{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:47:47Z","timestamp":1760986067109},"reference-count":10,"publisher":"Walter de Gruyter GmbH","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_cclm-2021-0483_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Accurate detection of SARS-CoV-2 RNA is essential to stopping the spread of SARS-CoV-2. The aim of this study was to evaluate the performance of the recently introduced MassARRAY<jats:sup>\u00ae<\/jats:sup> SARS-CoV-2 Panel and to compare it to the cobas<jats:sup>\u00ae<\/jats:sup> SARS-CoV-2 Test.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2021-0483_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The MassARRAY<jats:sup>\u00ae<\/jats:sup> SARS-CoV-2 Panel consists of five assays targeting different sequences of the SARS-CoV-2 genome. Accuracy was determined using national and international proficiency panels including 27 samples. For clinical evaluation, 101 residual clinical samples were analyzed and results compared. Samples had been tested for SARS-CoV-2 RNA with the cobas<jats:sup>\u00ae<\/jats:sup> SARS-CoV-2 Test.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2021-0483_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>When accuracy was tested with the MassARRAY<jats:sup>\u00ae<\/jats:sup> SARS-CoV-2 Panel, 25 of 27 (92.6%) samples revealed correct results. When clinical samples were analyzed with the MassARRAY<jats:sup>\u00ae<\/jats:sup> SARS-CoV-2 Panel and compared to the cobas<jats:sup>\u00ae<\/jats:sup> SARS-CoV-2 Test, 100 samples showed concordant results. One sample was found to be inconclusive with the MassARRAY<jats:sup>\u00ae<\/jats:sup> SARS-CoV-2 Panel. When time-to-results were compared, the new assay showed longer total and hands-on times.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2021-0483_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The MassARRAY<jats:sup>\u00ae<\/jats:sup> SARS-CoV-2 Panel showed a good performance and proved to be suitable for use in the routine diagnostic laboratory. Especially during phases of shortage of reagents and\/or disposables, the new test system appears as beneficial alternative to standard assays used for detection of SARS-CoV-2 RNA.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/cclm-2021-0483","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T17:49:23Z","timestamp":1628876963000},"page":"1998-2002","source":"Crossref","is-referenced-by-count":2,"title":["Alternative detection of SARS-CoV-2 RNA by a new assay based on mass spectrometry"],"prefix":"10.1515","volume":"59","author":[{"given":"Evelyn","family":"Stelzl","sequence":"first","affiliation":[{"name":"Research Unit Molecular Diagnostics , Diagnostic and Research Center for Molecular Biomedicine, Medical University of Graz , Graz , Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald H.","family":"Kessler","sequence":"additional","affiliation":[{"name":"Research Unit Molecular Diagnostics , Diagnostic and Research Center for Molecular Biomedicine, Medical University of Graz , Graz , Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans G.","family":"Mustafa","sequence":"additional","affiliation":[{"name":"Medilab\u00a0\u2013 Medizinisch-Chemisches Laboratorium Dr. Mustafa, Dr. Richter OG , Salzburg , Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria E.","family":"Mustafa","sequence":"additional","affiliation":[{"name":"Medilab\u00a0\u2013 Medizinisch-Chemisches Laboratorium Dr. Mustafa, Dr. Richter OG , Salzburg , Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte I.","family":"Santner","sequence":"additional","affiliation":[{"name":"Research Unit Molecular Diagnostics , Diagnostic and Research Center for Molecular Biomedicine, Medical University of Graz , Graz , Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Seier","sequence":"additional","affiliation":[{"name":"Central Laboratory , Klinikum Wels-Grieskirchen GmbH , Wels , Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"La Torre","sequence":"additional","affiliation":[{"name":"Central Laboratory , Klinikum Wels-Grieskirchen GmbH , Wels , Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander C.","family":"Haushofer","sequence":"additional","affiliation":[{"name":"Central Laboratory , Klinikum Wels-Grieskirchen GmbH , Wels , Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,8,12]]},"reference":[{"key":"2023033112143572277_j_cclm-2021-0483_ref_001","doi-asserted-by":"crossref","unstructured":"Xiu, L, Zhang, C, Wu, Z, Peng, J. 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