{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:06:51Z","timestamp":1789639611789,"version":"4.0.0"},"reference-count":25,"publisher":"Walter de Gruyter GmbH","issue":"9","funder":[{"DOI":"10.13039\/100009045","name":"Jagiellonian University Medical College","doi-asserted-by":"publisher","award":["K\/ZDS\/007717"],"award-info":[{"award-number":["K\/ZDS\/007717"]}],"id":[{"id":"10.13039\/100009045","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_cclm-2018-1197_s_999_w2aab3b7c49b1b6b1aab1c16b1Aa\">\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Direct oral anticoagulants (DOACs) cause false positive lupus anticoagulant (LA) results. We assessed the impact of DOAC-Stop, reversing <jats:italic>in vitro<\/jats:italic> effects of DOACs, on LA testing in anticoagulated patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2018-1197_s_998_w2aab3b7c49b1b6b1aab1c16b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We assessed 75 venous thromboembolism patients aged 44.5\u00b114.6 years. Blood samples were collected 2\u201328 h since intake of DOACs, including 50 patients on rivaroxaban, 20 on dabigatran and five on apixaban. LA testing was performed at baseline and after DOAC-Stop treatment. Positive LA was defined as the normalized (patient\/standard plasma clotting time) LA screening and screening (LA1)\/confirmation (LA2) ratios exceeding 1.2.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2018-1197_s_997_w2aab3b7c49b1b6b1aab1c16b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>LA diluted Russell\u2019s viper venom time (dRVVT) normalized screening test revealed abnormal results in 73 (97.3%) and activated partial thromboplastin time (APTT)-LA in 49 (65.3%) patients. In six (8%) patients, antiphospholipid syndrome (APS) was diagnosed. dRVVT LA1\/LA2 was abnormal in 35 (50.7%) patients taking DOACs. The APTT ratio was normal in all studied subjects. DOAC-Stop completely removed dabigatran and reduced by 98% rivaroxaban and by 92.3% apixaban concentrations (all p&lt;0.05). After DOAC-Stop screening dRVVT remained prolonged in 34 (49.3%) patients (p&lt;0.001), while dRVVT LA1\/LA2 was abnormal in six (8.7%) subjects, with no association with DOAC concentrations at baseline and after DOAC-Stop. The APTT-LA screening test remained prolonged in five (7.2%) patients, while the APTT LA1\/LA2 ratio was normal in those subjects. DOAC-Stop did not influence LA testing in APS patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2018-1197_s_996_w2aab3b7c49b1b6b1aab1c16b4Aa\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Application of DOAC-Stop effectively reduced plasma DOAC concentrations leading to appropriate dRVVT results in up to 97% of VTE patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/cclm-2018-1197","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T09:01:10Z","timestamp":1550134870000},"page":"1374-1381","source":"Crossref","is-referenced-by-count":44,"title":["The effect of DOAC-Stop on lupus anticoagulant testing in plasma samples of venous thromboembolism patients receiving direct oral anticoagulants"],"prefix":"10.1515","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1762-308X","authenticated-orcid":false,"given":"Micha\u0142","family":"Z\u0105bczyk","sequence":"first","affiliation":[{"name":"Institute of Cardiology , Jagiellonian University Medical College and John Paul II Hospital , Krakow , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Kopytek","sequence":"additional","affiliation":[{"name":"Institute of Cardiology , Jagiellonian University Medical College and John Paul II Hospital , Krakow , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Natorska","sequence":"additional","affiliation":[{"name":"Institute of Cardiology , Jagiellonian University Medical College and John Paul II Hospital , Krakow , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anetta","family":"Undas","sequence":"additional","affiliation":[{"name":"Institute of Cardiology , Jagiellonian University Medical College and John Paul II Hospital , Krakow , Poland"},{"name":"Faculty of Medicine and Health Sciences , Jan Kochanowski University , Kielce , Poland , Phone: +48-12-6143004, Fax: +48-12-6142120"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2019,2,14]]},"reference":[{"key":"2023033110071932289_j_cclm-2018-1197_ref_001_w2aab3b7c49b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Pengo V, Tripodi A, Reber G, Rand JH, Ortel TL, Galli M, et al. Update of the guidelines for lupus anticoagulant detection. Subcommittee on Lupus Anticoagulant\/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the International Society on Thrombosis and Haemostasis. J Thromb Haemost 2009;7:1737\u201340.","DOI":"10.1111\/j.1538-7836.2009.03555.x"},{"key":"2023033110071932289_j_cclm-2018-1197_ref_002_w2aab3b7c49b1b6b1ab2b1b2Aa","doi-asserted-by":"crossref","unstructured":"Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006;4:295\u2013306.","DOI":"10.1111\/j.1538-7836.2006.01753.x"},{"key":"2023033110071932289_j_cclm-2018-1197_ref_003_w2aab3b7c49b1b6b1ab2b1b3Aa","doi-asserted-by":"crossref","unstructured":"Devreese KM, Ortel TL, Pengo V, de Laat B, Subcommittee on Lupus Anticoagulant\/Antiphospholipid Antibodies. 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