{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:57:33Z","timestamp":1791932253193,"version":"4.3.4"},"reference-count":56,"publisher":"Walter de Gruyter GmbH","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,10,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"j_cclm-2018-0471_s_999\">\n<jats:title id=\"d745630e77009\">Background:<\/jats:title>\n<jats:p>This study\u2019s primary objective was to validate the routine use of S100B via a prospective study. The aim was a reduction of cranial computed tomography (CCT) scans by 30%. The secondary goal was to investigate the influence of age and associated risk factors on the reduction of CCT.<\/jats:p><\/jats:sec>\n<jats:sec id=\"j_cclm-2018-0471_s_998\">\n<jats:title id=\"d745630e77017\">Methods:<\/jats:title>\n<jats:p>S100B (sampling within 3 h postinjury) was used for patients with mild traumatic brain injury (mTBIs) presenting a medium risk of complications and requiring a CCT scan. Patients with negative S100B (S100B\u2212) were discharged without a CCT scan.<\/jats:p><\/jats:sec>\n<jats:sec id=\"j_cclm-2018-0471_s_997\">\n<jats:title id=\"d745630e77025\">Results:<\/jats:title>\n<jats:p>Of the 1449 patients included in this study, 468 (32.3%) had S100B\u2212 with a sensitivity of 96.4% (95% CI: 87.5%\u201399.6%), a specificity of 33.4% (95% CI: 31%\u201336%) and a negative predictive value of 99.6% (95% CI: 98.5%\u201399.9%). No significant difference in serum levels or the S100B+ rate was observed if patients had retrograde amnesia (0.16 \u03bcg\/L; 63.8%), loss of consciousness (0.13; 63.6%) or antiplatelet therapy (0.20; 77.9%). Significant differences were found between the S100B concentrations and S100B positivity rates in patients &gt;65 years old and all the groups with patients &lt;55 years old (18\u201325, 26\u201335, 36\u201345 and 46\u201355). From 18 to 65 years old (n=874), the specificity is 39.3% (95% CI: 36%\u201342.6%) compared to 18.7% (95% CI: 15.3%\u201322.3%) for patients &gt;65 years old (n=504).<\/jats:p><\/jats:sec>\n<jats:sec id=\"j_cclm-2018-0471_s_996\">\n<jats:title id=\"d745630e77033\">Conclusions:<\/jats:title>\n<jats:p>The clinical use of S100B in mTBI management reduces the use of CCTs by approximately one-third; furthermore, the percentage of CCTs reduction is influenced by the age of the patient.<\/jats:p><\/jats:sec>","DOI":"10.1515\/cclm-2018-0471","type":"journal-article","created":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T22:16:11Z","timestamp":1529532971000},"page":"1897-1904","source":"Crossref","is-referenced-by-count":41,"title":["Clinical validation of S100B in the management of a mild traumatic brain injury: issues from an interventional cohort of 1449 adult patients"],"prefix":"10.1515","volume":"56","author":[{"given":"Gautier","family":"Allouchery","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Far\u00e8s","family":"Moustafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Roubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannot","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Raconnat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Pic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Sapin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Bouvier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref91","doi-asserted-by":"crossref","first-page":"pii: 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