{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:30:26Z","timestamp":1791851426595,"version":"4.3.4"},"reference-count":24,"publisher":"Walter de Gruyter GmbH","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_cclm-2020-0459_s_999_w2aab3b7c58b1b6b1aab1c16b1Aa\">\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Comprehensive information has been published on laboratory tests which may predict worse outcome in Asian populations with coronavirus disease 2019 (COVID-19). The aim of this study is to describe laboratory findings in a group of Italian COVID-19 patients in the area of Valcamonica, and correlate abnormalities with disease severity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2020-0459_s_998_w2aab3b7c58b1b6b1aab1c16b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The final study population consisted of 144 patients diagnosed with COVID-19 (70 who died during hospital stay and 74 who survived and could be discharged) between March 1 and 30, 2020, in Valcamonica Hospital. Demographical, clinical and laboratory data were collected upon hospital admission and were then correlated with outcome (i.e. in-hospital death vs. discharge).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2020-0459_s_997_w2aab3b7c58b1b6b1aab1c16b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Compared to patients who could be finally discharged, those who died during hospital stay displayed significantly higher values of serum glucose, aspartate aminotransferase (AST), creatine kinase (CK), lactate dehydrogenase (LDH), urea, creatinine, high-sensitivity cardiac troponin I (hscTnI), prothrombin time\/international normalized ratio (PT\/INR), activated partial thromboplastin time (APTT), D-dimer, C reactive protein (CRP), ferritin and leukocytes (especially neutrophils), whilst values of albumin, hemoglobin and lymphocytes were significantly decreased. In multiple regression analysis, LDH, CRP, neutrophils, lymphocytes, albumin, APTT and age remained significant predictors of in-hospital death. A regression model incorporating these variables explained 80% of overall variance of in-hospital death.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2020-0459_s_996_w2aab3b7c58b1b6b1aab1c16b4Aa\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The most important laboratory abnormalities described here in a subset of European COVID-19 patients residing in Valcamonica are highly predictive of in-hospital death and may be useful for guiding risk assessment and clinical decision-making.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/cclm-2020-0459","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T08:39:14Z","timestamp":1589186354000},"page":"1100-1105","source":"Crossref","is-referenced-by-count":87,"title":["Laboratory predictors of death from coronavirus disease 2019 (COVID-19) in the area of Valcamonica, Italy"],"prefix":"10.1515","volume":"58","author":[{"given":"Graziella","family":"Bonetti","sequence":"first","affiliation":[{"name":"Laboratory of Clinical Pathology , ASST-Valcamonica , Esine, Brescia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Manelli","sequence":"additional","affiliation":[{"name":"Emergency Department , ASST-Valcamonica , Esine, Brescia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Patroni","sequence":"additional","affiliation":[{"name":"Hospital Infections Committee , ASST-Valcamonica , Esine, Brescia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Bettinardi","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Pathology , ASST-Valcamonica , Esine, Brescia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Borrelli","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Pathology , ASST-Valcamonica , Esine, Brescia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Fiordalisi","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Pathology , ASST-Valcamonica , Esine, Brescia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Marino","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Pathology , ASST-Valcamonica , Esine, Brescia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Menolfi","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Pathology , ASST-Valcamonica , Esine, Brescia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Saggini","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Pathology , ASST-Valcamonica , Esine, Brescia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Volpi","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Pathology , ASST-Valcamonica , Esine, Brescia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano","family":"Anesi","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Pathology , Maggiore Hospital of Lodi , Lodi , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Lippi","sequence":"additional","affiliation":[{"name":"Section of Clinical Biochemistry , University of Verona , Verona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,4,28]]},"reference":[{"key":"2023033111141339576_j_cclm-2020-0459_ref_001_w2aab3b7c58b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Richman DD, Whitley RJ, Hayden FG, editors. Clinical virology, 4th ed. Washington: ASM Press, 2016.","DOI":"10.1128\/9781555819439"},{"key":"2023033111141339576_j_cclm-2020-0459_ref_002_w2aab3b7c58b1b6b1ab2b1b2Aa","doi-asserted-by":"crossref","unstructured":"Ksiazek TG, Erdman D, Goldsmith CS, Zaki SR, Peret T, Emery S, et al. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med 2003;348:1953\u201366.","DOI":"10.1056\/NEJMoa030781"},{"key":"2023033111141339576_j_cclm-2020-0459_ref_003_w2aab3b7c58b1b6b1ab2b1b3Aa","doi-asserted-by":"crossref","unstructured":"de Groot RJ, Baker SC, Baric RS, Brown CS, Drosten C, Enjuanes L, et al. Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group. J Virol 2013;87:7790\u201392.","DOI":"10.1128\/JVI.01244-13"},{"key":"2023033111141339576_j_cclm-2020-0459_ref_004_w2aab3b7c58b1b6b1ab2b1b4Aa","doi-asserted-by":"crossref","unstructured":"Chan JF, Yuan S, Kok KH, To KK, Chu H, Yang J, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to person transmission: a study of a family cluster. Lancet 2020;395:514\u201323.","DOI":"10.1016\/S0140-6736(20)30154-9"},{"key":"2023033111141339576_j_cclm-2020-0459_ref_005_w2aab3b7c58b1b6b1ab2b1b5Aa","doi-asserted-by":"crossref","unstructured":"Guan W-J, Ni Z-Y, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical characteristics of 2019 novel coronavirus infection in China. N Engl J Med 2020. doi: 10.1056\/NEJMoa2002032 [Epub ahead of print].","DOI":"10.1056\/NEJMoa2002032"},{"key":"2023033111141339576_j_cclm-2020-0459_ref_006_w2aab3b7c58b1b6b1ab2b1b6Aa","doi-asserted-by":"crossref","unstructured":"Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020;395:497\u2013506.","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"2023033111141339576_j_cclm-2020-0459_ref_007_w2aab3b7c58b1b6b1ab2b1b7Aa","unstructured":"World Health Organization. Coronavirus disease (COVID-19) outbreak situation https:\/\/www.who.int\/emergencies\/diseases\/novel-coronavirus-2019. Accessed: 5 April 2020."},{"key":"2023033111141339576_j_cclm-2020-0459_ref_008_w2aab3b7c58b1b6b1ab2b1b8Aa","doi-asserted-by":"crossref","unstructured":"Tang N, Li D, Wang X, Sun Z. Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost 2020;18:844\u20137.","DOI":"10.1111\/jth.14768"},{"key":"2023033111141339576_j_cclm-2020-0459_ref_009_w2aab3b7c58b1b6b1ab2b1b9Aa","doi-asserted-by":"crossref","unstructured":"Mattiuzzi C, Lippi G. Which lessons shall we learn from the 2019 novel coronavirus outbreak? Ann Transl Med 2020;8:48.","DOI":"10.21037\/atm.2020.02.06"},{"key":"2023033111141339576_j_cclm-2020-0459_ref_010_w2aab3b7c58b1b6b1ab2b1c10Aa","doi-asserted-by":"crossref","unstructured":"Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese center for disease control and prevention. J Am Med Assoc 2020. doi: 10.1001\/jama.2020.2648 [Epub ahead of print].","DOI":"10.1001\/jama.2020.2648"},{"key":"2023033111141339576_j_cclm-2020-0459_ref_011_w2aab3b7c58b1b6b1ab2b1c11Aa","doi-asserted-by":"crossref","unstructured":"Lippi G, Plebani M. The critical role of laboratory medicine during coronavirus disease 2019 (COVID-19) and other viral outbreaks. Clin Chem Lab Med 2020;58:1063\u20139.","DOI":"10.1515\/cclm-2020-0240"},{"key":"2023033111141339576_j_cclm-2020-0459_ref_012_w2aab3b7c58b1b6b1ab2b1c12Aa","doi-asserted-by":"crossref","unstructured":"Lippi G, Plebani M. The novel coronavirus (2019-nCoV) outbreak: think the unthinkable and be prepared to face the challenge. Diagnosis (Berl) 2020;7:79\u201381.","DOI":"10.1515\/dx-2020-0015"},{"key":"2023033111141339576_j_cclm-2020-0459_ref_013_w2aab3b7c58b1b6b1ab2b1c13Aa","doi-asserted-by":"crossref","unstructured":"Lippi G, Simundic AM, Plebani M. Potential preanalytical and analytical vulnerabilities in the laboratory diagnosis of coronavirus disease 2019 (COVID-19). Clin Chem Lab Med 2020;58:1070\u20136.","DOI":"10.1515\/cclm-2020-0285"},{"key":"2023033111141339576_j_cclm-2020-0459_ref_014_w2aab3b7c58b1b6b1ab2b1c14Aa","doi-asserted-by":"crossref","unstructured":"Lippi G, Plebani M. Laboratory abnormalities in patients with COVID-2019 infection. Clin Chem Lab Med 2020;58:1131\u20134.","DOI":"10.1515\/cclm-2020-0198"},{"key":"2023033111141339576_j_cclm-2020-0459_ref_015_w2aab3b7c58b1b6b1ab2b1c15Aa","doi-asserted-by":"crossref","unstructured":"Han H, Yang L, Liu R, Liu F, Wu K, Li J, et al. Prominent changes in blood coagulation of patients with SARS-CoV-2 infection. Clin Chem Lab Med 2020;58:1116\u201320.","DOI":"10.1515\/cclm-2020-0188"},{"key":"2023033111141339576_j_cclm-2020-0459_ref_016_w2aab3b7c58b1b6b1ab2b1c16Aa","doi-asserted-by":"crossref","unstructured":"Lippi G, Lavie CJ, Sanchis-Gomar F. Cardiac troponin I in patients with coronavirus disease 2019 (COVID-19): evidence from a meta-analysis. Prog Cardiovasc Dis 2020. pii: S0033-0620(20)30055-4. doi: 10.1016\/j.pcad.2020.03.001 [Epub ahead of print].","DOI":"10.1016\/j.pcad.2020.03.001"},{"key":"2023033111141339576_j_cclm-2020-0459_ref_017_w2aab3b7c58b1b6b1ab2b1c17Aa","doi-asserted-by":"crossref","unstructured":"Lippi G, Plebani M. Procalcitonin in patients with severe coronavirus disease 2019 (COVID-19): a meta-analysis. Clin Chim Acta 2020;505:190\u20131. doi: 10.1016\/j.cca.2020.03.004. Epub 2020 Mar 4.","DOI":"10.1016\/j.cca.2020.03.004"},{"key":"2023033111141339576_j_cclm-2020-0459_ref_018_w2aab3b7c58b1b6b1ab2b1c18Aa","doi-asserted-by":"crossref","unstructured":"Henry BM, Santos de Oliveira MH, Benoit S, Plebani M, Lippi G. Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis. Clin Chem Lab Med 2020;58:1021\u20138.","DOI":"10.1515\/cclm-2020-0369"},{"key":"2023033111141339576_j_cclm-2020-0459_ref_019_w2aab3b7c58b1b6b1ab2b1c19Aa","doi-asserted-by":"crossref","unstructured":"Xu H, Zhong L, Deng J, Peng J, Dan H, Zeng X, et al. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. Int J Oral Sci 2020;12:8.","DOI":"10.1038\/s41368-020-0074-x"},{"key":"2023033111141339576_j_cclm-2020-0459_ref_020_w2aab3b7c58b1b6b1ab2b1c20Aa","doi-asserted-by":"crossref","unstructured":"Tan L, Wang Q, Zhang D, Ding J, Huang Q, Tang YQ, et al. Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study. Signal Transduct Target Ther 2020;5:33.","DOI":"10.1038\/s41392-020-0148-4"},{"key":"2023033111141339576_j_cclm-2020-0459_ref_021_w2aab3b7c58b1b6b1ab2b1c21Aa","doi-asserted-by":"crossref","unstructured":"Cervellin G, Schuetz P, Lippi G. Toward a holistic approach for diagnosing sepsis in the emergency department. Adv Clin Chem 2019;92:201\u201316.","DOI":"10.1016\/bs.acc.2019.04.004"},{"key":"2023033111141339576_j_cclm-2020-0459_ref_022_w2aab3b7c58b1b6b1ab2b1c22Aa","doi-asserted-by":"crossref","unstructured":"Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020;395:1054\u201362.","DOI":"10.1016\/S0140-6736(20)30566-3"},{"key":"2023033111141339576_j_cclm-2020-0459_ref_023_w2aab3b7c58b1b6b1ab2b1c23Aa","doi-asserted-by":"crossref","unstructured":"Chiang CH, Shih JF, Su WJ, Perng RP. Eight-month prospective study of 14 patients with hospital-acquired severe acute respiratory syndrome. Mayo Clin Proc 2004;79:1372\u20139.","DOI":"10.4065\/79.11.1372"},{"key":"2023033111141339576_j_cclm-2020-0459_ref_024_w2aab3b7c58b1b6b1ab2b1c24Aa","doi-asserted-by":"crossref","unstructured":"Favaloro EJ, Lippi G. Recommendations for minimal laboratory testing panels in patients with COVID-19: potential for prognostic monitoring. Semin Thromb Hemost 2020. doi: 10.1055\/s-0040-1709498 [Epub ahead of print].","DOI":"10.1055\/s-0040-1709498"}],"container-title":["Clinical Chemistry and Laboratory Medicine (CCLM)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/cclm\/58\/7\/article-p1100.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/cclm-2020-0459\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/cclm-2020-0459\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T14:08:36Z","timestamp":1680271716000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/cclm-2020-0459\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,28]]},"references-count":24,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,5,12]]},"published-print":{"date-parts":[[2020,6,25]]}},"alternative-id":["10.1515\/cclm-2020-0459"],"URL":"https:\/\/doi.org\/10.1515\/cclm-2020-0459","relation":{},"ISSN":["1437-4331","1434-6621"],"issn-type":[{"value":"1437-4331","type":"electronic"},{"value":"1434-6621","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4,28]]}}}