{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T02:09:16Z","timestamp":1778638156494,"version":"3.51.4"},"reference-count":17,"publisher":"Walter de Gruyter GmbH","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_cclm-2022-0576_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Aldosterone and renin determinations play an important role in the etiological diagnosis of secondary hypertension. The analytical performances of new aldosterone and renin immunoassays on the Lumipulse G600II<jats:sup>\u00ae<\/jats:sup> system (Fujierbio) were investigated and compared with those of the iSYS<jats:sup>\u00ae<\/jats:sup> system (IDS) on patients concerned by medical investigations in a context of suspected or proven Primary aldosteronism.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2022-0576_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>By using the Lumipulse<jats:sup>\u00ae<\/jats:sup> G Aldosterone and Renin assays we performed imprecision study, linearity and method comparison (n=107). Accuracy of this new renin assay was tested using the International Standard (WHO IS 68\/356). We also assessed the equivalence of the different samples types (n=29).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2022-0576_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The imprecision evaluation showed all CVs &lt;3% and &lt;6% for Lumipulse<jats:sup>\u00ae<\/jats:sup> G Aldosterone and Renin assays respectively. The linearity was excellent over the clinical range and the comparison with the iSYS<jats:sup>\u00ae<\/jats:sup> assays (n=79) showed a strong correlation (R<jats:sup>2<\/jats:sup>=1) despite a slight tendency to underestimation (bias of\u00a0\u221217.53\u00a0pg\/mL or 48.56\u00a0pmol\/L for aldosterone and\u00a0\u221215.395\u00a0pg\/mL for renin). Moreover, the contingency studies based on diagnostic criteria showed that Lumipulse<jats:sup>\u00ae<\/jats:sup> G results lead to the same clinical diagnosis that iSYS<jats:sup>\u00ae<\/jats:sup> results. A clear correlation was obtained between EDTA and heparin plasma as well as with the serum for all range of measures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2022-0576_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The Lumipulse<jats:sup>\u00ae<\/jats:sup> G Aldosterone and Renin assays present performances compatible with a routine use\u00a0in medical laboratories. The precise quantification in the low range can be of interest in some clinical contexts especially standing\/laying tests. However, the standardisation against the WHO International Standard Renin would be advisable.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/cclm-2022-0576","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T23:36:32Z","timestamp":1663025792000},"page":"1763-1771","source":"Crossref","is-referenced-by-count":2,"title":["Analytical evaluation and bioclinical validation of new aldosterone and renin immunoassays"],"prefix":"10.1515","volume":"60","author":[{"given":"Caroline","family":"Coulon","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Hormonology , University Hospital of Montpellier , Montpellier , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7555-5129","authenticated-orcid":false,"given":"Manuela","family":"Lotierzo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Hormonology , University Hospital of Montpellier , Montpellier , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Fesler","sequence":"additional","affiliation":[{"name":"Internal Medicine Service, University Hospital of Montpellier, PhyMedExp, University of Montpellier, INSERM, CNRS , Montpellier , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camille","family":"Roubille","sequence":"additional","affiliation":[{"name":"Internal Medicine Service, University Hospital of Montpellier, PhyMedExp, University of Montpellier, INSERM, CNRS , Montpellier , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phanie","family":"Badiou","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Hormonology , University Hospital of Montpellier, PhyMedExp, University of Montpellier, INSERM, CNRS , Montpellier , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6538-3944","authenticated-orcid":false,"given":"Anne Marie","family":"Dupuy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Hormonology , University Hospital of Montpellier , Montpellier , France"},{"name":"Centre de Ressources Biologiques, University Hospital of Montpellier , Montpellier , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Paul","family":"Cristol","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Hormonology , University Hospital of Montpellier, PhyMedExp, University of Montpellier, INSERM, CNRS , Montpellier , France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,9,13]]},"reference":[{"key":"2023033113340204368_j_cclm-2022-0576_ref_001","doi-asserted-by":"crossref","unstructured":"K\u00e4yser, SC, Dekkers, T, Groenewoud, HJ, Van Der Wilt, GJ, Carel Bakx, J, Van Der Wel, MC, et al.. 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