{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T21:09:24Z","timestamp":1782508164719,"version":"3.54.5"},"reference-count":33,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Coronavirus disease 2019 (COVID-19) is an infectious respiratory condition sustained by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which manifests prevalently as mild to moderate respiratory tract infection. Nevertheless, in a number of cases the clinical course may deteriorate, with onset of end organ injury, systemic dysfunction, thrombosis and ischemia. Given the clinical picture, baseline assessment and serial monitoring of blood lactate concentration may be conceivably useful in\u00a0COVID-19. We hence performed a systematic literature review to explore the possible association between increased blood lactate levels, disease severity and mortality in COVID-19 patients, including comparison of lactate values between COVID-19 and non-COVID-19 patients. We carried out an electronic search in Medline and Scopus, using the keywords \u201cCOVID-19\u201d OR \u201cSARS-CoV-2\u201d AND \u201clactate\u201d OR \u201clactic acid\u201d OR \u201chyperlactatemia\u201d, between 2019 and present time (i.e. October 10, 2021), which allowed to identify 19\u00a0studies, totalling 6,459 patients. Overall, we found that COVID-19 patients with worse outcome tend to display higher lactate values than those with better outcome, although most COVID-19 patients in the studies included in our analysis did not have sustained baseline hyperlactatemia. Substantially elevated lactate values were neither consistently present in all COVID-19 patients who developed unfavourable clinical outcomes. These findings suggest that blood lactate monitoring upon admission and throughout hospitalization may be useful for early identification of higher risk of unfavourable COVID-19 illness progression, though therapeutic decisions based on using conventional hyperlactatemia cut-off values (i.e.,\u00a02.0\u00a0mmol\/L) upon first evaluation may be inappropriate in patients with SARS-CoV-2 infection.<\/jats:p>","DOI":"10.1515\/cclm-2021-1115","type":"journal-article","created":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T18:45:35Z","timestamp":1638470735000},"page":"332-337","source":"Crossref","is-referenced-by-count":55,"title":["Blood lactate concentration in COVID-19: a systematic literature review"],"prefix":"10.1515","volume":"60","author":[{"given":"Giovanni","family":"Carpen\u00e8","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Section of Clinical Biochemistry , Biomedicine and Movement Sciences, University of Verona , Verona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diletta","family":"Onorato","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Section of Clinical Biochemistry , Biomedicine and Movement Sciences, University of Verona , Verona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Nocini","sequence":"additional","affiliation":[{"name":"Department of Surgery, Dentistry, Paediatrics and Gynaecology , University of Verona , Verona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianmarco","family":"Fortunato","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Section of Clinical Biochemistry , Biomedicine and Movement Sciences, University of Verona , Verona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5216-8695","authenticated-orcid":false,"given":"John G.","family":"Rizk","sequence":"additional","affiliation":[{"name":"Arizona State University, Edson College , Phoenix , AZ , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon M.","family":"Henry","sequence":"additional","affiliation":[{"name":"Cardiac Intensive Care Unit, The Heart Institute, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati , OH , USA"},{"name":"Host-Pathogen Interactions & Population Health Programs, Texas Biomedical Research Institute , San Antonio , TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9523-9054","authenticated-orcid":false,"given":"Giuseppe","family":"Lippi","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Section of Clinical Biochemistry , Biomedicine and Movement Sciences, University of Verona , Verona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,12,2]]},"reference":[{"key":"2022022617414396056_j_cclm-2021-1115_ref_001","doi-asserted-by":"crossref","unstructured":"Lippi, G, Sanchis-Gomar, F, Henry, BM. 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