{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:55:00Z","timestamp":1778637300352,"version":"3.51.4"},"reference-count":21,"publisher":"Walter de Gruyter GmbH","issue":"7","license":[{"start":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T00:00:00Z","timestamp":1649980800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_cclm-2021-1320_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Spectrophotometric absorption curve analysis of cerebrospinal fluid (CSF) for oxyhaemoglobin and bilirubin is necessary to accurately diagnose subarachnoid haemorrhage (SAH) in patients with typical symptoms but with negative findings on X-ray examinations. In this study, we evaluated the performance of two methods for interpreting absorption curves; one method from the United Kingdom National External Quality Assessment Service (UK-NEQAS) and the other from the national quality assurance programme in Sweden (Equalis).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2021-1320_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Consecutive absorbance curves (n=336) were interpreted with two different methods, and their performance was compared to the diagnosis as stated in the patient records.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2021-1320_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The UK-NEQAS method displayed equal sensitivity to the Equalis method, but the specificity of the UK-NEQAS method was significantly higher than the Equalis method resulting in fewer false positive results. For UK-NEQAS, a positive predictive value (PPV) of 84.6% and a negative predictive value (NPV) of 99.7% were observed, whereas the Equalis method had a PPV of 27.5% and an NPV of 99.7%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2021-1320_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The semi-automated method based on the guidelines from UK-NEQAS provides an efficient and correct interpretation of absorbance curves with short turn-around times. We propose using this method for the routine interpretation of CSF spectrophotometric curves.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/cclm-2021-1320","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T06:12:09Z","timestamp":1649916729000},"page":"1053-1057","source":"Crossref","is-referenced-by-count":3,"title":["Detection of subarachnoid haemorrhage with spectrophotometry of cerebrospinal fluid\u00a0\u2013 a comparison of two methods"],"prefix":"10.1515","volume":"60","author":[{"given":"Marcus","family":"Clarin","sequence":"first","affiliation":[{"name":"Clinical Chemistry and Transfusion Medicine , V\u00e4xj\u00f6 Central Hospital , V\u00e4xj\u00f6 , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"Petersson","sequence":"additional","affiliation":[{"name":"Clinical Chemistry and Transfusion Medicine , V\u00e4xj\u00f6 Central Hospital , V\u00e4xj\u00f6 , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry , Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg , Gothenburg , Sweden"},{"name":"Clinical Neurochemistry Laboratory , Sahlgrenska University Hospital , M\u00f6lndal , Sweden"},{"name":"Department of Neurodegenerative Disease , UCL Institute of Neurology , London , UK"},{"name":"UK Dementia Research Institute at UCL , London , UK"},{"name":"Hong Kong Center for Neurodegenerative Diseases , Hong Kong , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Ekblom","sequence":"additional","affiliation":[{"name":"Department of Research and Development , Region Kronoberg, V\u00e4xj\u00f6 , Sweden"},{"name":"Department of Medical Biosciences , Clinical Chemistry, Ume\u00e5 University , Ume\u00e5 , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,4,15]]},"reference":[{"key":"2023033113231541078_j_cclm-2021-1320_ref_001","doi-asserted-by":"crossref","unstructured":"Chao, CY, Florkowski, CM, Fink, JN, Southby, SJ, George, PM. 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