{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T12:16:05Z","timestamp":1792844165138,"version":"4.5.0"},"reference-count":8,"publisher":"Walter de Gruyter GmbH","issue":"6","license":[{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,27]]},"DOI":"10.1515\/cclm-2023-1096","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T17:02:06Z","timestamp":1704906126000},"page":"e129-e131","source":"Crossref","is-referenced-by-count":3,"title":["Impact of hemolysis on uracilemia in the context of dihydropyrimidine dehydrogenase deficiency testing"],"prefix":"10.1515","volume":"62","author":[{"given":"Gaspard","family":"Loison","sequence":"first","affiliation":[{"name":"Laboratory of Pharmacology , Oncopole Claudius Regaud , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Bouges Le Royer","sequence":"additional","affiliation":[{"name":"Laboratory of Oncopharmacology , Centre Antoine Lacassagne , Nice , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Marsili","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology , Oncopole Claudius Regaud , Toulouse , France"},{"name":"Centre de Recherche en Canc\u00e9rologie de Toulouse, INSERM U1037 , Universit\u00e9 Paul Sabatier , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Brice","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology , Oncopole Claudius Regaud , Toulouse , France"},{"name":"Centre de Recherche en Canc\u00e9rologie de Toulouse, INSERM U1037 , Universit\u00e9 Paul Sabatier , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Vintejoux","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology , Oncopole Claudius Regaud , Toulouse , France"},{"name":"Centre de Recherche en Canc\u00e9rologie de Toulouse, INSERM U1037 , Universit\u00e9 Paul Sabatier , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malika","family":"Yakoubi","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology , Oncopole Claudius Regaud , Toulouse , France"},{"name":"Centre de Recherche en Canc\u00e9rologie de Toulouse, INSERM U1037 , Universit\u00e9 Paul Sabatier , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Sirgue","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology , Oncopole Claudius Regaud , Toulouse , France"},{"name":"Centre de Recherche en Canc\u00e9rologie de Toulouse, INSERM U1037 , Universit\u00e9 Paul Sabatier , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Chatelut","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology , Oncopole Claudius Regaud , Toulouse , France"},{"name":"Centre de Recherche en Canc\u00e9rologie de Toulouse, INSERM U1037 , Universit\u00e9 Paul Sabatier , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christine","family":"Etienne-Grimaldi","sequence":"additional","affiliation":[{"name":"Laboratory of Oncopharmacology , Centre Antoine Lacassagne , Nice , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9886-412X","authenticated-orcid":false,"given":"Fabienne","family":"Thomas","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology , Oncopole Claudius Regaud , Toulouse , France"},{"name":"University Paul Sabatier , Toulouse , France"},{"name":"Centre de Recherche en Canc\u00e9rologie de Toulouse, INSERM U1037 , Universit\u00e9 Paul Sabatier , Toulouse , France"},{"name":"Institut Universitaire du Cancer Toulouse\u00a0\u2013 Oncopole , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2024,1,11]]},"reference":[{"key":"2024042909564479746_j_cclm-2023-1096_ref_001","doi-asserted-by":"crossref","unstructured":"Ezzeldin, H, Diasio, R. Dihydropyrimidine dehydrogenase deficiency, a pharmacogenetic syndrome associated with potentially life-threatening toxicity following 5-fluorouracil administration. Clin Colorectal Cancer 2004;4:181\u20139. https:\/\/doi.org\/10.3816\/ccc.2004.n.018.","DOI":"10.3816\/CCC.2004.n.018"},{"key":"2024042909564479746_j_cclm-2023-1096_ref_002","doi-asserted-by":"crossref","unstructured":"Barin-Le Guellec, C, Lafay-Chebassier, C, Ingrand, I, Tournamille, JF, Boudet, A, Lanoue, MC, et al.. Toxicities associated with chemotherapy regimens containing a fluoropyrimidine: a real-life evaluation in France. Eur J Cancer 2020;124:37\u201346. https:\/\/doi.org\/10.1016\/j.ejca.2019.09.028.","DOI":"10.1016\/j.ejca.2019.09.028"},{"key":"2024042909564479746_j_cclm-2023-1096_ref_003","doi-asserted-by":"crossref","unstructured":"Boisdron-Celle, M, Remaud, G, Traore, S, Poirier, AL, Gamelin, L, Morel, A, et al.. 5-Fluorouracil-related severe toxicity: a comparison of different methods for the pretherapeutic detection of dihydropyrimidine dehydrogenase deficiency. Cancer Lett 2007;249:271\u201382. https:\/\/doi.org\/10.1016\/j.canlet.2006.09.006.","DOI":"10.1016\/j.canlet.2006.09.006"},{"key":"2024042909564479746_j_cclm-2023-1096_ref_004","unstructured":"HAS. Screening for dihydropyrimidine dehydrogenase deficiency to decrease the risk of severe toxicities related to fluoropyrimidines (5-fluorouracil or capecitabine). [Internet]. Available from: https:\/\/www.has-sante.fr\/upload\/docs\/application\/pdf\/2018-12\/recherche_dun_deficit_en_dihydropyrimidine_deshydrogenase_visant_a_prevenir_certaines_toxicites_severes_associees_aux_traite.pdf."},{"key":"2024042909564479746_j_cclm-2023-1096_ref_005","doi-asserted-by":"crossref","unstructured":"Maillard, M, Launay, M, Royer, B, Guitton, J, Gautier-Veyret, E, Broutin, S, et al., Groupe de Pharmacologie Clinique Oncologique (GPCO). Quantitative impact of pre-analytical process on plasma uracil when testing for dihydropyrimidine dehydrogenase deficiency. Br J Clin Pharmacol 2023;89:762\u201372. https:\/\/doi.org\/10.1111\/bcp.15536.","DOI":"10.1111\/bcp.15536"},{"key":"2024042909564479746_j_cclm-2023-1096_ref_006","doi-asserted-by":"crossref","unstructured":"Heireman, L, Van Geel, P, Musger, L, Heylen, E, Uyttenbroeck, W, Mahieu, B. Causes, consequences and management of sample hemolysis in the clinical laboratory. Clin Biochem 2017;50:1317\u201322. https:\/\/doi.org\/10.1016\/j.clinbiochem.2017.09.013.","DOI":"10.1016\/j.clinbiochem.2017.09.013"},{"key":"2024042909564479746_j_cclm-2023-1096_ref_007","doi-asserted-by":"crossref","unstructured":"Ingelse, B, Barroso, B, Gray, N, Jakob-Rodamer, V, Kingsley, C, Sykora, C, et al.. European Bioanalysis Forum: recommendation on dealing with\u00a0hemolyzed and hyperlipidemic matrices. Bioanalysis 2014;6:3113\u201320. https:\/\/doi.org\/10.4155\/bio.14.252.","DOI":"10.4155\/bio.14.252"},{"key":"2024042909564479746_j_cclm-2023-1096_ref_008","doi-asserted-by":"crossref","unstructured":"Kuilenburg, ABPV, Lenthe, H, Blom, MJ, Mul, EPJ, Gennip, AHV. Profound variation in dihydropyrimidine dehydrogenase activity in human blood cells: major implications for the detection of partly deficient patients. Br J Cancer 1999;79:620\u20136. https:\/\/doi.org\/10.1038\/sj.bjc.6690097.","DOI":"10.1038\/sj.bjc.6690097"}],"container-title":["Clinical Chemistry and Laboratory Medicine (CCLM)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/cclm-2023-1096\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/cclm-2023-1096\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T09:59:16Z","timestamp":1714384756000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/cclm-2023-1096\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,11]]},"references-count":8,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,3,27]]},"published-print":{"date-parts":[[2024,5,27]]}},"alternative-id":["10.1515\/cclm-2023-1096"],"URL":"https:\/\/doi.org\/10.1515\/cclm-2023-1096","relation":{},"ISSN":["1434-6621","1437-4331"],"issn-type":[{"value":"1434-6621","type":"print"},{"value":"1437-4331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,11]]}}}