{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T20:23:35Z","timestamp":1793996615218,"version":"4.8.0"},"reference-count":39,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_cclm-2020-1885_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Thyroid biomarkers are fundamental for the diagnosis of thyroid disorders and for the monitoring and treatment of patients with these diseases. The knowledge of biological variation (BV) is important to define analytical performance specifications (APS) and reference change values (RCV). The aim of this study was to deliver BV estimates for thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), thyroglobulin (TG), and calcitonin (CT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2020-1885_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Analyses were performed on serum samples obtained from the European Biological Variation Study population (91 healthy individuals from six European laboratories; 21\u201369 years) on the Roche Cobas e801 at the San Raffaele Hospital (Milan, Italy). All samples from each individual were evaluated in duplicate within a single run. The BV estimates with 95% CIs were obtained by CV-ANOVA, after analysis of variance homogeneity and outliers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2020-1885_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The within-subject (CV\n                      <jats:sub>\n                        <jats:italic>I<\/jats:italic>\n                      <\/jats:sub>\n                      ) BV estimates were for TSH 17.7%, FT3 5.0%, FT4 4.8%, TG 10.3, and CT 13.0%, all significantly lower than those reported in the literature. No significant differences were observed for BV estimates between men and women.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2020-1885_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The availability of updated, in the case of CT not previously published, BV estimates for thyroid markers based on the large scale EuBIVAS study allows for refined APS and associated RCV applicable in the diagnosis and management of thyroid and related diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/cclm-2020-1885","type":"journal-article","created":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T06:27:25Z","timestamp":1613024845000},"page":"523-532","source":"Crossref","is-referenced-by-count":48,"title":["European Biological Variation Study (EuBIVAS): within- and between-subject biological variation estimates for serum thyroid biomarkers based on weekly samplings from 91 healthy participants"],"prefix":"10.1515","volume":"60","author":[{"given":"Michela","family":"Bottani","sequence":"first","affiliation":[{"name":"IRCCS Istituto Ortopedico Galeazzi, Laboratory of Experimental Biochemistry & Molecular Biology , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aasne K.","family":"Aarsand","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Pharmacology , Haukeland University Hospital , Bergen , Norway"},{"name":"Norwegian Organization for Quality Improvement of Laboratory Examinations (Noklus), Haraldsplass Deaconess Hospital , Bergen , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Banfi","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Ortopedico Galeazzi, Laboratory of Experimental Biochemistry & Molecular Biology , Milan , Italy"},{"name":"Vita-Salute San Raffaele University , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Locatelli","sequence":"additional","affiliation":[{"name":"Laboratory Medicine, IRCCS San Raffaele Scientific Institute , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdurrahman","family":"Co\u015fkun","sequence":"additional","affiliation":[{"name":"School of Medicine, Acibadem Mehmet Ali Ayd\u0131nlar University , Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"D\u00edaz-Garz\u00f3n","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Paz , Madrid , Spain"},{"name":"Quality Analytical Commission of Spanish Society of Clinical Chemistry (SEQC) , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Fernandez-Calle","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Paz , Madrid , Spain"},{"name":"Quality Analytical Commission of Spanish Society of Clinical Chemistry (SEQC) , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sverre","family":"Sandberg","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Pharmacology , Haukeland University Hospital , Bergen , Norway"},{"name":"Norwegian Organization for Quality Improvement of Laboratory Examinations (Noklus), Haraldsplass Deaconess Hospital , Bergen , Norway"},{"name":"Department of Global Public Health and Primary Care , University of Bergen , Bergen , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0958-5354","authenticated-orcid":false,"given":"Ferruccio","family":"Ceriotti","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Fondazione IRCCS Ca\u2019 Granda, Ospedale Maggiore Policlinico , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Carobene","sequence":"additional","affiliation":[{"name":"Laboratory Medicine, IRCCS San Raffaele Scientific Institute , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,2,9]]},"reference":[{"key":"2022033122424033783_j_cclm-2020-1885_ref_001","doi-asserted-by":"crossref","unstructured":"Soh, SB, Aw, TC. 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