{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:36:20Z","timestamp":1791592580323,"version":"4.3.4"},"reference-count":40,"publisher":"Walter de Gruyter GmbH","issue":"8","license":[{"start":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T00:00:00Z","timestamp":1679616000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"The Swedish Heart and Lung Foundation"},{"name":"The Swedish Cancer Society"},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation.","doi-asserted-by":"crossref","award":["CH\/F\/21\/90010, RG\/20\/10\/34966, RE\/18\/5\/34216"],"award-info":[{"award-number":["CH\/F\/21\/90010, RG\/20\/10\/34966, RE\/18\/5\/34216"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The International Federation of Clinical Chemistry Committee on Clinical Applications of Cardiac Biomarkers (IFCC C-CB) provides educational documents to facilitate the interpretation and use of cardiac biomarkers in clinical laboratories and practice. Our aim is to improve the understanding of certain key analytical and clinical aspects of cardiac biomarkers and how these may interplay. Measurements of cardiac troponin (cTn) have a prominent place in the clinical work-up of patients with suspected acute coronary syndrome. It is therefore important that clinical laboratories know how to recognize and assess analytical issues. Two emerging analytical issues resulting in falsely high cTn concentrations, often several fold higher than the upper reference limit (URL), are antibody-mediated assay interference due to long-lived cTn-antibody complexes, called macrotroponin, and crosslinking antibodies that are frequently referred to as heterophilic antibodies. We provide an overview of antibody-mediated cTn assay interference and provide recommendations on how to confirm the interference and interpret the results.<\/jats:p>","DOI":"10.1515\/cclm-2023-0028","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T21:05:28Z","timestamp":1679605528000},"page":"1411-1419","source":"Crossref","is-referenced-by-count":60,"title":["Antibody-mediated interferences affecting cardiac troponin assays: recommendations from the IFCC Committee on Clinical Applications of Cardiac Biomarkers"],"prefix":"10.1515","volume":"61","author":[{"given":"Ola","family":"Hammarsten","sequence":"first","affiliation":[{"name":"Department of Clinical Chemistry and Transfusion Medicine , University of Gothenburg , Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet V.","family":"Warner","sequence":"additional","affiliation":[{"name":"Faculty of Medicine , The University of Queensland , Saint Lucia , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Lam","sequence":"additional","affiliation":[{"name":"Chemical Pathology, LabPlus , Auckland City Hospital , Auckland , New Zealand"},{"name":"Biochemistry , Middlemore Hospital Laboratories , Auckland , New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kavsak","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine , McMaster University , Hamilton , ON , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertil","family":"Lindahl","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences , Uppsala University and Uppsala Clinical Research Center, Uppsala University , Uppsala , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7340-6736","authenticated-orcid":false,"given":"Kristin M.","family":"Aakre","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Pharmacology and Department of Heart Disease , Haukeland University\u00a0Hospital , Bergen , Norway"},{"name":"Department of Clinical Science , University of Bergen , Bergen , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7000-5996","authenticated-orcid":false,"given":"Paul","family":"Collinson","sequence":"additional","affiliation":[{"name":"Departments of Clinical Blood Sciences and Cardiology , St George\u2019s University Hospitals NHS Foundation Trust , London , UK"},{"name":"St George\u2019s University of London , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan S.","family":"Jaffe","sequence":"additional","affiliation":[{"name":"Departments of Laboratory Medicine and Pathology and Cardiology , Mayo Clinic , Rochester , MN , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy K.","family":"Saenger","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology , Hennepin Healthcare\/HCMC , Minneapolis , MN , USA"},{"name":"Department of Laboratory Medicine and Pathology , University of Minnesota , Minneapolis , MN , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Body","sequence":"additional","affiliation":[{"name":"Emergency Department , Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre , Manchester , UK"},{"name":"Division of Cardiovascular Sciences , The University of Manchester , Manchester , UK"},{"name":"Healthcare Sciences Department , Manchester Metropolitan University , Manchester , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas L.","family":"Mills","sequence":"additional","affiliation":[{"name":"BHF\/University Centre for Cardiovascular Science and Usher Institute, University of Edinburgh , Edinburgh , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torbj\u00f8rn","family":"Omland","sequence":"additional","affiliation":[{"name":"Department of Cardiology , Akershus University Hospital , L\u00f8renskog , Norway"},{"name":"Institute of Clinical Medicine, University of Oslo , Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Ordonez-Llanos","sequence":"additional","affiliation":[{"name":"Servicio de Bioqu\u00edmica Cl\u00ednica , Hospital de Sant Pau , Barcelona , Spain"},{"name":"Foundation for the Biochemistry and Molecular Pathology , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred S.","family":"Apple","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology , Hennepin Healthcare\/HCMC , Minneapolis , MN , USA"},{"name":"Department of Laboratory Medicine and Pathology , 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