{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:52:02Z","timestamp":1778827922060,"version":"3.51.4"},"reference-count":37,"publisher":"Walter de Gruyter GmbH","issue":"11","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["grant number 82172327"],"award-info":[{"award-number":["grant number 82172327"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_cclm-2023-0236_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The clinical significance of serum pepsinogen (PG) for screening gastric cancer has been a controversial topic. Serum PG I levels have been demonstrated to be correlated with age, sex, and the <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>HP<\/jats:italic>) infection. However, the underlying factors that influence serum PG I variations remain to be fully elucidated. We aimed to evaluate the impacts of sex and body mass index (BMI) on PG I in Chinese population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2023-0236_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The cross-sectional study recruited 4,299 apparently healthy participants in Fujian Province. Serum PG levels were automatically measured using ELISA method. Serum <jats:italic>H.\u00a0pylori<\/jats:italic>-IgG antibody was detected by the colloidal gold immunoassay. Clinical characteristics were obtained by questionnaire.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2023-0236_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Totally, 2,263 participants who had tests of serum PG and anti-HP IgG antibody were enrolled. Increased BMI and serum uric acid were observed in males with low PG I value (&lt;70\u202f\u03bcg\/L). Multiple logistic regression showed the presence of overweight was the independent risk factor for male participants with low PG I level (odds ratio [OR] 1.519; p=0.017). However, the association was not found in females.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2023-0236_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Sex-specific association of serum low PG I with overweight was observed in the southeast coastal areas of China. Thus, effects of sexual dimorphism should not be ignored during the clinical utilization of serum PG I.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/cclm-2023-0236","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T13:29:35Z","timestamp":1683898175000},"page":"2010-2016","source":"Crossref","is-referenced-by-count":4,"title":["Sex-specific disparities of serum pepsinogen I in relation to body mass index"],"prefix":"10.1515","volume":"61","author":[{"given":"Wenshen","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine , the First Affiliated Hospital, Fujian Medical University , Fuzhou , P.R. China"},{"name":"Department of Laboratory Medicine , National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University , Fuzhou , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine , the First Affiliated Hospital, Fujian Medical University , Fuzhou , P.R. China"},{"name":"Department of Laboratory Medicine , National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University , Fuzhou , P.R. China"},{"name":"Fujian Key Laboratory of Laboratory Medicine, the First Affiliated Hospital, Fujian Medical University , Fuzhou , Fujian , P.R. China"},{"name":"Gene Diagnosis Research Center, Fujian Medical University , Fuzhou , P.R. China"},{"name":"Fujian Clinical Research Center for Clinical Immunology Laboratory Test, the First Affiliated Hospital, Fujian Medical University , Fuzhou , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine , the First Affiliated Hospital, Fujian Medical University , Fuzhou , P.R. China"},{"name":"Department of Laboratory Medicine , National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University , Fuzhou , P.R. China"},{"name":"Fujian Key Laboratory of Laboratory Medicine, the First Affiliated Hospital, Fujian Medical University , Fuzhou , Fujian , P.R. China"},{"name":"Gene Diagnosis Research Center, Fujian Medical University , Fuzhou , P.R. China"},{"name":"Fujian Clinical Research Center for Clinical Immunology Laboratory Test, the First Affiliated Hospital, Fujian Medical University , Fuzhou , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuguo","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine , the First Affiliated Hospital, Fujian Medical University , Fuzhou , P.R. China"},{"name":"Department of Laboratory Medicine , National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University , Fuzhou , P.R. China"},{"name":"Gene Diagnosis Research Center, Fujian Medical University , Fuzhou , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine , the First Affiliated Hospital, Fujian Medical University , Fuzhou , P.R. China"},{"name":"Department of Laboratory Medicine , National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University , Fuzhou , P.R. 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N Engl J Med 2011;364:719\u201329. https:\/\/doi.org\/10.1056\/nejmoa1010679.","DOI":"10.1056\/NEJMoa1010679"},{"key":"2023100313544671236_j_cclm-2023-0236_ref_004","doi-asserted-by":"crossref","unstructured":"Wu, Y, Li, Y, Giovannucci, E. Potential impact of time trend of lifestyle risk factors on burden of major gastrointestinal cancers in China. Gastroenterology 2021;161:1830\u201341.e8. https:\/\/doi.org\/10.1053\/j.gastro.2021.08.006.","DOI":"10.1053\/j.gastro.2021.08.006"},{"key":"2023100313544671236_j_cclm-2023-0236_ref_005","doi-asserted-by":"crossref","unstructured":"Lee, HW, Huang, D, Shin, WK, de la Torre, K, Yang, JJ, Song, M, et al.. Obesity at early adulthood increases risk of gastric cancer from the Health Examinees-Gem (HEXA-G) study. PLoS One 2022;17:e0260826. https:\/\/doi.org\/10.1371\/journal.pone.0260826.","DOI":"10.1371\/journal.pone.0260826"},{"key":"2023100313544671236_j_cclm-2023-0236_ref_006","doi-asserted-by":"crossref","unstructured":"Larsson, SC, Burgess, S. Causal role of high body mass index in multiple chronic diseases: a systematic review and meta-analysis of Mendelian randomization studies. BMC Med 2021;19:320. https:\/\/doi.org\/10.1186\/s12916-021-02188-x.","DOI":"10.1186\/s12916-021-02188-x"},{"key":"2023100313544671236_j_cclm-2023-0236_ref_007","doi-asserted-by":"crossref","unstructured":"Loosen, SH, Roderburg, C, J\u00f6rdens, MS, Fluegen, G, Luedde, T, Kostev, K. Overweight and obesity determine the risk for gastrointestinal cancer in a sex-dependent manner: a retrospective cohort study of 287,357 outpatients in Germany. Cancers (Basel) 2022;14:931. https:\/\/doi.org\/10.3390\/cancers14040931.","DOI":"10.3390\/cancers14040931"},{"key":"2023100313544671236_j_cclm-2023-0236_ref_008","doi-asserted-by":"crossref","unstructured":"Nam, SY, Jeong, J, Lee, WK, Jeon, SW. Sex-specific effect of body mass index and fasting glucose on gastric cancer risk and all causes mortality; a cohort study of 5.17 million. Int J Obes (Lond) 2022;46:1644\u201351. https:\/\/doi.org\/10.1038\/s41366-022-01161-9.","DOI":"10.1038\/s41366-022-01161-9"},{"key":"2023100313544671236_j_cclm-2023-0236_ref_009","doi-asserted-by":"crossref","unstructured":"Sung, H, Ferlay, J, Siegel, RL, Laversanne, M, Soerjomataram, I, Jemal, A, et al.. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA A Cancer J Clin 2021;71:209\u201349. https:\/\/doi.org\/10.3322\/caac.21660.","DOI":"10.3322\/caac.21660"},{"key":"2023100313544671236_j_cclm-2023-0236_ref_010","unstructured":"Gastric Cancer Association, CACA. Consensus of Chinese expert panel on key difficult points of diagnosis and treatment in gastric cancer (2020 edition). Chin J Practical Surg 2020;8:869\u2013904."},{"key":"2023100313544671236_j_cclm-2023-0236_ref_011","doi-asserted-by":"crossref","unstructured":"Cai, Q, Zhu, C, Yuan, Y, Feng, Q, Feng, Y, Hao, Y, et al.. Development and validation of a prediction rule for estimating gastric cancer risk in the Chinese high-risk population: a nationwide multicentre study. Gut 2019;68:1576\u201387. https:\/\/doi.org\/10.1136\/gutjnl-2018-317556.","DOI":"10.1136\/gutjnl-2018-317556"},{"key":"2023100313544671236_j_cclm-2023-0236_ref_012","doi-asserted-by":"crossref","unstructured":"Chapelle, N, Petryszyn, P, Blin, J, Leroy, M, Le Berre-Scoul, C, Jirka, I, et al.. A panel of stomach-specific biomarkers (GastroPanel\u00ae) for the diagnosis of atrophic gastritis: a prospective, multicenter study in a low gastric cancer incidence area. Helicobacter 2020;25:e12727. https:\/\/doi.org\/10.1111\/hel.12727.","DOI":"10.1111\/hel.12727"},{"key":"2023100313544671236_j_cclm-2023-0236_ref_013","doi-asserted-by":"crossref","unstructured":"Chiang, TH, Chiu, SY, Chen, SL, Yen, AM, Fann, JC, Liu, CY, et al.. Serum pepsinogen as a predictor for gastric cancer death: a 16-year community-based cohort study. J Clin Gastroenterol 2019;53:e186\u201393. https:\/\/doi.org\/10.1097\/mcg.0000000000000992.","DOI":"10.1097\/MCG.0000000000000992"},{"key":"2023100313544671236_j_cclm-2023-0236_ref_014","doi-asserted-by":"crossref","unstructured":"Fock, KM, Talley, N, Moayyedi, P, Hunt, R, Azuma, T, Sugano, K, et al.. Asia-Pacific consensus guidelines on gastric cancer prevention. 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