{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T07:06:21Z","timestamp":1770966381383,"version":"3.50.1"},"reference-count":24,"publisher":"Walter de Gruyter GmbH","issue":"6","license":[{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_cclm-2023-1292_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Tubular maximum phosphate reabsorption per glomerular filtration rate (TmP\/GFR) is used to evaluate renal phosphate reabsorption and it is a useful tool for the differential diagnosis of hypophosphatemic syndromes. TmP\/GFR is typically calculated from fasting plasma and second morning void urine samples, obtained 2\u202fh after the first void (TmP\/GFR 2\u202fh). The purpose of this study was to evaluate if TmP\/GFR calculated from 24\u202fh urine collection (TmP\/GFR 24\u202fh) can be used as an alternative for TmP\/GFR 2\u202fh in patients with urine phosphate wasting.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2023-1292_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We enrolled adult patients with X-linked hypophosphatemia (XLH) or tumor-induced osteomalacia (TIO). All patients underwent blood and urine sample collections, to calculate TmP\/GFR 24\u202fh and TmP\/GFR 2\u202fh.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2023-1292_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Twenty patients (17 XLH and 3 TIO), aged 24\u201378 years, were included. All patients had low TmP\/GFR 2\u202fh (0.35\u202fmmol\/L, IQR 0.24\u20130.47\u202fmmol\/L) and TmP\/GFR 24\u202fh (0.31\u202fmmol\/L, IQR 0.22\u20130.43\u202fmmol\/L). The concordance correlation coefficient between TmP\/GFR 2\u202fh and TmP\/GFR 24\u202fh was 0.86 (95\u202f% CI: 0.69\u20130.93), with a systematic bias of 0.05\u202fmmol\/L (95\u202f% limits of agreement:\u00a0\u22120.10 to 0.20). Furthermore, in 70\u202f% (i.e.,\u00a014 patients out of 20) and 80\u202f% (i.e.,\u00a016 patients out of 20) of cases the difference between TmP\/GFR 2\u202fh and TmP\/GFR 24\u202fh was within \u00b130\u202f% and \u00b135\u202f%, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2023-1292_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Despite TmP\/GFR 2 and 24\u202fh show a relatively suboptimal agreement, the difference between the two parameters appears to be small and not clinically significant in the setting of adult patients with FGF23-dependent urine phosphate wasting and secondary hypophosphatemia.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/cclm-2023-1292","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T16:48:28Z","timestamp":1706633308000},"page":"1126-1132","source":"Crossref","is-referenced-by-count":6,"title":["Tubular phosphate transport: a comparison between different methods of urine sample collection in FGF23-dependent hypophosphatemic syndromes"],"prefix":"10.1515","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0409-4449","authenticated-orcid":false,"given":"Gaetano Paride","family":"Arcidiacono","sequence":"first","affiliation":[{"name":"Department of Medicine, Clinica Medica 1 , University of Padova , Padova , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Camozzi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Endocrinology Unit , University of Padova , Padova , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Zaninotto","sequence":"additional","affiliation":[{"name":"Department of Medicine, Laboratory Medicine Unit , University of Padova , Padova , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Tripepi","sequence":"additional","affiliation":[{"name":"National Research Council (CNR) , Institute of Clinical Physiology (IFC), Clinical Epidemiology of Renal Diseases and Hypertension, Ospedali Riuniti , Reggio Calabria , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Fusaro","sequence":"additional","affiliation":[{"name":"National Research Council (CNR) , Institute of Clinical Physiology (IFC) , Pisa , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Onofrio","family":"Torres","sequence":"additional","affiliation":[{"name":"Department of Medicine, Clinica Medica 1 , University of Padova , Padova , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Zanchetta","sequence":"additional","affiliation":[{"name":"Department of Medicine, Clinica Medica 1 , University of Padova , Padova , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Cannito","sequence":"additional","affiliation":[{"name":"Department of Medicine, Endocrinology Unit , University of Padova , Padova , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberta","family":"Cecchinato","sequence":"additional","affiliation":[{"name":"Department of Medicine, Clinica Medica 1 , University of Padova , Padova , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Diogo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Clinica Medica 1 , University of Padova , Padova , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mor","family":"Peleg Falb","sequence":"additional","affiliation":[{"name":"Department of Medicine, Clinica Medica 1 , University of Padova , Padova , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0270-1711","authenticated-orcid":false,"given":"Mario","family":"Plebani","sequence":"additional","affiliation":[{"name":"Department of Medicine, Laboratory Medicine Unit , University of Padova , Padova , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6744-383X","authenticated-orcid":false,"given":"Paolo","family":"Simioni","sequence":"additional","affiliation":[{"name":"Department of Medicine, General Medicine and Thrombotic and Hemorrhagic Diseases Unit , University of Padova , Padova , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Sella","sequence":"additional","affiliation":[{"name":"Department of Medicine, Clinica Medica 1 , University of Padova , Padova , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0796-9749","authenticated-orcid":false,"given":"Sandro","family":"Giannini","sequence":"additional","affiliation":[{"name":"Department of Medicine, Clinica Medica 1 , University of Padova , Padova , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2024,1,31]]},"reference":[{"key":"2024042909564460687_j_cclm-2023-1292_ref_001","doi-asserted-by":"crossref","unstructured":"Marks, J, Debnam, ES, Unwin, RJ. 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