{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T09:07:43Z","timestamp":1772788063412,"version":"3.50.1"},"reference-count":19,"publisher":"Walter de Gruyter GmbH","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_cclm-2021-0569_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The detection of SARS-CoV-2 in infected people is a key tool to help in controlling COVID-19 pandemic. Like rapid antigenic tests, automated antigen tests, that present the advantage of a higher throughput flow, may be of interest. The LIAISON<jats:sup>\u00ae<\/jats:sup> SARS-CoV-2 Ag test was evaluated for the quantification of SARS-CoV-2 nucleocapsid antigen in nasopharyngeal swabs by comparison to RT-PCR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2021-0569_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The study involved 378 nasopharyngeal samples (UTM<jats:sup>\u00ae<\/jats:sup> and FLOQSwab\u2122, Copan Diagnostics), including 46 swabs positive for SARS-CoV-2 by RT-PCR. These samples came from asymptomatic (n=99, 26.2%) or symptomatic people (n=279, 73.8%), at different times from symptom onset. The samples were analyzed on LIAISON<jats:sup>\u00ae<\/jats:sup> XL.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2021-0569_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The overall specificity was 99.4% (CI95% [98.6\u2013100]). The negative predictive value reached 100% in asymptomatic people. Among the 46 positive samples, the overall sensitivity was 84.8% (CI95% [74.4\u201395.2]), reached 91.9% (CI95% [83.1\u2013100]) in the first fourth days after symptoms onset and was 100% for Cq values\u00a0\u226425. Antigen was not detected in samples with Cq values &gt;25. Similar results were observed on nasopharyngeal swabs coming from patients infected with the 20I\/501Y.V1 variant or the 20H\/501Y.V2 variant.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2021-0569_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>According to technical performances, the LIAISON<jats:sup>\u00ae<\/jats:sup> SARS-CoV-2 Ag test may be a useful tool for COVID-19 diagnosis, especially during the first four days of symptoms.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/cclm-2021-0569","type":"journal-article","created":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T18:40:21Z","timestamp":1627756821000},"page":"2003-2009","source":"Crossref","is-referenced-by-count":13,"title":["Performance evaluation of an automated SARS-CoV-2 Ag test for the diagnosis of COVID-19 infection on nasopharyngeal swabs"],"prefix":"10.1515","volume":"59","author":[{"given":"C\u00e9dric","family":"Hartard","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Lorraine, CNRS, LCPME , Nancy , France"},{"name":"Laboratoire de Virologie, CHRU de Nancy Brabois , Vandoeuvre-l\u00e8s-Nancy , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sibel","family":"Berger","sequence":"additional","affiliation":[{"name":"Plateforme de G\u00e9nomique Microbienne, CHRU de Nancy Brabois , Vandoeuvre-l\u00e8s-Nancy , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Josse","sequence":"additional","affiliation":[{"name":"Plateforme de G\u00e9nomique Microbienne, CHRU de Nancy Brabois , Vandoeuvre-l\u00e8s-Nancy , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyne","family":"Schvoerer","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, CNRS, LCPME , Nancy , France"},{"name":"Laboratoire de Virologie, CHRU de Nancy Brabois , Vandoeuvre-l\u00e8s-Nancy , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Jeulin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, CNRS, LCPME , Nancy , France"},{"name":"Laboratoire de Virologie, CHRU de Nancy Brabois , Vandoeuvre-l\u00e8s-Nancy , France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,7,30]]},"reference":[{"key":"2023033112143561847_j_cclm-2021-0569_ref_001","doi-asserted-by":"crossref","unstructured":"Zhou, P, Lou, YX, Wang, XG, Hu, B, Zhang, L, Zhang, W, et al.. 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