{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:09:27Z","timestamp":1792026567200,"version":"4.4.0"},"reference-count":30,"publisher":"Walter de Gruyter GmbH","issue":"9","funder":[{"name":"I Colori della Vita Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_cclm-2021-0278_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The early detection of preterm infants (PI) at risk for intraventricular hemorrhage (IVH) and neurological sequelae still constitutes an unsolved issue. We aimed at validating the role of S100B protein in the early diagnosis and prognosis of IVH in PI by means of cerebral ultrasound (CUS) and magnetic resonance imaging (MRI) today considered standard of care procedures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2021-0278_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted an observational case-control study in 216 PI of whom 36 with IVH and 180 controls. Standard clinical, laboratory, radiological monitoring procedures and S100B urine measurement were performed at four time-points (first void, 24, 48, 96\u00a0h) after birth. Cerebral MRI was performed at 40\u201342\u00a0weeks of corrected gestational age.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2021-0278_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Elevated (p&lt;0.001, for all) S100B levels were observed in the IVH group at all monitoring time-point particularly at first void when standard monitoring procedures were still silent or unavailable. S100B measured at first void correlated (p&lt;0.001) with the grade of hemorrhage by means of CUS and with the site and extension of neurological lesion (p&lt;0.001, for all) as assessed by MRI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2021-0278_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The present results showing a correlation among S100B and CUS and MRI offer additional support to the inclusion of the protein in clinical daily management of cases at risk for IVH and adverse neurological outcome. The findings open the way to further investigations in PI aimed at validating new neurobiomarkers by means of S100B.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/cclm-2021-0278","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T01:57:06Z","timestamp":1621389426000},"page":"1527-1534","source":"Crossref","is-referenced-by-count":13,"title":["S100B protein, cerebral ultrasound and magnetic resonance imaging patterns in brain injured preterm infants"],"prefix":"10.1515","volume":"59","author":[{"given":"Giorgia","family":"Gasparroni","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit , G. d\u2019Annunzio University , Chieti , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Graziosi","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit , G. d\u2019Annunzio University , Chieti , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iliana","family":"Bersani","sequence":"additional","affiliation":[{"name":"Department of Neonatology , Neonatal Intensive Care Unit, Bambino Ges\u00f9; Children\u2019s Hospital , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Caulo","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences , University \u201cG. d\u2019Annunzio\u201d , Chieti , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bashir","family":"Moataza","sequence":"additional","affiliation":[{"name":"Department of Neonatology , Cairo University , Cairo , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Aboulgar","sequence":"additional","affiliation":[{"name":"Department of Neonatology , Cairo University , Cairo , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hala","family":"Mufeed","sequence":"additional","affiliation":[{"name":"Department of Neonatology , Cairo University , Cairo , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman","family":"Iskander","sequence":"additional","affiliation":[{"name":"Department of Neonatology , Cairo University , Cairo , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Kornacka","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Intensive Care of Neonate , Warsaw University , Warsaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darek","family":"Gruzfeld","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Intensive Care of Neonate , Warsaw University , Warsaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Dotta","sequence":"additional","affiliation":[{"name":"Department of Neonatology , Neonatal Intensive Care Unit, Bambino Ges\u00f9; Children\u2019s Hospital , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Immacolata","family":"Savarese","sequence":"additional","affiliation":[{"name":"Department of Neonatology , Neonatal Intensive Care Unit, Bambino Ges\u00f9; Children\u2019s Hospital , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Chukhlantseva","sequence":"additional","affiliation":[{"name":"Department of Neonatology , Neonatal Intensive Care Unit, Bambino Ges\u00f9; Children\u2019s Hospital , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia Gabriella","family":"Tina","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal and Neonatal Health , G. Garibaldi Hospital , Catania , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Nigro","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal and Neonatal Health , G. Garibaldi Hospital , Catania , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Livolti","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , Catania University , Catania , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Galvano","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , Catania University , Catania , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Di Battista","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit , G. d\u2019Annunzio University , Chieti , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebe","family":"D\u2019Adamo","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit , G. d\u2019Annunzio University , Chieti , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adele Patrizia","family":"Primavera","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit , G. d\u2019Annunzio University , Chieti , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Lapergola","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit , G. d\u2019Annunzio University , Chieti , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Conte","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit , G. d\u2019Annunzio University , Chieti , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Salomone","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit , G. d\u2019Annunzio University , Chieti , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marika","family":"Perrotta","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit , G. d\u2019Annunzio University , Chieti , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Panichi","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit , G. d\u2019Annunzio University , Chieti , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Levantini","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit , G. d\u2019Annunzio University , Chieti , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Catenaro","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , G. d\u2019Annunzio University , Chieti , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Strozzi","sequence":"additional","affiliation":[{"name":"Department of Maternal, Fetal and Neonatal Medicine, ASO SS Antonio, Biagio and C. Arrigo , Alessandria , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Maconi","sequence":"additional","affiliation":[{"name":"Department of Maternal, Fetal and Neonatal Medicine, ASO SS Antonio, Biagio and C. Arrigo , Alessandria , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Centini","sequence":"additional","affiliation":[{"name":"Department of Maternal, Fetal and Neonatal Medicine, ASO SS Antonio, Biagio and C. Arrigo , Alessandria , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Chiarelli","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , G. d\u2019Annunzio University , Chieti , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"D\u2019Antonio","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Centre for Fetal Care and High Risk Pregnancy, University G. d\u2019Annunzio , Chieti , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo A.W.","family":"Gavilanes","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Neonatology , Maastricht University , Maastricht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Gazzolo","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit , G. d\u2019Annunzio University , Chieti , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,5,19]]},"reference":[{"key":"2023033111540836312_j_cclm-2021-0278_ref_001","doi-asserted-by":"crossref","unstructured":"Rubens, CE, Sadovsky, Y, Muglia, L, Gravett, MG, Lackritz, E, Gravett, C. Prevention of preterm birth: harnessing science to address the global epidemic. Sci Transl Med 2014;6:262sr5. https:\/\/doi.org\/10.1126\/scitranslmed.3009871.","DOI":"10.1126\/scitranslmed.3009871"},{"key":"2023033111540836312_j_cclm-2021-0278_ref_002","doi-asserted-by":"crossref","unstructured":"Costeloe, KL, Hennessy, EM, Haider, S, Stacey, F, Marlow, N, Draper, ES. Short term outcomes after extreme preterm birth in England: comparison of two birth cohorts in 1995 and 2006 (the EPICure studies). BMJ 2012;345:e7976. https:\/\/doi.org\/10.1136\/bmj.e7976.","DOI":"10.1136\/bmj.e7976"},{"key":"2023033111540836312_j_cclm-2021-0278_ref_003","doi-asserted-by":"crossref","unstructured":"Glass, HC, Costarino, AT, Stayer, SA, Brett, CM, Cladis, F, Davis, PJ. Outcomes for extremely premature infants. Anesth Analg 2015;120:1337\u201351. https:\/\/doi.org\/10.1213\/ane.0000000000000705.","DOI":"10.1213\/ANE.0000000000000705"},{"key":"2023033111540836312_j_cclm-2021-0278_ref_004","doi-asserted-by":"crossref","unstructured":"Szpecht, D, Szymankiewicz, M, Nowak, I, Gadzinowski, J. Intraventricular hemorrhage in neonates born before 32\u00a0weeks of gestation\u2014retrospective analysis of risk factors. Child\u2019s Nerv Syst 2016;32:1399\u2013404. https:\/\/doi.org\/10.1007\/s00381-016-3127-x.","DOI":"10.1007\/s00381-016-3127-x"},{"key":"2023033111540836312_j_cclm-2021-0278_ref_005","doi-asserted-by":"crossref","unstructured":"Leijser, LM, de Vries, LS. Preterm brain injury: germinal matrix\u2013intraventricular hemorrhage and post-hemorrhagic ventricular dilatation. In: Handbook of clinical neurology 2019:162:173\u201399.","DOI":"10.1016\/B978-0-444-64029-1.00008-4"},{"key":"2023033111540836312_j_cclm-2021-0278_ref_006","doi-asserted-by":"crossref","unstructured":"Serpero, LD, Bellissima, V, Colivicchi, M, Sabatini, M, Frigiola, A, Ricotti, A, et al.. Next generation biomarkers for brain injury. J Matern Fetal Neonatal Med 2013;26(2 Suppl):44\u20139. https:\/\/doi.org\/10.3109\/14767058.2013.829688.","DOI":"10.3109\/14767058.2013.829688"},{"key":"2023033111540836312_j_cclm-2021-0278_ref_007","doi-asserted-by":"crossref","unstructured":"Bersani, I, Pluchinotta, F, Dotta, A, Savarese, I, Campi, F, Auriti, C, et al.. Early predictors of perinatal brain damage: the role of neurobiomarkers. Clin Chem Lab Med 2020;58:471\u201386. https:\/\/doi.org\/10.1515\/cclm-2019-0725.","DOI":"10.1515\/cclm-2019-0725"},{"key":"2023033111540836312_j_cclm-2021-0278_ref_008","doi-asserted-by":"crossref","unstructured":"Alshweki, A, P\u00e9rez-Mu\u00f1uzuri, A, L\u00f3pez-Su\u00e1rez, O, Ba\u00f1a, A, Couce, ML. Relevance of urinary S100B protein levels as a short-term prognostic biomarker in asphyxiated infants treated with hypothermia. Medicine 2017;96:e8453. https:\/\/doi.org\/10.1097\/md.0000000000008453.","DOI":"10.1097\/MD.0000000000008453"},{"key":"2023033111540836312_j_cclm-2021-0278_ref_009","doi-asserted-by":"crossref","unstructured":"Gazzolo, D, Florio, P, Ciotti, S, Marinoni, E, Di Iorio, R, Bruschettini, M, et al.. S100B protein in urine of preterm newborns with ominous outcome. Pediatr Res 2005;58:1170\u20134. https:\/\/doi.org\/10.1203\/01.pdr.0000185131.22985.30.","DOI":"10.1203\/01.pdr.0000185131.22985.30"},{"key":"2023033111540836312_j_cclm-2021-0278_ref_010","doi-asserted-by":"crossref","unstructured":"Campbell, S, Thoms, A. Ultrasound measurement of the fetal head to abdomen circumference ratio in the assessment of growth retardation. BJOG An Int J Obstet Gynaecol 1977;84:165\u201374. https:\/\/doi.org\/10.1111\/j.1471-0528.1977.tb12550.x.","DOI":"10.1111\/j.1471-0528.1977.tb12550.x"},{"key":"2023033111540836312_j_cclm-2021-0278_ref_011","doi-asserted-by":"crossref","unstructured":"Papile, LA, Burstein, J, Burstein, R, Koffler, H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr 1978;92:529\u201334. https:\/\/doi.org\/10.1016\/s0022-3476(78)80282-0.","DOI":"10.1016\/S0022-3476(78)80282-0"},{"key":"2023033111540836312_j_cclm-2021-0278_ref_012","doi-asserted-by":"crossref","unstructured":"Kidokoro, H, Neil, JJ, Inder, TE. New MR imaging assessment tool to define brain abnormalities in very preterm infants at term. Am J Neuroradiol 2013;34:2208\u201314. https:\/\/doi.org\/10.3174\/ajnr.a3521.","DOI":"10.3174\/ajnr.A3521"},{"key":"2023033111540836312_j_cclm-2021-0278_ref_013","unstructured":"Prechtl, HFR. Assessment methods for the newborn infant, a critical evaluation. In: Stratton, P, editor. Psychobiology of the human newborn. Chichester: Wiley; 1982:21\u201352 pp."},{"key":"2023033111540836312_j_cclm-2021-0278_ref_014","doi-asserted-by":"crossref","unstructured":"Jurgens-van der Zee, AD, Bierman-van Eendenburg, MEC, Fidler, VJ, Olinga, AA, Visch, JH, Touwen, BCL, et al.. Preterm birth, growth retardation and acidemia in relation to neurological abnormality of the newborn. Early Hum Dev 1979;3:141\u201354. https:\/\/doi.org\/10.1016\/0378-3782(79)90003-3.","DOI":"10.1016\/0378-3782(79)90003-3"},{"key":"2023033111540836312_j_cclm-2021-0278_ref_015","doi-asserted-by":"crossref","unstructured":"Jobe, AH, Bancalari, E. Bronchopulmonary dysplasia. Am J Respir Crit Care Med 2001;163:1723\u20139. https:\/\/doi.org\/10.1164\/ajrccm.163.7.2011060.","DOI":"10.1164\/ajrccm.163.7.2011060"},{"key":"2023033111540836312_j_cclm-2021-0278_ref_016","unstructured":"Agarwal, K, Jalali, S. Classification of retinopathy of prematurity: from then till now. Community Eye Health 2018;31:S4\u20137."},{"key":"2023033111540836312_j_cclm-2021-0278_ref_017","doi-asserted-by":"crossref","unstructured":"Baudier, J, Glasser, N, Haglid, K, Gerard, D. Purification, characterization and ion binding properties of human brain S100b protein. Biochim Biophys Acta Protein Struct Mol Enzymol 1984;790:164\u201373. https:\/\/doi.org\/10.1016\/0167-4838(84)90220-6.","DOI":"10.1016\/0167-4838(84)90220-6"},{"key":"2023033111540836312_j_cclm-2021-0278_ref_018","doi-asserted-by":"crossref","unstructured":"McCrea, HJ, Ment, LR. The diagnosis, management, and postnatal prevention of intraventricular hemorrhage in the preterm neonate. Clin Perinatol 2008;35:777\u201392. https:\/\/doi.org\/10.1016\/j.clp.2008.07.014.","DOI":"10.1016\/j.clp.2008.07.014"},{"key":"2023033111540836312_j_cclm-2021-0278_ref_019","doi-asserted-by":"crossref","unstructured":"Whitelaw, A. Intraventricular haemorrhage and posthaemorrhagic hydrocephalus: pathogenesis, prevention and future interventions. Semin Neonatol 2001;6:135\u201346. https:\/\/doi.org\/10.1053\/siny.2001.0047.","DOI":"10.1053\/siny.2001.0047"},{"key":"2023033111540836312_j_cclm-2021-0278_ref_020","unstructured":"Volpe, JJ. Intrachranial hemorrhage: germinal matrix-intraventricular hemorrhage of premature infant. In: Neurology of the newborn, 5th ed. Philadelphia: Saunders; 2018, vol 11:403\u201363 pp."},{"key":"2023033111540836312_j_cclm-2021-0278_ref_021","doi-asserted-by":"crossref","unstructured":"Gazzolo, D, Bruschettini, M, Lituania, M, Serra, G, Bonacci, W, Michetti, F. Increased urinary S100B protein as an early indicator of intraventricular hemorrhage in preterm infants: correlation with the grade of hemorrhage. Clin Chem 2001;47:1836\u20138. https:\/\/doi.org\/10.1093\/clinchem\/47.10.1836.","DOI":"10.1093\/clinchem\/47.10.1836"},{"key":"2023033111540836312_j_cclm-2021-0278_ref_022","doi-asserted-by":"crossref","unstructured":"Sannia, A, Zimmermann, LJI, Gavilanes, AWD, Vles, HJ, Serpero, LD, Frulio, R, et al.. S100B protein maternal and fetal bloodstreams gradient in healthy and small for gestational age pregnancies. Clin Chim Acta 2011;412:1337\u201340. https:\/\/doi.org\/10.1016\/j.cca.2011.03.034.","DOI":"10.1016\/j.cca.2011.03.034"},{"key":"2023033111540836312_j_cclm-2021-0278_ref_023","doi-asserted-by":"crossref","unstructured":"Florio, P, Marinoni, E, Di Iorio, R, Bashir, M, Ciotti, S, Sacchi, R, et al.. Urinary S100B protein concentrations are increased in intrauterine growth-retarded newborns. Pediatrics 2006;118:e747\u201354. https:\/\/doi.org\/10.1542\/peds.2005-2875.","DOI":"10.1542\/peds.2005-2875"},{"key":"2023033111540836312_j_cclm-2021-0278_ref_024","doi-asserted-by":"crossref","unstructured":"Gazzolo, D, Marinoni, E, Di Iorio, R, Lituania, M, Bruschettini, PL, Michetti, F. Circulating S100\u03b2 protein is increased in intrauterine growth-retarded fetuses. Pediatr Res 2002;51:215\u20139. https:\/\/doi.org\/10.1203\/00006450-200202000-00015.","DOI":"10.1203\/00006450-200202000-00015"},{"key":"2023033111540836312_j_cclm-2021-0278_ref_025","doi-asserted-by":"crossref","unstructured":"Gazzolo, D, Di Iorio, R, Marinoni, E, Masetti, P, Serra, G, Giovannini, L, et al.. S100B protein is increased in asphyxiated term infants developing intraventricular hemorrhage. Crit Care Med 2002;30:1356\u201360. https:\/\/doi.org\/10.1097\/00003246-200206000-00037.","DOI":"10.1097\/00003246-200206000-00037"},{"key":"2023033111540836312_j_cclm-2021-0278_ref_026","doi-asserted-by":"crossref","unstructured":"Michetti, F, D\u2019Ambrosi, N, Toesca, A, Puglisi, MA, Serrano, A, Marchese, E, et al.. The S100B story: from biomarker to active factor in neural injury. J Neurochem 2019;148:168\u201387. https:\/\/doi.org\/10.1111\/jnc.14574.","DOI":"10.1111\/jnc.14574"},{"key":"2023033111540836312_j_cclm-2021-0278_ref_027","doi-asserted-by":"crossref","unstructured":"Giussani, DA, Thakor, AS, Frulio, R, Gazzolo, D. Acute hypoxia increases S100\u03b2 protein in association with blood flow redistribution away from peripheral circulations in fetal sheep. Pediatr Res 2005;58:179\u201384. https:\/\/doi.org\/10.1203\/01.pdr.0000169999.66157.c0.","DOI":"10.1203\/01.PDR.0000169999.66157.C0"},{"key":"2023033111540836312_j_cclm-2021-0278_ref_028","doi-asserted-by":"crossref","unstructured":"Garnier, Y, Frigiola, A, Li Volti, G, Florio, P, Frulio, R, Berger, R, et al.. Increased maternal\/fetal blood S100B levels following systemic\u00a0endotoxin administration and periventricular white matter injury in preterm fetal sheep. Reprod Sci 2009;16:758\u201366. https:\/\/doi.org\/10.1177\/1933719109335801.","DOI":"10.1177\/1933719109335801"},{"key":"2023033111540836312_j_cclm-2021-0278_ref_029","doi-asserted-by":"crossref","unstructured":"Gazzolo, D, Pluchinotta, F, Bashir, M, Aboulgar, H, Said, HM, Iman, I, et al.. Neurological abnormalities in full-term asphyxiated newborns and salivary S100B testing: the \u201cCooperative Multitask against Brain Injury of Neonates\u201d (CoMBINe) international study. PloS One 2015;10:e0115194. https:\/\/doi.org\/10.1371\/journal.pone.0115194.","DOI":"10.1371\/journal.pone.0115194"},{"key":"2023033111540836312_j_cclm-2021-0278_ref_030","doi-asserted-by":"crossref","unstructured":"Gazzolo, D, Lituania, M, Bruschettini, M, Ciotti, S, Sacchi, R, Serra, G, et al.. S100B protein levels in saliva: correlation with gestational age in normal term and preterm newborns. Clin Biochem 2005;38:229\u201333. https:\/\/doi.org\/10.1016\/j.clinbiochem.2004.12.006.","DOI":"10.1016\/j.clinbiochem.2004.12.006"}],"container-title":["Clinical Chemistry and Laboratory Medicine (CCLM)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/cclm-2021-0278\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/cclm-2021-0278\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T16:01:51Z","timestamp":1680278511000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/cclm-2021-0278\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,19]]},"references-count":30,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021,5,19]]},"published-print":{"date-parts":[[2021,8,26]]}},"alternative-id":["10.1515\/cclm-2021-0278"],"URL":"https:\/\/doi.org\/10.1515\/cclm-2021-0278","relation":{},"ISSN":["1434-6621","1437-4331"],"issn-type":[{"value":"1434-6621","type":"print"},{"value":"1437-4331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,19]]}}}