{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:51:11Z","timestamp":1781765471752,"version":"3.54.5"},"reference-count":42,"publisher":"Walter de Gruyter GmbH","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,26]]},"abstract":"Abstract<\/jats:title>\n\nBackground:<\/jats:title>\nWe evaluated the clinical performance of the Minicare cardiac troponin-I (cTnI), a new point-of-care (POC) cTnI test for the diagnosis of acute myocardial infarction (AMI) in a prospective, multicentre study (ISRCTN77371338).<\/jats:p><\/jats:sec>\n\nMethods:<\/jats:title>\nOf 474 patients (\u226518 years) admitted to an emergency department (ED) or chest pain unit (CPU) with symptoms suggestive of acute coronary syndrome (ACS; \u226412 h from symptom onset), 465 were eligible. Minicare cTnI was tested immediately, 3 h and 6 h after presentation. AMI diagnoses were adjudicated independently based on current guidelines.<\/jats:p><\/jats:sec>\n\nResults:<\/jats:title>\nThe diagnostic performance of the Minicare cTnI test at 3 h was similar for whole blood and in plasma: sensitivity 0.92 vs. 0.90; specificity 0.91 vs. 0.90; positive predictive value (PPV) 0.68 vs. 0.66; negative predictive value (NPV) 0.98 vs. 0.98; positive likelihood ratio (LR+) 10.18 vs. 9.41; negative likelihood ratio (LR\u2013) 0.09 vs. 0.11. The optimal diagnostic performance was obtained at 3 h using cut-offs cTnI >43 ng\/L plus cTnI change from admission \u226518.5 ng\/L: sensitivity 0.90, specificity 0.96, PPV 0.81, NPV 0.98, and LR+ 21.54. The area under the receiver operating characteristics (ROC) curve for cTnI whole blood baseline value and absolute change after 3 h curve was 0.93.<\/jats:p><\/jats:sec>\n\nConclusions:<\/jats:title>\nThese data support the clinical usefulness of Minicare cTnI within a 0 h\/3 h-blood sampling protocol supported by current guidelines for the evaluation of suspected ACS.<\/jats:p><\/jats:sec>","DOI":"10.1515\/cclm-2017-0693","type":"journal-article","created":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T08:47:04Z","timestamp":1523522824000},"page":"1336-1344","source":"Crossref","is-referenced-by-count":5,"title":["Clinical performance of a new point-of-care cardiac troponin I test"],"prefix":"10.1515","volume":"56","author":[{"given":"Michael","family":"Christ","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicitas","family":"Geier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Blaschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Giannitsis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Khellaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Mair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Pariente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volkher","family":"Scharnhorst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronique","family":"Semjonow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Hausfater","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref41","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/j.clinbiochem.2013.06.026","article-title":"Diagnostic 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