{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T15:43:39Z","timestamp":1782315819432,"version":"3.54.5"},"reference-count":72,"publisher":"Walter de Gruyter GmbH","issue":"6","funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["GNT1139340"],"award-info":[{"award-number":["GNT1139340"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Victorian Government Operational Infrastructure Support Program"},{"name":"NHMRC Early Career Fellowship","award":["GNT1123030"],"award-info":[{"award-number":["GNT1123030"]}]},{"DOI":"10.13039\/501100001782","name":"University of Melbourne","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001782","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Health and Medical Research Council Clinical Career Development Fellowship","award":["1053889"],"award-info":[{"award-number":["1053889"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Despite a century of research, bilirubin metabolism and the transport mechanisms responsible for homeostasis of bilirubin in serum remain controversial. Emerging evidence on the hepatic membrane transporters and inherited disorders of bilirubin metabolism have contributed to a greater understanding of the various steps involved in bilirubin homeostasis and its associated excretory pathways. We discuss these recent research findings on hepatic membrane transporters and evaluate their significance on the newborn bilirubin metabolism and excretion. New insights gained speculate that a proportion of conjugated bilirubin is excreted via the renal system, as an alternative to the intestinal excretion, even in normal physiological jaundice with no associated pathological concerns. Finally, this paper discusses the clinical relevance of targeting the altered renal excretory pathway, as bilirubin in urine may hold diagnostic importance in screening for neonatal jaundice.<\/jats:p>","DOI":"10.1515\/cclm-2020-1759","type":"journal-article","created":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T06:21:21Z","timestamp":1611382881000},"page":"1025-1033","source":"Crossref","is-referenced-by-count":26,"title":["Mechanism of bilirubin elimination in urine: insights and prospects for neonatal jaundice"],"prefix":"10.1515","volume":"59","author":[{"given":"Mercy","family":"Thomas","sequence":"first","affiliation":[{"name":"New Vaccines , Murdoch Children\u2019s Research Institute , Melbourne , Victoria , Australia"},{"name":"Department of Paediatrics , University of Melbourne , Melbourne , Australia"},{"name":"Newborn Research Centre , Royal Women\u2019s Hospital , Melbourne , Victoria , Australia"},{"name":"Department of Nursing , Royal Children\u2019s Hospital , Melbourne , Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winita","family":"Hardikar","sequence":"additional","affiliation":[{"name":"Department of Paediatrics , University of Melbourne , Melbourne , Australia"},{"name":"Department of Gastroenterology , Royal Children\u2019s Hospital , Melbourne , Victoria , Australia"},{"name":"Clinical Sciences, Murdoch Children\u2019s Research Institute , Melbourne , Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7823-8797","authenticated-orcid":false,"given":"Ronda F.","family":"Greaves","sequence":"additional","affiliation":[{"name":"Department of Paediatrics , University of Melbourne , Melbourne , Australia"},{"name":"School of Health and Biomedical Sciences , RMIT University , Melbourne , Victoria , Australia"},{"name":"Victorian Clinical Genetics Services , Melbourne , Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Tingay","sequence":"additional","affiliation":[{"name":"Department of Paediatrics , University of Melbourne , Melbourne , Australia"},{"name":"Newborn Research Centre , Royal Women\u2019s Hospital , Melbourne , Victoria , Australia"},{"name":"Neonatal Research , Murdoch Children\u2019s Research Institute , Melbourne , Victoria , Australia"},{"name":"Department of Neonatology , Royal Children\u2019s Hospital , Melbourne , Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tze Ping","family":"Loh","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine , National University Hospital , Singapore , Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Ignjatovic","sequence":"additional","affiliation":[{"name":"Department of Paediatrics , University of Melbourne , Melbourne , Australia"},{"name":"Haematology Research , Murdoch Children\u2019s Research Institute , Melbourne , Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Newall","sequence":"additional","affiliation":[{"name":"Department of Paediatrics , University of Melbourne , Melbourne , Australia"},{"name":"Department of Nursing , Royal Children\u2019s Hospital , Melbourne , Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anushi E.","family":"Rajapaksa","sequence":"additional","affiliation":[{"name":"New Vaccines , Murdoch Children\u2019s Research Institute , Melbourne , Victoria , Australia"},{"name":"Department of Paediatrics , University of Melbourne , Melbourne , Australia"},{"name":"Newborn Research Centre , Royal Women\u2019s Hospital , Melbourne , Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,1,15]]},"reference":[{"key":"2021082201593420039_j_cclm-2020-1759_ref_001","unstructured":"Cashore, W. 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