{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:41:28Z","timestamp":1765546888680,"version":"3.37.3"},"reference-count":36,"publisher":"Walter de Gruyter GmbH","issue":"5","funder":[{"DOI":"10.13039\/100016545","name":"Roche Diagnostics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016545","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_cclm-2021-1276_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Rapid antigen tests (RAT) can provide valuable information on the presence or absence SARS-CoV-2 within 15\u00a0min without the need of a laboratory. The analytical and diagnostic characteristics of available RATs has led to the question whether they can safely distinguish between infectious and non-infectious patients in an acute care setting.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2021-1276_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Three nasopharyngeal swabs for the analysis by RAT, reverse transcriptase real time polymerase chain reaction (RT-qPCR), and a cell culture based infection assay were collected from 67 patients that presented to the emergency department of the University Hospital of Graz (Austria). The first swab was used for on-site RAT testing in the emergency department using the Roche SARS-CoV-2 RAT. The second swab was sent to the central laboratory of the hospital for RT-qPCR with two independent methods (Cepheid Xpert<jats:sup>\u00ae<\/jats:sup> Xpress SARS-CoV-2 assay and Roche Cobas SARS-CoV-2 Test) and repeat RAT testing using the same commercial test. With the third swab a cell culture-based infection assay was performed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2021-1276_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The RATs performed from independent samples showed substantial agreement (Cohen\u2019s-kappa: 0.73, p&lt;0.001). All patients with a positive RAT had positive RT-qPCR with cycle threshold (ct) values &lt;25. Fifteen out of 55 RAT-negative samples were RT-qPCR positive with ct values between 25 and 40. The inoculation of cell cultures with RT-qPCR negative swabs and RT-qPCR positive swabs with ct values &gt;25 did not induce cytopathic effects that were related to SARS-CoV-2. The infection assays from four RAT-negative patients showed cytopathic effects that were induced by other pathogens.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2021-1276_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The SARS-CoV-2 RAT from Roche Diagnostics is a valuable tool for managing symptomatic patients. RAT-negative patients may be regarded as non-contagious.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/cclm-2021-1276","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T10:20:15Z","timestamp":1646734815000},"page":"778-785","source":"Crossref","is-referenced-by-count":11,"title":["Identification of contagious SARS-CoV-2 infected individuals by Roche\u2019s Rapid Antigen Test"],"prefix":"10.1515","volume":"60","author":[{"given":"Harald H.","family":"Kessler","sequence":"first","affiliation":[{"name":"Molecular Diagnostics Laboratory, Diagnostic and Research Institute of Hygiene,Microbiology, and Environmental Medicine, Medical University of Graz , Graz , Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Pr\u00fcller","sequence":"additional","affiliation":[{"name":"Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz , Graz , Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melina","family":"Hardt","sequence":"additional","affiliation":[{"name":"Diagnostic- and Research Center for Molecular Biomedicine, Institute of Pathology, Medical University of Graz , Graz , Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyn","family":"Stelzl","sequence":"additional","affiliation":[{"name":"Molecular Diagnostics Laboratory, Diagnostic and Research Institute of Hygiene,Microbiology, and Environmental Medicine, Medical University of Graz , Graz , Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"F\u00f6derl-H\u00f6benreich","sequence":"additional","affiliation":[{"name":"Diagnostic- and Research Center for Molecular Biomedicine, Institute of Pathology, Medical University of Graz , Graz , Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Pailer","sequence":"additional","affiliation":[{"name":"Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz , Graz , Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Lueger","sequence":"additional","affiliation":[{"name":"Division of Emergency Medicine, Department of Internal Medicine , Medical University of Graz , Graz , Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Kreuzer","sequence":"additional","affiliation":[{"name":"Division of Emergency Medicine, Department of Internal Medicine , Medical University of Graz , Graz , Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Zatloukal","sequence":"additional","affiliation":[{"name":"Diagnostic- and Research Center for Molecular Biomedicine, Institute of Pathology, Medical University of Graz , Graz , Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Molecular Diagnostics Laboratory, Diagnostic and Research Institute of Hygiene,Microbiology, and Environmental Medicine, Medical University of Graz , Graz , Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,3,7]]},"reference":[{"key":"2023033111480978922_j_cclm-2021-1276_ref_001","doi-asserted-by":"crossref","unstructured":"Zhu, Z, Lian, X, Su, X, Wu, W, Marraro, GA, Zeng, Y. From SARS and MERS to COVID-19: a brief summary and comparison of severe acute respiratory infections caused by three highly pathogenic human coronaviruses. Respir Res 2020;21:224. https:\/\/doi.org\/10.1186\/s12931-020-01479-w.","DOI":"10.1186\/s12931-020-01479-w"},{"key":"2023033111480978922_j_cclm-2021-1276_ref_002","doi-asserted-by":"crossref","unstructured":"da Silva, SJR, da Silva, CTA, Guarines, KM, Mendes, RPG, Pardee, K, Kohl, A. Clinical and laboratory diagnosis of SARS-CoV-2, the virus causing COVID-19. ACS Infect Dis 2020;6:2319\u201336. https:\/\/doi.org\/10.1021\/acsinfecdis.0c00274.","DOI":"10.1021\/acsinfecdis.0c00274"},{"key":"2023033111480978922_j_cclm-2021-1276_ref_003","doi-asserted-by":"crossref","unstructured":"Sule, WF, Oluwayelu, DO. Real-time RT-PCR for COVID-19 diagnosis: challenges and prospects. Pan Afr Med J 2020;35:121. https:\/\/doi.org\/10.11604\/pamj.supp.2020.35.24258.","DOI":"10.11604\/pamj.supp.2020.35.2.24258"},{"key":"2023033111480978922_j_cclm-2021-1276_ref_004","doi-asserted-by":"crossref","unstructured":"Ward, S, Lindsley, A, Courter, J, Assa\u2019ad, A. Clinical testing for COVID-19. J Allergy Clin Immunol 2020;146:23\u201334. https:\/\/doi.org\/10.1016\/j.jaci.2020.05.012.","DOI":"10.1016\/j.jaci.2020.05.012"},{"key":"2023033111480978922_j_cclm-2021-1276_ref_005","doi-asserted-by":"crossref","unstructured":"Loeffelholz, MJ, Alland, D, Butler-Wu, SM, Pandey, U, Perno, CF, Nava, A. Multicenter evaluation of the Cepheid Xpert Xpress SARS-CoV-2 test. J Clin Microbiol 2020;58:e00926\u201320. https:\/\/doi.org\/10.1128\/JCM.00926-20.","DOI":"10.1128\/JCM.00926-20"},{"key":"2023033111480978922_j_cclm-2021-1276_ref_006","doi-asserted-by":"crossref","unstructured":"Wolters, F, Gr\u00fcnberg, M, Huber, M, Kessler, HH, Pr\u00fcller, F, Saleh, L, et al.. European multicenter evaluation of Xpert\u00ae Xpress SARS-CoV-2\/Flu\/RSV test. J Med Virol 2021;93:5798\u2013804. https:\/\/doi.org\/10.1002\/jmv.27111.","DOI":"10.1002\/jmv.27111"},{"key":"2023033111480978922_j_cclm-2021-1276_ref_007","doi-asserted-by":"crossref","unstructured":"Toptan, T, Eckermann, L, Pfeiffer, AE, Hoehl, S, Ciesek, S, Drosten, C. Evaluation of a SARS-CoV-2 rapid antigen test: potential to help reduce community spread? J Clin Virol 2021;135:104713. https:\/\/doi.org\/10.1016\/j.jcv.2020.104713.","DOI":"10.1016\/j.jcv.2020.104713"},{"key":"2023033111480978922_j_cclm-2021-1276_ref_008","doi-asserted-by":"crossref","unstructured":"Khandker, SS, Nik Hashim, NHH, Deris, ZZ, Shueb, RH, Islam, MA. Diagnostic accuracy of rapid antigen test kits for detecting SARS-CoV-2: a systematic review and meta-analysis of 17,171 suspected COVID-19 patients. J Clin Med 2021;10:3493. https:\/\/doi.org\/10.3390\/jcm10163493.","DOI":"10.3390\/jcm10163493"},{"key":"2023033111480978922_j_cclm-2021-1276_ref_009","doi-asserted-by":"crossref","unstructured":"Mitchell, SL, Orris, S, Freeman, T, Freeman, MC, Adam, M, Axe, M, et al.. Performance of SARS-CoV-2 antigen testing in symptomatic and asymptomatic adults: a single-center evaluation. BMC Infect Dis 2021;21:1071. https:\/\/doi.org\/10.1186\/s12879-021-06716-1.","DOI":"10.1186\/s12879-021-06716-1"},{"key":"2023033111480978922_j_cclm-2021-1276_ref_010","doi-asserted-by":"crossref","unstructured":"Rao, SN, Manissero, D, Steele, VR, Pareja, J. A systematic review of the clinical utility of cycle threshold values in the context of COVID-19. Infect Dis Ther 2020;9:573\u201386. https:\/\/doi.org\/10.1007\/s40121-020-00324-3.","DOI":"10.1007\/s40121-020-00324-3"},{"key":"2023033111480978922_j_cclm-2021-1276_ref_011","doi-asserted-by":"crossref","unstructured":"Pickering, S, Batra, R, Merrick, B, Snell, LB, Nebbia, G, Douthwaite, S. Comparative performance of SARS-CoV-2 lateral flow antigen tests and association with detection of infectious virus in clinical specimens: a single-centre laboratory evaluation study. Lancet Microbe 2021;2:e461\u201371. https:\/\/doi.org\/10.1016\/s2666-5247(21)00143-9.","DOI":"10.1016\/S2666-5247(21)00143-9"},{"key":"2023033111480978922_j_cclm-2021-1276_ref_012","doi-asserted-by":"crossref","unstructured":"La Scola, B, Le Bideau, M, Andreani, J, Hoang, VT, Grimaldier, C, Colson, P, et al.. Viral RNA load as determined by cell culture as a management tool for discharge of SARS-CoV-2 patients from infectious disease wards. Eur J Clin Microbiol Infect Dis 2020;39:1059\u201361. https:\/\/doi.org\/10.1007\/s10096-020-03913-9.","DOI":"10.1007\/s10096-020-03913-9"},{"key":"2023033111480978922_j_cclm-2021-1276_ref_013","doi-asserted-by":"crossref","unstructured":"Ford, L, Lee, C, Pray, IW, Cole, D, Bigouette, JP, Abedi, GR, et al.. Epidemiologic characteristics associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen-based test results, real-time reverse transcription polymerase chain reaction (rRT-PCR) cycle threshold values, subgenomic RNA, and viral culture results from University testing. Clin Infect Dis 2021;73:e1348\u201355. https:\/\/doi.org\/10.1093\/cid\/ciab303.","DOI":"10.1093\/cid\/ciab303"},{"key":"2023033111480978922_j_cclm-2021-1276_ref_014","doi-asserted-by":"crossref","unstructured":"Kr\u00fcttgen, A, Cornelissen, CG, Dreher, M, Hornef, MW, Im\u00f6hl, M, Kleines, M. Comparison of the SARS-CoV-2 Rapid antigen test to the real star Sars-CoV-2 RT PCR kit. J Virol Methods 2021;288:114024. https:\/\/doi.org\/10.1016\/j.jviromet.2020.114024.","DOI":"10.1016\/j.jviromet.2020.114024"},{"key":"2023033111480978922_j_cclm-2021-1276_ref_015","doi-asserted-by":"crossref","unstructured":"Scohy, A, Anantharajah, A, Bod\u00e9us, M, Kabamba-Mukadi, B, Verroken, A, Rodriguez-Villalobos, H. Low performance of rapid antigen detection test as frontline testing for COVID-19 diagnosis. J Clin Virol 2020;129:104455. https:\/\/doi.org\/10.1016\/j.jcv.2020.104455.","DOI":"10.1016\/j.jcv.2020.104455"},{"key":"2023033111480978922_j_cclm-2021-1276_ref_016","doi-asserted-by":"crossref","unstructured":"Halfon, P, Penaranda, G, Khiri, H, Garcia, V, Drouet, H, Philibert, P, et al.. An optimized stepwise algorithm combining rapid antigen and RT-qPCR for screening of COVID-19 patients. PLoS One 2021;16:e0257817. https:\/\/doi.org\/10.1371\/journal.pone.0257817.","DOI":"10.1371\/journal.pone.0257817"},{"key":"2023033111480978922_j_cclm-2021-1276_ref_017","unstructured":"Veronesi, L, Colucci, ME, Pasquarella, C, Caruso, L, Mohieldin Mahgoub Ibrahim, M, Zoni, R, et al.. Virological surveillance of SARS-CoV-2 in an Italian northern area: comparison of Real Time RT PCR cycle threshold (Ct) values in three epidemic periods. Acta Biomed 2020;91:19\u201321. https:\/\/doi.org\/10.23750\/abm.v91i9-S.10138."},{"key":"2023033111480978922_j_cclm-2021-1276_ref_018","unstructured":"Reno, C, Lenzi, J, Golinelli, D, Gori, D, Signorelli, C, Kraemer, J. SARS-CoV-2\/COVID-19 testing: the tower of Babel. Acta Biomed 2020;91:e2020144. https:\/\/doi.org\/10.23750\/abm.v91i4.10911."},{"key":"2023033111480978922_j_cclm-2021-1276_ref_019","doi-asserted-by":"crossref","unstructured":"Lanser, L, Bellmann-Weiler, R, \u00d6ttl, K-W, Huber, L, Griesmacher, A, Theurl, I, et al.. Evaluating the clinical utility and sensitivity of SARS-CoV-2 antigen testing in relation to RT-PCR Ct values. Infection 2021;49:555\u20137. https:\/\/doi.org\/10.1007\/s15010-020-01542-0.","DOI":"10.1007\/s15010-020-01542-0"},{"key":"2023033111480978922_j_cclm-2021-1276_ref_020","doi-asserted-by":"crossref","unstructured":"Porte, L, Legarraga, P, Vollrath, V, Aguilera, X, Munita, JM, Araos, R, et al.. Evaluation of a novel antigen-based rapid detection test for the diagnosis of SARS-CoV-2 in respiratory samples. Int J Infect Dis 2020;99:328\u201333. https:\/\/doi.org\/10.1016\/j.ijid.2020.05.098.","DOI":"10.1016\/j.ijid.2020.05.098"},{"key":"2023033111480978922_j_cclm-2021-1276_ref_021","doi-asserted-by":"crossref","unstructured":"Buchta, C, G\u00f6rzer, I, Chiba, P, Camp, JV, Holzmann, H, Puchhammer-St\u00f6ckl, E. Variability of cycle threshold values in an external quality assessment scheme for detection of the SARS-CoV-2 virus genome by RT-PCR. Clin Chem Lab Med 2021;59:987\u201394. https:\/\/doi.org\/10.1515\/cclm-2020-1602.","DOI":"10.1515\/cclm-2020-1602"},{"key":"2023033111480978922_j_cclm-2021-1276_ref_022","doi-asserted-by":"crossref","unstructured":"Salvatore, PP, Dawson, P, Wadhwa, A, Rabold, EM, Buono, S, Dietrich, EA, et al.. Epidemiological correlates of polymerase chain reaction cycle threshold values in the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Clin Infect Dis 2021;72:e761\u20137. https:\/\/doi.org\/10.1093\/cid\/ciaa1469.","DOI":"10.1093\/cid\/ciaa1469"},{"key":"2023033111480978922_j_cclm-2021-1276_ref_023","doi-asserted-by":"crossref","unstructured":"Alexandersen, S, Chamings, A, Bhatta, TR. SARS-CoV-2 genomic and subgenomic RNAs in diagnostic samples are not an indicator of active replication. Nat Commun 2020;11:6059. https:\/\/doi.org\/10.1038\/s41467-020-19883-7.","DOI":"10.1038\/s41467-020-19883-7"},{"key":"2023033111480978922_j_cclm-2021-1276_ref_024","doi-asserted-by":"crossref","unstructured":"W\u00f6lfel, R, Corman, VM, Guggemos, W, Seilmaier, M, Zange, S, M\u00fcller, MA, et al.. Virological assessment of hospitalized patients with COVID-2019. Nature 2020;581:465\u20139. https:\/\/doi.org\/10.1038\/s41586-020-2196-x.","DOI":"10.1038\/s41586-020-2196-x"},{"key":"2023033111480978922_j_cclm-2021-1276_ref_025","doi-asserted-by":"crossref","unstructured":"Str\u00f6mer, A, Rose, R, Sch\u00e4fer, M, Sch\u00f6n, F, Vollersen, A, Lorentz, T, et al.. Performance of a point-of-care test for the rapid detection of SARS-CoV-2 antigen. Microorganisms 2020;9:E58.","DOI":"10.3390\/microorganisms9010058"},{"key":"2023033111480978922_j_cclm-2021-1276_ref_026","doi-asserted-by":"crossref","unstructured":"Wikramaratna, PS, Paton, RS, Ghafari, M, Louren\u00e7o, J. Estimating the false-negative test probability of SARS-CoV-2 by RT-PCR. Euro Surveill 2020;25:2000568. https:\/\/doi.org\/10.2807\/1560-7917.ES.2020.25.50.2000568.","DOI":"10.2807\/1560-7917.ES.2020.25.50.2000568"},{"key":"2023033111480978922_j_cclm-2021-1276_ref_027","doi-asserted-by":"crossref","unstructured":"Pardo Lledias, J, Ayarza, L, Gonz\u00e1lez-Garc\u00eda, P, Salm\u00f3n Gonz\u00e1lez, Z, Calvo Montes, J, Gozalo Marguello, M. Repetition of microbiological tests in suspect of SARS-CoV-2 infection: utility of a score based on clinical probability. Rev Espa\u00f1ola Quimioter 2020;33:410\u20134. https:\/\/doi.org\/10.37201\/req\/080.2020.","DOI":"10.37201\/req\/080.2020"},{"key":"2023033111480978922_j_cclm-2021-1276_ref_028","doi-asserted-by":"crossref","unstructured":"Lee, RA, Herigon, JC, Benedetti, A, Pollock, NR, Denkinger, CM. Performance of Saliva, oropharyngeal swabs, and nasal swabs for SARS-CoV-2 molecular detection: a systematic review and meta-analysis. J Clin Microbiol 2021;59:e02881\u201320. https:\/\/doi.org\/10.1128\/JCM.02881-20.","DOI":"10.1128\/JCM.02881-20"},{"key":"2023033111480978922_j_cclm-2021-1276_ref_029","doi-asserted-by":"crossref","unstructured":"Kucirka, LM, Lauer, SA, Laeyendecker, O, Boon, D, Lessler, J. Variation in false-negative rate of reverse transcriptase polymerase chain reaction-based SARS-CoV-2 tests by time since exposure. Ann Intern Med 2020;173:262\u20137. https:\/\/doi.org\/10.7326\/m20-1495.","DOI":"10.7326\/M20-1495"},{"key":"2023033111480978922_j_cclm-2021-1276_ref_030","doi-asserted-by":"crossref","unstructured":"Callahan, C, Lee, RA, Lee, GR, Zulauf, K, Kirby, JE, Arnaout, R. Nasal swab performance by collection timing, procedure, and method of transport for patients with SARS-CoV-2. J Clin Microbiol 2021;59:e0056921. https:\/\/doi.org\/10.1128\/JCM.00569-21.","DOI":"10.1128\/JCM.00569-21"},{"key":"2023033111480978922_j_cclm-2021-1276_ref_031","doi-asserted-by":"crossref","unstructured":"Mallett, S, Allen, AJ, Graziadio, S, Taylor, SA, Sakai, NS, Green, K, et al.. At what times during infection is SARS-CoV-2 detectable and no longer detectable using RT-PCR-based tests? A systematic review of individual participant data. BMC Med 2020;18:346. https:\/\/doi.org\/10.1186\/s12916-020-01810-8.","DOI":"10.1186\/s12916-020-01810-8"},{"key":"2023033111480978922_j_cclm-2021-1276_ref_032","doi-asserted-by":"crossref","unstructured":"Nagura-Ikeda, M, Imai, K, Tabata, S, Miyoshi, K, Murahara, N, Mizuno, T, et al.. Clinical evaluation of self-collected Saliva by quantitative reverse transcription-PCR (RT-qPCR), direct RT-qPCR, reverse transcription-loop-mediated isothermal amplification, and a rapid antigen test to diagnose COVID-19. J Clin Microbiol 2020;58:e01438\u201320. https:\/\/doi.org\/10.1128\/JCM.01438-20.","DOI":"10.1128\/JCM.01438-20"},{"key":"2023033111480978922_j_cclm-2021-1276_ref_033","doi-asserted-by":"crossref","unstructured":"Zhou, Y, Wu, Y, Ding, L, Huang, X, Xiong, Y. Point-of-care COVID-19 diagnostics powered by lateral flow assay. Trends Anal Chem 2021;145:116452. https:\/\/doi.org\/10.1016\/j.trac.2021.116452.","DOI":"10.1016\/j.trac.2021.116452"},{"key":"2023033111480978922_j_cclm-2021-1276_ref_034","doi-asserted-by":"crossref","unstructured":"Chaimayo, C, Kaewnaphan, B, Tanlieng, N, Athipanyasilp, N, Sirijatuphat, R, Chayakulkeeree, M, et al.. Rapid SARS-CoV-2 antigen detection assay in comparison with real-time RT-PCR assay for laboratory diagnosis of COVID-19 in Thailand. Virol J 2020;17:177. https:\/\/doi.org\/10.1186\/s12985-020-01452-5.","DOI":"10.1186\/s12985-020-01452-5"},{"key":"2023033111480978922_j_cclm-2021-1276_ref_035","doi-asserted-by":"crossref","unstructured":"Mertens, P, De Vos, N, Martiny, D, Jassoy, C, Mirazimi, A, Cuypers, L. Development and potential Usefulness of the COVID-19 Ag respi-Strip diagnostic assay in a pandemic context. Front Med (Lausanne) 2020;7:225. https:\/\/doi.org\/10.3389\/fmed.2020.00225.","DOI":"10.3389\/fmed.2020.00225"},{"key":"2023033111480978922_j_cclm-2021-1276_ref_036","doi-asserted-by":"crossref","unstructured":"Osterman, A, Iglhaut, M, Lehner, A, Sp\u00e4th, P, Stern, M, Autenrieth, H, et al.. Comparison of four commercial, automated antigen tests to detect SARS-CoV-2 variants of concern. Med Microbiol Immunol 2021;210:263\u201375. https:\/\/doi.org\/10.1007\/s00430-021-00719-0.","DOI":"10.1007\/s00430-021-00719-0"}],"container-title":["Clinical Chemistry and Laboratory Medicine (CCLM)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/cclm-2021-1276\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/cclm-2021-1276\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T15:43:27Z","timestamp":1680277407000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/cclm-2021-1276\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,7]]},"references-count":36,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,2,15]]},"published-print":{"date-parts":[[2022,4,26]]}},"alternative-id":["10.1515\/cclm-2021-1276"],"URL":"https:\/\/doi.org\/10.1515\/cclm-2021-1276","relation":{},"ISSN":["1434-6621","1437-4331"],"issn-type":[{"type":"print","value":"1434-6621"},{"type":"electronic","value":"1437-4331"}],"subject":[],"published":{"date-parts":[[2022,3,7]]}}}