{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T12:46:24Z","timestamp":1787748384220,"version":"build-2784847793"},"reference-count":44,"publisher":"Walter de Gruyter GmbH","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_cclm-2019-0495_s_999_w2aab3b7d167b1b6b1aab1c17b1Aa\">\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Pregnancy introduces major physiological changes that also alter biochemical analytes. Maternal and perinatal health can be optimized by early intervention and therefore, pregnancy-specific reference intervals (RIs) for the local population are warranted. While the second and third trimester-specific changes are well described, the first trimester is less well characterized. We therefore wanted to facilitate early detection of abnormalities by generating first trimester reference values for 29 common analytes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2019-0495_s_998_w2aab3b7d167b1b6b1aab1c17b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In a prospective early pregnancy (PEP) cohort (2016\u20132017), 203 pregnant women were recruited from 4 to 8 weeks\u2019 gestation. Consecutive blood samples were drawn every 2 weeks until an ongoing second trimester pregnancy (n\u2009=\u2009164) or a miscarriage (n\u2009=\u200939) occurred. After exclusion of women with complicated pregnancies or deliveries (n\u2009=\u200942), 122 women were included. The serum samples collected at &lt;6, 6\u20138, 8\u201310, 10\u201312 and &gt;12 weeks\u2019 gestation were analyzed for 29 common analytes. Subsequently the RIs were calculated according to the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) recommendations (2.5\u201397.5th percentiles) and compared with the conventional RIs for non-pregnant women.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2019-0495_s_997_w2aab3b7d167b1b6b1aab1c17b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Human chorionic gonadotropin (hCG), progesterone (P4), estradiol (E2), pregnancy-associated plasma protein A (PAPP-A), cancer antigen 125 (CA125), thyroid stimulating hormone (TSH), creatinine (CREA) and albumin (ALB) showed an early pregnancy-dependent change compared with conventional limits. For ALB the change was seen at 5.5 weeks\u2019 gestation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2019-0495_s_996_w2aab3b7d167b1b6b1aab1c17b4Aa\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We report gestational age-specific RIs available from the early part of the first trimester applicable to everyday clinical care of pregnant women. Well-known alterations of RIs seen in later trimesters are also observed in the first.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/cclm-2019-0495","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T09:02:15Z","timestamp":1564045335000},"page":"1956-1967","source":"Crossref","is-referenced-by-count":31,"title":["Early pregnancy reference intervals; 29 serum analytes from 4 to 12 weeks\u2019 gestation in naturally conceived and uncomplicated pregnancies resulting in live births"],"prefix":"10.1515","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5619-1809","authenticated-orcid":false,"given":"Jesper","family":"Friis Petersen","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, North Zealand Hospital , University of Copenhagen , Hiller\u00f8d , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennart J.","family":"Friis-Hansen","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, North Zealand Hospital , University of Copenhagen , Hiller\u00f8d , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas Kryger","family":"Jensen","sequence":"additional","affiliation":[{"name":"Section of Biostatistics, Institute of Public Health , University of Copenhagen , Copenhagen , Denmark"},{"name":"Department of Clinical Research , North Zealand Hospital , Hiller\u00f8d , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Nyboe Andersen","sequence":"additional","affiliation":[{"name":"The Fertility Clinic, Rigshospitalet , Copenhagen University , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen C.L.","family":"L\u00f8kkegaard","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, North Zealand Hospital , University of Copenhagen , Hiller\u00f8d , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2019,7,25]]},"reference":[{"key":"2023033110125143366_j_cclm-2019-0495_ref_001_w2aab3b7d167b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Poon LC, McIntyre HD, Hyett JA, da Fonseca EB, Hod M. 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