{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T06:13:32Z","timestamp":1775283212331,"version":"3.50.1"},"reference-count":64,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_cclm-2018-0909_s_999\">\n                    <jats:title id=\"d4336481e81459\">Background<\/jats:title>\n                    <jats:p>Platelet-neutrophil aggregates (PNAs) are fundamental mechanisms linking hemostasis and inflammatory processes. Elevated level of PNAs have been reported in inflammatory diseases and coronary artery diseases. However, studies on the correlation between PNAs formation and deep venous thrombosis (DVT) are not available.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2018-0909_s_998\">\n                    <jats:title id=\"d4336481e81467\">Methods<\/jats:title>\n                    <jats:p>\n                      A total of 92 participants were involved in this study, including 32 cases with DVT and 60 cases without DVT. Blood samples coagulated by K\n                      <jats:sub>2<\/jats:sub>\n                      -EDTA or sodium citrate were prepared for blood cell count and blood smears. PNAs and platelet activation were measured using flow cytometry. The correlation between platelet activation level and PNAs level was analyzed by linear regression. Receiver operating characteristic (ROC) analysis was performed, assessing the prognostic performance of PNAs to predict potential risk of DVT occurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2018-0909_s_997\">\n                    <jats:title id=\"d4336481e81478\">Results<\/jats:title>\n                    <jats:p>\n                      PNAs was found in the blood smears of patients with DVT. Significant increased level of PNAs was identified in DVT group (medium 8.43%, interquartile range [IQR] 4.11%\u201315.69%), compared with that in control group (5.16%, IQR 2.40\u20139.60, p&lt;0.01). The DVT group also showed a dramatic elevated level of total platelet activation (medium 16.06%, IQR 6.04\u201322.05) vs. control group (11.26%, IQR 5.54\u201319.99, p&lt;0.05). The PNAs level was correlated with total platelet activation (r\n                      <jats:sup>2<\/jats:sup>\n                      =0.58, p&lt;0.0001). A significantly high odds ratio (OR) of DVT occurrence was identified when the level of PNAs was higher than 7.4% (OR 3.60, 95% confidence interval [CI] 1.463\u20138.838, p&lt;0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2018-0909_s_996\">\n                    <jats:title id=\"d4336481e81489\">Conclusions<\/jats:title>\n                    <jats:p>An elevated level of PNAs was associated with risk of DVT occurrence, which might be a suitable marker predicting DVT development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/cclm-2018-0909","type":"journal-article","created":{"date-parts":[[2018,11,24]],"date-time":"2018-11-24T04:01:16Z","timestamp":1543032076000},"page":"707-715","source":"Crossref","is-referenced-by-count":33,"title":["Circulating platelet-neutrophil aggregates as risk factor for deep venous thrombosis"],"prefix":"10.1515","volume":"57","author":[{"given":"Jingyi","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erwen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref421","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.intimp.2013.06.004","article-title":"Neutrophil and platelet complexes and their relevance to neutrophil recruitment and activation","volume":"17","year":"2013","journal-title":"Int Immunopharmacol"},{"key":"ref221","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1253\/circj.CJ-14-1323","article-title":"Circulating platelet-neutrophil aggregates play a significant role in Kawasaki disease","volume":"79","year":"2015","journal-title":"Circ J"},{"key":"ref461","doi-asserted-by":"crossref","first-page":"G1054","DOI":"10.1152\/ajpgi.00350.2007","article-title":"Mechanisms of platelet and leukocyte recruitment in experimental colitis","volume":"293","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref521","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1475-2840-2-2","article-title":"Is type 2 diabetes mellitus a vascular disease (atheroscleropathy) with hyperglycemia a late manifestation? The role of NOS, NO, and redox stress","volume":"2","year":"2003","journal-title":"Cardiovasc Diabetol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1084\/jem.20112322","article-title":"Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo","volume":"209","year":"2012","journal-title":"J Exp Med"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1161\/CIRCULATIONAHA.110.014555","article-title":"Phosphorylation of vasodilator-stimulated phosphoprotein prevents platelet-neutrophil complex formation and dampens myocardial ischemia-reperfusion injury","volume":"123","year":"2011","journal-title":"Circulation"},{"key":"ref351","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1161\/ATVBAHA.111.242818","article-title":"Mechanistic view of risk factors for venous thromboembolism","volume":"32","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref491","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1161\/CIRCULATIONAHA.110.014555","article-title":"Phosphorylation of vasodilator-stimulated phosphoprotein prevents platelet-neutrophil complex formation and dampens myocardial ischemia-reperfusion injury","volume":"123","year":"2011","journal-title":"Circulation"},{"key":"ref591","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.thromres.2010.05.012","article-title":"Leukocytosis, thrombosis and early mortality in cancer patients initiating chemotherapy","volume":"126","year":"2010","journal-title":"Thromb Res"},{"key":"ref571","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.amjms.2016.05.034","article-title":"Increased platelet-leukocyte aggregates are associated with myocardial no-reflow in patients with ST elevation myocardial infarction","volume":"352","year":"2016","journal-title":"Am J Med Sci"},{"key":"ref311","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1189\/jlb.3TA0315-082R","article-title":"Platelet-neutrophil complex formation-a detailed in vitro analysis of murine and human blood samples","volume":"99","year":"2016","journal-title":"J Leukoc Biol"},{"key":"ref01","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1053\/ejvs.2002.1778","article-title":"Incidence of diagnosed deep vein thrombosis in the general population: systematic review","volume":"25","year":"2003","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/S0022-3565(24)29425-8","article-title":"P-selectin antagonism with recombinant p-selectin glycoprotein ligand-1 (rPSGL-Ig) inhibits circulating activated platelet binding to neutrophils induced by damaged arterial surfaces","volume":"298","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"ref551","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1172\/JCI29499","article-title":"Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation","volume":"116","year":"2006","journal-title":"J Clin Invest"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/nm.2184","article-title":"Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases","volume":"16","year":"2010","journal-title":"Nat Med"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.2353\/ajpath.2007.060881","article-title":"The role of platelets in leukocyte recruitment in chronic contact hypersensitivity induced by repeated elicitation","volume":"170","year":"2007","journal-title":"Am J Pathol"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1046\/j.1365-2141.1999.01553.x","article-title":"Circulating platelet-neutrophil complexes represent a subpopulation of activated neutrophils primed for adhesion, phagocytosis and intracellular killing","volume":"106","year":"1999","journal-title":"Br J Haematol"},{"key":"ref371","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/nm.2184","article-title":"Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases","volume":"16","year":"2010","journal-title":"Nat Med"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.intimp.2013.06.004","article-title":"Neutrophil and platelet complexes and their relevance to neutrophil recruitment and activation","volume":"17","year":"2013","journal-title":"Int Immunopharmacol"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1161\/01.CIR.0000042674.89762.20","article-title":"Neutrophil infiltration of culprit lesions in acute coronary syndromes","volume":"106","year":"2002","journal-title":"Circulation"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"e39484","DOI":"10.1371\/journal.pone.0039484","article-title":"An intense and short-lasting burst of neutrophil activation differentiates early acute myocardial infarction from systemic inflammatory syndromes","volume":"7","year":"2012","journal-title":"PLoS One"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1182\/blood-2013-11-536003","article-title":"Platelet-TLR7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis","volume":"124","year":"2014","journal-title":"Blood"},{"key":"ref391","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1161\/ATVBAHA.112.300498","article-title":"Circulating nucleosomes and neutrophil activation as risk factors for deep vein thrombosis","volume":"33","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref511","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1161\/01.CIR.0000042674.89762.20","article-title":"Neutrophil infiltration of culprit lesions in acute coronary syndromes","volume":"106","year":"2002","journal-title":"Circulation"},{"key":"ref631","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1189\/jlb.3TA0315-082R","article-title":"Platelet-neutrophil complex formation-a detailed in vitro analysis of murine and human blood samples","volume":"99","year":"2016","journal-title":"J Leukoc Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1538-7836.2007.02450.x","article-title":"Incidence and mortality of venous thrombosis: a population-based study","volume":"5","year":"2007","journal-title":"J Thromb Haemost"},{"key":"ref341","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/jth.12261","article-title":"Crossroads of coagulation and innate immunity: the case of deep vein thrombosis","volume":"11","year":"2013","journal-title":"J Thromb Haemost"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1097\/CCM.0b013e31819ceb71","article-title":"Platelets support pulmonary recruitment of neutrophils in abdominal sepsis","volume":"37","year":"2009","journal-title":"Crit Care Med"},{"key":"ref411","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1152\/japplphysiol.01086.2009","article-title":"Circulating platelet-neutrophil complexes are important for subsequent neutrophil activation and migration","volume":"109","year":"2010","journal-title":"J Appl Physiol (1985)"},{"key":"ref381","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1084\/jem.20112322","article-title":"Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo","volume":"209","year":"2012","journal-title":"J Exp Med"},{"key":"ref281","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1538-7836.2011.04544.x","article-title":"Neutrophil extracellular traps promote deep vein thrombosis in mice","volume":"10","year":"2012","journal-title":"J Thromb Haemost"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1161\/01.CIR.98.13.1322","article-title":"Synergism between platelets and neutrophils in provoking cardiac dysfunction after ischemia and reperfusion: role of selectins","volume":"98","year":"1998","journal-title":"Circulation"},{"key":"ref301","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/s11239-015-1212-8","article-title":"Platelet leukocyte aggregates and markers of platelet aggregation, immune activation and disease progression in HIV infected treatment naive asymptomatic individuals","volume":"40","year":"2015","journal-title":"J Thromb Thrombolysis"},{"key":"ref271","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.thromres.2010.05.012","article-title":"Leukocytosis, thrombosis and early mortality in cancer patients initiating chemotherapy","volume":"126","year":"2010","journal-title":"Thromb Res"},{"key":"ref201","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1475-2840-2-2","article-title":"Is type 2 diabetes mellitus a vascular disease (atheroscleropathy) with hyperglycemia a late manifestation? The role of NOS, NO, and redox stress","volume":"2","year":"2003","journal-title":"Cardiovasc Diabetol"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/nm810","article-title":"Circulating activated platelets exacerbate atherosclerosis in mice deficient in mice deficient in apolipoprotein E","volume":"9","year":"2003","journal-title":"Nat Med"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1002\/ajh.20655","article-title":"Increased circulating platelet-neutrophil, platelet-monocyte complexes, and platelet activation in patients with ulcerative colitis: a comparative study","volume":"81","year":"2006","journal-title":"Am J Hematol"},{"key":"ref611","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1016\/j.febslet.2010.06.006","article-title":"Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis-mediated cell death","volume":"584","year":"2010","journal-title":"FEBS Lett"},{"key":"ref401","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/S0022-3565(24)29425-8","article-title":"P-selectin antagonism with recombinant p-selectin glycoprotein ligand-1 (rPSGL-Ig) inhibits circulating activated platelet binding to neutrophils induced by damaged arterial surfaces","volume":"298","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1161\/ATVBAHA.112.300498","article-title":"Circulating nucleosomes and neutrophil activation as risk factors for deep vein thrombosis","volume":"33","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref251","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.amjms.2016.05.034","article-title":"Increased platelet-leukocyte aggregates are associated with myocardial no-reflow in patients with ST elevation myocardial infarction","volume":"352","year":"2016","journal-title":"Am J Med Sci"},{"key":"ref321","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1053\/ejvs.2002.1778","article-title":"Incidence of diagnosed deep vein thrombosis in the general population: systematic review","volume":"25","year":"2003","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"ref561","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1002\/ajh.20655","article-title":"Increased circulating platelet-neutrophil, platelet-monocyte complexes, and platelet activation in patients with ulcerative colitis: a comparative study","volume":"81","year":"2006","journal-title":"Am J Hematol"},{"key":"ref601","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1538-7836.2011.04544.x","article-title":"Neutrophil extracellular traps promote deep vein thrombosis in mice","volume":"10","year":"2012","journal-title":"J Thromb Haemost"},{"key":"ref291","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1016\/j.febslet.2010.06.006","article-title":"Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis-mediated cell death","volume":"584","year":"2010","journal-title":"FEBS Lett"},{"key":"ref441","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1097\/CCM.0b013e31819ceb71","article-title":"Platelets support pulmonary recruitment of neutrophils in abdominal sepsis","volume":"37","year":"2009","journal-title":"Crit Care Med"},{"key":"ref581","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1182\/blood-2010-05-287623","article-title":"von Willebrand factor-mediated platelet adhesion is critical for deep vein thrombosis in mouse models","volume":"117","year":"2011","journal-title":"Blood"},{"key":"ref531","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1046\/j.1365-2141.1999.01553.x","article-title":"Circulating platelet-neutrophil complexes represent a subpopulation of activated neutrophils primed for adhesion, phagocytosis and intracellular killing","volume":"106","year":"1999","journal-title":"Br J Haematol"},{"key":"ref431","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.2353\/ajpath.2007.060881","article-title":"The role of platelets in leukocyte recruitment in chronic contact hypersensitivity induced by repeated elicitation","volume":"170","year":"2007","journal-title":"Am J Pathol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/jth.12261","article-title":"Crossroads of coagulation and innate immunity: the case of deep vein thrombosis","volume":"11","year":"2013","journal-title":"J Thromb Haemost"},{"key":"ref361","doi-asserted-by":"crossref","first-page":"15880","DOI":"10.1073\/pnas.1005743107","article-title":"Extracellular DNA traps promote thrombosis","volume":"107","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref451","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1182\/blood-2013-11-536003","article-title":"Platelet-TLR7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis","volume":"124","year":"2014","journal-title":"Blood"},{"key":"ref501","doi-asserted-by":"crossref","first-page":"e39484","DOI":"10.1371\/journal.pone.0039484","article-title":"An intense and short-lasting burst of neutrophil activation differentiates early acute myocardial infarction from systemic inflammatory syndromes","volume":"7","year":"2012","journal-title":"PLoS One"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"G1054","DOI":"10.1152\/ajpgi.00350.2007","article-title":"Mechanisms of platelet and leukocyte recruitment in experimental colitis","volume":"293","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref481","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1161\/01.CIR.98.13.1322","article-title":"Synergism between platelets and neutrophils in provoking cardiac dysfunction after ischemia and reperfusion: role of selectins","volume":"98","year":"1998","journal-title":"Circulation"},{"key":"ref541","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1253\/circj.CJ-14-1323","article-title":"Circulating platelet-neutrophil aggregates play a significant role in Kawasaki disease","volume":"79","year":"2015","journal-title":"Circ J"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1152\/japplphysiol.01086.2009","article-title":"Circulating platelet-neutrophil complexes are important for subsequent neutrophil activation and migration","volume":"109","year":"2010","journal-title":"J Appl Physiol (1985)"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1161\/ATVBAHA.111.242818","article-title":"Mechanistic view of risk factors for venous thromboembolism","volume":"32","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"15880","DOI":"10.1073\/pnas.1005743107","article-title":"Extracellular DNA traps promote thrombosis","volume":"107","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref261","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1182\/blood-2010-05-287623","article-title":"von Willebrand factor-mediated platelet adhesion is critical for deep vein thrombosis in mouse models","volume":"117","year":"2011","journal-title":"Blood"},{"key":"ref331","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1538-7836.2007.02450.x","article-title":"Incidence and mortality of venous thrombosis: a population-based study","volume":"5","year":"2007","journal-title":"J Thromb Haemost"},{"key":"ref621","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/s11239-015-1212-8","article-title":"Platelet leukocyte aggregates and markers of platelet aggregation, immune activation and disease progression in HIV infected treatment naive asymptomatic individuals","volume":"40","year":"2015","journal-title":"J Thromb Thrombolysis"},{"key":"ref231","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1172\/JCI29499","article-title":"Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation","volume":"116","year":"2006","journal-title":"J Clin Invest"},{"key":"ref471","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/nm810","article-title":"Circulating activated platelets exacerbate atherosclerosis in mice deficient in mice deficient in apolipoprotein E","volume":"9","year":"2003","journal-title":"Nat Med"}],"container-title":["Clinical Chemistry and Laboratory Medicine (CCLM)"],"original-title":[],"link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/cclm.2019.57.issue-5\/cclm-2018-0909\/cclm-2018-0909.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/cclm-2018-0909\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T05:36:22Z","timestamp":1775280982000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/cclm-2018-0909\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,24]]},"references-count":64,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.1515\/cclm-2018-0909","relation":{},"ISSN":["1437-4331","1434-6621"],"issn-type":[{"value":"1437-4331","type":"electronic"},{"value":"1434-6621","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4,24]]}}}