{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:01:31Z","timestamp":1761663691990,"version":"3.40.5"},"reference-count":21,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_cclm-2017-0692_s_999_w2aab3b7c76b1b6b1aab1c16b1Aa\">\n                  <jats:title>Background:<\/jats:title>\n                  <jats:p>Uridine diphosphate glycosyltransferases 1A1 (UGT1A1) plays an essential role in detoxification and excretion of several endogenous and exogenous compounds. A functional polymorphism in the promoter of the <jats:italic>UGT1A1<\/jats:italic> gene (TA repeat insertion, <jats:italic>UGT1A1<\/jats:italic>*28, rs3064744) has been associated with reduced <jats:italic>UGT1A1<\/jats:italic> enzyme activity. The purpose of the present study was to investigate the role of <jats:italic>UGT1A1<\/jats:italic> genotypes in mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2017-0692_s_998_w2aab3b7c76b1b6b1aab1c16b2Aa\">\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>\n                     <jats:italic>UGT1A1<\/jats:italic> genotypes as well as baseline plasma bilirubin levels were analyzed in participants of the Ludwigshafen Risk and Cardiovascular Health study (n=3316). <jats:italic>UGT1A1<\/jats:italic>*28 genotypes were determined on an ABI PRISM 3730 genetic analyzer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2017-0692_s_997_w2aab3b7c76b1b6b1aab1c16b3Aa\">\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>As expected, <jats:italic>UGT1A1<\/jats:italic> genotypes were associated with baseline bilirubin levels (*1\/*1 genotype: 9.1\u00b14.6 \u00b5mol\/L; *1\/*28 genotype: 10.8\u00b15.3; *28\/*28: 16.9\u00b19.2; p&lt;0.001). During a median follow-up of 10.4 years, 995 subjects (30.0%) died. In a multivariate regression analysis adjusting for age, sex, smoking, type 2 diabetes, dyslipidemia, alanine aminotransferase (ALT) levels and bilirubin levels, the <jats:italic>UGT1A1<\/jats:italic>*28 variant predicted lower overall mortality (hazard ratio [HR], 0.86; 95% confidence interval [CI], 0.78\u20130.95; p=0.003). Contrary to expected, higher baseline bilirubin levels predicted increased mortality (HR, 1.014; 95% CI, 1.002\u20131.025; p=0.019).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2017-0692_s_996_w2aab3b7c76b1b6b1aab1c16b4Aa\">\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>The <jats:italic>UGT1A1<\/jats:italic>*28 gene variant is associated with lower mortality rates. The protective effect of the <jats:italic>UGT1A1<\/jats:italic>*28 variant likely includes mechanism other than bilirubin metabolism.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/cclm-2017-0692","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T22:16:16Z","timestamp":1512684976000},"page":"560-564","source":"Crossref","is-referenced-by-count":5,"title":["The <i>UGT1A1<\/i>*28 gene variant predicts long-term mortality in patients undergoing coronary angiography"],"prefix":"10.1515","volume":"56","author":[{"given":"Barbara","family":"Zulus","sequence":"first","affiliation":[{"name":"Clinical Institute of Medical and Chemical Laboratory Diagnostics , Medical University Graz , Graz , Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerda","family":"Gr\u00fcnbacher","sequence":"additional","affiliation":[{"name":"Clinical Institute of Medical and Chemical Laboratory Diagnostics , Medical University Graz , Graz , Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus E.","family":"Kleber","sequence":"additional","affiliation":[{"name":"Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology) , Medical Faculty Mannheim , University of Heidelberg , Mannheim , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winfried","family":"M\u00e4rz","sequence":"additional","affiliation":[{"name":"Clinical Institute of Medical and Chemical Laboratory Diagnostics , Medical University Graz , Graz , Austria"},{"name":"Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology) , Medical Faculty Mannheim , University of Heidelberg , Mannheim , Germany"},{"name":"Synlab Academy, Synlab Holding Deutschland GmbH , Mannheim , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6199-4382","authenticated-orcid":false,"given":"Wilfried","family":"Renner","sequence":"additional","affiliation":[{"name":"Clinical Institute of Medical and Chemical Laboratory Diagnostics , Medical University Graz , Graz , Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2017,12,7]]},"reference":[{"key":"2022030300261114751_j_cclm-2017-0692_ref_001_w2aab3b7c76b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Sugatani J. 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