{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:44:38Z","timestamp":1791575078293,"version":"4.3.4"},"reference-count":26,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,11,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_cclm-2017-0132_s_999_w2aab3b7c32b1b6b1aab1c16b1Aa\">\n                  <jats:title>Background:<\/jats:title>\n                  <jats:p>The Sysmex DI-60 system (DI-60, Sysmex, Kobe, Japan) is a new automated digital cell imaging analyzer. We explored the performance of DI-60 in comparison with Sysmex XN analyzer (XN, Sysmex) and manual count.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2017-0132_s_998_w2aab3b7c32b1b6b1aab1c16b2Aa\">\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>In a total of 276 samples (176 abnormal and 100 normal samples), white blood cell (WBC) differentials, red blood cell (RBC) classification and platelet (PLT) estimation by DI-60 were compared with the results by XN and\/or manual count. RBC morphology between pre-classification and verification was compared according to the ICSH grading criteria. The manual count was performed according to the Clinical and Laboratory Standards Institute guidelines (H20-A2).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2017-0132_s_997_w2aab3b7c32b1b6b1aab1c16b3Aa\">\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>The overall concordance between DI-60 and manual count for WBCs was 86.0%. The agreement between DI-60 pre-classification and verification was excellent (weighted \u03ba=0.963) for WBC five-part differentials. The correlation with manual count was very strong for neutrophils (r=0.955), lymphocytes (r=0.871), immature granulocytes (r=0.820), and blasts (r=0.879). RBC grading showed notable differences between DI-60 and manual counting on the basis of the ICSH grading criteria. Platelet count by DI-60 highly correlated with that by XN (r=0.945). However, DI-60 underestimated platelet counts in samples with marked thrombocytosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2017-0132_s_996_w2aab3b7c32b1b6b1aab1c16b4Aa\">\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>The performance of DI-60 for WBC differential, RBC classification, and platelet estimation seems to be acceptable even in abnormal samples with improvement after verification. DI-60 would help optimize the workflow in hematology laboratory with reduced manual workload.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/cclm-2017-0132","type":"journal-article","created":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T07:53:57Z","timestamp":1499068437000},"page":"94-102","source":"Crossref","is-referenced-by-count":51,"title":["Performance of automated digital cell imaging analyzer Sysmex DI-60"],"prefix":"10.1515","volume":"56","author":[{"given":"Hyeong Nyeon","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine , Konkuk University School of Medicine , Seoul , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Hur","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine , Konkuk University School of Medicine, Konkuk University Medical Center , 120-1, Neungdong-ro, Hwayang-dong, Gwangjin-gu, Seoul 05030, Republic of Korea , Phone: +82-2-2030-5581, Fax: +82-2-2636-6764"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanah","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine , Konkuk University School of Medicine , Seoul , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Wan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine , Konkuk University School of Medicine , Seoul , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee-Won","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine , Konkuk University School of Medicine , Seoul , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeo-Min","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine , Konkuk University School of Medicine , Seoul , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2017,6,16]]},"reference":[{"key":"2024112819260440680_j_cclm-2017-0132_ref_001_w2aab3b7c32b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Hur M, Cho JH, Kim H, Hong MH, Moon HW, Yun YM, et al. 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