{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T18:29:29Z","timestamp":1783535369565,"version":"3.55.0"},"reference-count":15,"publisher":"Walter de Gruyter GmbH","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,25]]},"DOI":"10.1515\/cclm-2020-0028","type":"journal-article","created":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T13:28:36Z","timestamp":1583933316000},"page":"e225-e227","source":"Crossref","is-referenced-by-count":3,"title":["Interference from immunocomplexes on a high-sensitivity cardiac troponin T immunoassay"],"prefix":"10.1515","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3263-6671","authenticated-orcid":false,"given":"Luca","family":"Dalle Carbonare","sequence":"first","affiliation":[{"name":"Department of Medicine, Section of Internal Medicine , University of Verona , Verona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Pizzini","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Internal Medicine , University of Verona , Verona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Micheletti","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Internal Medicine , University of Verona , Verona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Lo Cascio","sequence":"additional","affiliation":[{"name":"Service of Laboratory Medicine , University Hospital of Verona , Verona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Bovo","sequence":"additional","affiliation":[{"name":"Medical Direction , University Hospital of Verona , Verona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Girelli","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Internal Medicine , University of Verona , Verona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Lippi","sequence":"additional","affiliation":[{"name":"Service of Laboratory Medicine , University Hospital of Verona , Verona , Italy"},{"name":"Section of Clinical Biochemistry , University of Verona , Verona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,3,11]]},"reference":[{"key":"2023033111254788153_j_cclm-2020-0028_ref_001","doi-asserted-by":"crossref","unstructured":"Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, et al. Fourth universal definition of myocardial infarction (2018). Eur Heart J 2019;40:237\u201369.","DOI":"10.1093\/eurheartj\/ehy856"},{"key":"2023033111254788153_j_cclm-2020-0028_ref_002","doi-asserted-by":"crossref","unstructured":"Bolstad N, Warren DJ, Nustad K. Heterophilic antibody interference in immunometric assays. Best Pract Res Clin Endocrinol Metab 2013;27:647\u201361.","DOI":"10.1016\/j.beem.2013.05.011"},{"key":"2023033111254788153_j_cclm-2020-0028_ref_003","doi-asserted-by":"crossref","unstructured":"Lippi G, Aloe R, Meschi T, Borghi L, Cervellin G. Interference from heterophilic antibodies in troponin testing. Case report and systematic review of the literature. Clin Chim Acta 2013;426:79\u201384.","DOI":"10.1016\/j.cca.2013.09.004"},{"key":"2023033111254788153_j_cclm-2020-0028_ref_004","doi-asserted-by":"crossref","unstructured":"Kazmierczak SC, Catrou PG, Briley KP. Transient nature of interference effects from heterophile antibodies: examples ofinterference with cardiac marker measurements. Clin Chem Lab Med 2000;38:33\u20139.","DOI":"10.1515\/CCLM.2000.006"},{"key":"2023033111254788153_j_cclm-2020-0028_ref_005","doi-asserted-by":"crossref","unstructured":"White GH, Tideman PA. Heterophilic antibody interference with CARDIAC T Quantitative Rapid Assay. Clin Chem 2002;48:201\u20133.","DOI":"10.1093\/clinchem\/48.1.201"},{"key":"2023033111254788153_j_cclm-2020-0028_ref_006","doi-asserted-by":"crossref","unstructured":"Shayanfar N, Bestmann L, Schulthess G, Hersberger M. False-positive cardiac troponin T due to assay interference with heterophilic antibodies. Swiss Med Wkly 2008;138:470.","DOI":"10.4414\/smw.2008.12379"},{"key":"2023033111254788153_j_cclm-2020-0028_ref_007","doi-asserted-by":"crossref","unstructured":"Fortgens PH, Omar F. Cardiac troponin T quantitative assay failure as a result of antibody interference. Afr J Lab Med 2013;2:23.","DOI":"10.4102\/ajlm.v2i1.23"},{"key":"2023033111254788153_j_cclm-2020-0028_ref_008","doi-asserted-by":"crossref","unstructured":"Stavroulakis G, Papadopoulou M, Koutroulis G, Zouvelou V, Katsavochristos J, Georgiadis E, et al. Myasthenia gravis. A potential cause of false positively elevated troponin T? Case report and brief review. Int J Cardiol 2015;199:40\u20131.","DOI":"10.1016\/j.ijcard.2015.06.165"},{"key":"2023033111254788153_j_cclm-2020-0028_ref_009","doi-asserted-by":"crossref","unstructured":"Aliste-Fern\u00e1ndez M, Sole-Enrech G, Cano-Corres R, Teodoro-Marin S, Berlanga-Escalera E. Description of interference in the measurement of troponin T by a high-sensitivity method. Biochem Med (Zagreb) 2019;29:021001.","DOI":"10.11613\/BM.2018.021001"},{"key":"2023033111254788153_j_cclm-2020-0028_ref_010","doi-asserted-by":"crossref","unstructured":"Vilela EM, Bettencourt-Silva R, da Costa JT, Barbosa AR, Silva MP, Teixeira M, et al. Anti-cardiac troponin antibodies in clinical human disease: a systematic review. Ann Transl Med 2017;5:307.","DOI":"10.21037\/atm.2017.07.40"},{"key":"2023033111254788153_j_cclm-2020-0028_ref_011","doi-asserted-by":"crossref","unstructured":"Bjerner J, B\u00f8rmer OP, Nustad K. The war on heterophilic antibody interference. Clin Chem 2005;51:9\u201311.","DOI":"10.1373\/clinchem.2004.042994"},{"key":"2023033111254788153_j_cclm-2020-0028_ref_012","doi-asserted-by":"crossref","unstructured":"Lippi G, Cervellin G. La liaison fructueuse: laboratory and emergency medicine. Emerg Care J 2019;15:8344.","DOI":"10.4081\/ecj.2019.8344"},{"key":"2023033111254788153_j_cclm-2020-0028_ref_013","doi-asserted-by":"crossref","unstructured":"Zaninotto M, Clerico A, Casagranda I, Galvani M, Plebani M. A false positive case of cardiac troponin I: which diagnostic approach? Int J Cardiol 2014;177:e42\u20133.","DOI":"10.1016\/j.ijcard.2014.08.061"},{"key":"2023033111254788153_j_cclm-2020-0028_ref_014","doi-asserted-by":"crossref","unstructured":"Lippi G, Ardissino D, Aloe R, Cervellin G. A false positive case of cardiac troponin I identified with CK-MB reflex testing. Int J Cardiol 2014;176:e3\u20134.","DOI":"10.1016\/j.ijcard.2014.06.065"},{"key":"2023033111254788153_j_cclm-2020-0028_ref_015","doi-asserted-by":"crossref","unstructured":"Ismail AA. A radical approach is needed to eliminate interference from endogenous antibodies in immunoassays. Clin Chem 2005;51:25\u20136.","DOI":"10.1373\/clinchem.2004.042523"}],"container-title":["Clinical Chemistry and Laboratory Medicine (CCLM)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/cclm\/58\/10\/article-pe225.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/cclm-2020-0028\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/cclm-2020-0028\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T15:00:15Z","timestamp":1680274815000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/cclm-2020-0028\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,11]]},"references-count":15,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,2,7]]},"published-print":{"date-parts":[[2020,9,25]]}},"alternative-id":["10.1515\/cclm-2020-0028"],"URL":"https:\/\/doi.org\/10.1515\/cclm-2020-0028","relation":{},"ISSN":["1437-4331","1434-6621"],"issn-type":[{"value":"1437-4331","type":"electronic"},{"value":"1434-6621","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3,11]]}}}