2016-1049_s_998_w2aab3b7c11b1b6b1aab1c19b2Aa\">\n                  <jats:title id=\"d1339325e32276_w2aab3b7c11b1b6b1aab1c19b2aAa\">Methods:<\/jats:title>\n                  <jats:p>This retrospective study analyzed thyroid test requests from January to December 2014. Each request was designated as appropriate or potentially inappropriate as per clinical practice guidelines and Choosing Wisely recommendations, and the frequencies of each testing pattern were calculated. Sub-analysis was performed to categorize testing patterns based on physician specialty. The number of test requests per patient was determined to assess the appropriateness of testing frequency. Receiver operating characteristic (ROC) curves were generated to define optimal TSH cutpoints for automatic reflex to FT4 testing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2016-1049_s_997_w2aab3b7c11b1b6b1aab1c19b3Aa\">\n                  <jats:title id=\"d1339325e32284_w2aab3b7c11b1b6b1aab1c19b3aAa\">Results:<\/jats:title>\n                  <jats:p>Of 752,217 test requests, approximately 10% were potentially inappropriate in terms of testing patterns. Free thyroxine (FT4) and free triiodothyronine (FT3) requested with TSH accounted for 59% of all potentially inappropriate test requests, and 49% of requests from endocrinologists (ENDO) were potentially inappropriate, occurring most frequently among those with less experience. Excessive testing frequencies were observed in 869 patients, accounting for 9382 test requests. Adjustment of our TSH reflex cutpoint would significantly increase specificity for identifying a low FT4 without compromising sensitivity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2016-1049_s_996_w2aab3b7c11b1b6b1aab1c19b4Aa\">\n                  <jats:title id=\"d1339325e32292_w2aab3b7c11b1b6b1aab1c19b4aAa\">Conclusions:<\/jats:title>\n                  <jats:p>This study suggests that questionable testing patterns, excessive testing frequencies, and suboptimal reflexive testing cutpoints contribute to inappropriate thyroid test utilization.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/cclm-2016-1049","type":"journal-article","created":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T06:44:36Z","timestamp":1489733076000},"page":"1898-1906","source":"Crossref","is-referenced-by-count":15,"title":["Evaluation of thyroid test utilization through analysis of population-level data"],"prefix":"10.1515","volume":"55","author":[{"given":"Jasmine","family":"Gill","sequence":"first","affiliation":[{"name":"Laboratory Medicine and Pathology , University of Alberta , Edmonton, AB , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vilte E.","family":"Barakauskas","sequence":"additional","affiliation":[{"name":"Laboratory Medicine and Pathology , University of Alberta , Edmonton, AB , Canada"},{"name":"Pathology and Laboratory Medicine, BC Children\u2019s Hospital , Vancouver, BC , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dylan","family":"Thomas","sequence":"additional","affiliation":[{"name":"Laboratory Medicine and Pathology , University of Alberta , Edmonton, AB , Canada"},{"name":"DynaLIFE Medical Labs , Edmonton, AB , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina","family":"Rodriguez-Capote","sequence":"additional","affiliation":[{"name":"Laboratory Medicine and Pathology , University of Alberta , Edmonton, AB , Canada"},{"name":"DynaLIFE Medical Labs , Edmonton, AB , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trefor","family":"Higgins","sequence":"additional","affiliation":[{"name":"Laboratory Medicine and Pathology , University of Alberta , Edmonton, AB , Canada"},{"name":"DynaLIFE Medical Labs , Edmonton, AB , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Don","family":"Zhang","sequence":"additional","affiliation":[{"name":"DynaLIFE Medical Labs , Edmonton, AB , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"VanSpronsen","sequence":"additional","affiliation":[{"name":"Laboratory Medicine and Pathology , University of Alberta , Edmonton, AB , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oksana","family":"Babenko","sequence":"additional","affiliation":[{"name":"Family Medicine , University of Alberta , Edmonton, AB , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Martindale","sequence":"additional","affiliation":[{"name":"Laboratory Medicine and Pathology , University of Alberta , Edmonton, AB , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathew P.","family":"Estey","sequence":"additional","affiliation":[{"name":"Laboratory Medicine and Pathology , University of Alberta , Edmonton, AB , Canada"},{"name":"DynaLIFE Medical Labs , Edmonton, AB , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2017,3,15]]},"reference":[{"key":"2025071610275556229_j_cclm-2016-1049_ref_001_w2aab3b7c11b1b6b1ab1b6b1Aa","doi-asserted-by":"crossref","unstructured":"Huck A, Lewandrowski K. 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