{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T04:07:49Z","timestamp":1775275669360,"version":"3.50.1"},"reference-count":35,"publisher":"Walter de Gruyter GmbH","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_cclm-2020-0338_s_999\">\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Recently, there have been several studies on the clinical characteristics of patients with coronavirus disease 2019 (COVID-19); however, these studies have mainly been concentrated in Wuhan, China; the sample sizes of each article were different; and the reported clinical characteristics, especially blood biochemical indices, were quite different. This study aimed to summarize the blood biochemistry characteristics of COVID-19 patients by performing a systemic review and meta-analysis of published studies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2020-0338_s_998\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Comprehensive studies were screened from PubMed, Embase, and Cochrane Library through March 11, 2020. The inclusion criteria included studies investigating the biochemical indexes of patients with COVID-19. The statistical software R3.6.3 was used for meta-analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2020-0338_s_997\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Ten studies including 1745 COVID-19 patients met the inclusion criteria for our meta-analysis. Meta-analysis showed that 16% and 20% of patients with COVID-19 had alanine transaminase (ALT) and aspartate aminotransferase (AST) levels higher than the normal range, respectively. Thirty-four percent of patients showed albumin (ALB) levels lower than the normal range, and 6% of patients showed abnormal total bilirubin (TBil) levels. The levels of creatinine (CRE) were increased in 8% of patients. The creatine kinase (CK) level of 13% of patients exceeded the normal range, and 52% of patients had elevated lactate dehydrogenase (LDH) levels. In addition, six studies met the inclusion criteria for the systemic review evaluating the relevance between LDH levels and the severity of COVID-19, and all six studies showed a positive association between these two factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2020-0338_s_996\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Some patients with COVID-19 had different degrees of blood biochemical abnormalities, which might indicate multiple organ dysfunction. Some biochemical indexes, such as abnormal ALB and LDH, could reflect the severity of the disease to a certain extent. These blood biochemical indicators should be considered in the clinical management of the disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/cclm-2020-0338","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T13:04:32Z","timestamp":1594991072000},"page":"1172-1181","source":"Crossref","is-referenced-by-count":42,"title":["Blood biochemical characteristics of patients with coronavirus disease 2019 (COVID-19): a systemic review and meta-analysis"],"prefix":"10.1515","volume":"58","author":[{"given":"Xiaoling","family":"Deng","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Union Hospital, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , P.R. 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