{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T09:27:49Z","timestamp":1793179669510,"version":"4.5.0"},"reference-count":26,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_cclm-2023-1238_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare for the first time the performance of \u201cGFAP and UCH-L1\u201d vs. S100B in a cohort of patients managed for mild traumatic brain injury (mTBI) according to actualized French guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2023-1238_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A prospective study was recently carried at the Emergency Department of Clermont-Ferrand University Hospital in France. Patients with mTBI presenting a medium risk of complications were enrolled. Blood S100B and \u201cGFAP and UCHL-1\u201d were sampled and measured according to French guidelines. S100B was measured in patients with samples within 3\u202fh of trauma (Cobas\n                      <jats:sup>\u00ae<\/jats:sup>\n                      , Roche Diagnostics), while GFAP and UCHL-1 were measured in all patients (samples &lt;3\u202fh and 3\u201312\u202fh) using another automated assay (i-STAT\n                      <jats:sup>\u00ae<\/jats:sup>\n                      Alinity, Abbott).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2023-1238_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>For sampling &lt;3\u202fh, serum S100B correctly identifies intracranial lesions with a specificity of 25.7\u202f% (95\u202f% CI; 19.5\u201332.6\u202f%), a sensitivity of 100\u202f% (95\u202f% CI; 66.4\u2013100\u202f%), and a negative predictive value of 100\u202f% (95\u202f% CI; 92.5\u2013100\u202f%). For sampling &lt;12\u202fh, plasma \u201cGFAP and UCH-L1\u201d levels correctly identify intracranial lesions with a specificity of 31.7\u202f% (95\u202f% CI; 25.7\u201338.2\u202f%), a sensitivity of 100\u202f% (95\u202f% CI; 73.5\u2013100\u202f%), and a negative predictive value of 100\u202f% (95\u202f% CI; 95\u2013100\u202f%). Comparison of specificities (25.7 vs. 31.7\u202f%) did not reveal a statistically significant difference (p=0.16).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2023-1238_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We highlight the usefulness of measuring plasma \u201cGFAP and UCH-L1\u201d levels to target mTBI patients (sampling within 12\u202fh post-injury) and optimize the reduction of CT scans.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/cclm-2023-1238","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T11:12:01Z","timestamp":1701342721000},"page":"891-899","source":"Crossref","is-referenced-by-count":25,"title":["S100B vs. \u201cGFAP and UCH-L1\u201d assays in the management of mTBI patients"],"prefix":"10.1515","volume":"62","author":[{"given":"Charlotte","family":"Oris","sequence":"first","affiliation":[{"name":"Biochemistry and Molecular Genetic Department , CHU Clermont-Ferrand , Clermont-Ferrand , France"},{"name":"Universit\u00e9 Clermont Auvergne, CNRS, INSERM, GReD , Clermont-Ferrand , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Baptiste","family":"Bouillon-Minois","sequence":"additional","affiliation":[{"name":"Adult Emergency Department , CHU Clermont-Ferrand , Clermont-Ferrand , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5918-1315","authenticated-orcid":false,"given":"Samy","family":"Kahouadji","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Genetic Department , CHU Clermont-Ferrand , Clermont-Ferrand , France"},{"name":"Universit\u00e9 Clermont Auvergne, CNRS, INSERM, GReD , Clermont-Ferrand , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Pereira","sequence":"additional","affiliation":[{"name":"Biostatistics Unit (DRCI) , CHU Clermont-Ferrand , Clermont-Ferrand , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Dhaiby","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Genetic Department , CHU Clermont-Ferrand , Clermont-Ferrand , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin Bailly","family":"Defrance","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Genetic Department , CHU Clermont-Ferrand , Clermont-Ferrand , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Durif","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Genetic Department , CHU Clermont-Ferrand , Clermont-Ferrand , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannot","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Adult Emergency Department , CHU Clermont-Ferrand , Clermont-Ferrand , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Far\u00e8s","family":"Moustafa","sequence":"additional","affiliation":[{"name":"Adult Emergency Department , CHU Clermont-Ferrand , Clermont-Ferrand , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Bouvier","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Genetic Department , CHU Clermont-Ferrand , Clermont-Ferrand , France"},{"name":"Universit\u00e9 Clermont Auvergne, CNRS, INSERM, GReD , Clermont-Ferrand , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7452-315X","authenticated-orcid":false,"given":"Vincent","family":"Sapin","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Genetic Department , CHU Clermont-Ferrand , Clermont-Ferrand , France"},{"name":"Universit\u00e9 Clermont Auvergne, CNRS, INSERM, GReD , Clermont-Ferrand , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2023,12,1]]},"reference":[{"key":"2026051214033877340_j_cclm-2023-1238_ref_001","doi-asserted-by":"crossref","unstructured":"Oris, C, Kahouadji, S, Durif, J, Bouvier, D, Sapin, V. 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