{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:48:25Z","timestamp":1791841705842,"version":"4.3.4"},"reference-count":50,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_cclm-2023-1297_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Concentrations of neopterin, kynurenine and kynurenine\/tryptophan ratios predict prognosis and the need for oxygen therapy in patients hospitalized for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The aims of the present study were to evaluate the changes of these biomarkers early in the course of infection, the association with the prior coronavirus disease (COVID-19) vaccination and therapeutic administration of Anti-SARS-CoV-2 monoclonal antibodies, investigation of other potential biomarkers including neuropilin, 8-hydroxy-2-deoxyguanosine and 8-hydroxyguanosine in patients hospitalized with SARS-CoV-2 infection and an assessment of these biomarkers and vitamins A, E and D in patients with post-COVID syndrome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2023-1297_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Urine and blood samples were obtained on the 1st to the 4th day and 4th to 7th day from 108 patients hospitalized with COVID-19. Chromatography tandem mass spectrometry methods were used to analyse neopterin, kynurenine, tryptophan, liposoluble vitamins, and DNA damage biomarkers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2023-1297_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A statistically significant decrease of neopterin, kynurenine and kynurenine\/tryptophan ratios was observed on after 4th to 7th day of hospitalization, and concentrations of these biomarkers were increased in patients with poor prognosis and subsequent post-COVID syndrome. The concentrations of remaining biomarker and vitamins were not associated with outcomes, although markedly decreased concentrations of vitamin A, E and D were noted.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_cclm-2023-1297_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The concentrations of neopterin, kynurenine and kynurenine\/tryptophan ratios decrease during the course of infection SARS-CoV-2 and are associated with the post-COVID syndrome. No other prognostic biomarkers were identified.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/cclm-2023-1297","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T07:10:37Z","timestamp":1708413037000},"page":"1217-1227","source":"Crossref","is-referenced-by-count":15,"title":["Evaluation of inflammatory biomarkers and vitamins in hospitalized patients with SARS-CoV-2 infection and post-COVID syndrome"],"prefix":"10.1515","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3825-0294","authenticated-orcid":false,"given":"Lenka Kujovsk\u00e1","family":"Kr\u010dmov\u00e1","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry and Diagnostics , University Hospital Hradec Kr\u00e1lov\u00e9 , Hradec Kr\u00e1lov\u00e9 , Czech Republic"},{"name":"Department of Analytical Chemistry, Faculty of Pharmacy in Hradec Kr\u00e1lov\u00e9 , Charles University , Hradec Kr\u00e1lov\u00e9 , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenka","family":"Javorsk\u00e1","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and Diagnostics , University Hospital Hradec Kr\u00e1lov\u00e9 , Hradec Kr\u00e1lov\u00e9 , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8283-5770","authenticated-orcid":false,"given":"Kate\u0159ina","family":"Matou\u0161ov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and Diagnostics , University Hospital Hradec Kr\u00e1lov\u00e9 , Hradec Kr\u00e1lov\u00e9 , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"\u0160mahel","sequence":"additional","affiliation":[{"name":"Deparment of Infectious Diseases , University Hospital Hradec Kr\u00e1lov\u00e9 , Hradec Kr\u00e1lov\u00e9 , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikul\u00e1\u0161","family":"Sk\u00e1la","sequence":"additional","affiliation":[{"name":"Department of Pneumology , University Hospital Hradec Kr\u00e1lov\u00e9 , Hradec Kr\u00e1lov\u00e9 , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Kopeck\u00fd","sequence":"additional","affiliation":[{"name":"Department of Pneumology , University Hospital Hradec Kr\u00e1lov\u00e9 , Hradec Kr\u00e1lov\u00e9 , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaweewan","family":"Suwanvecho","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and Diagnostics , University Hospital Hradec Kr\u00e1lov\u00e9 , Hradec Kr\u00e1lov\u00e9 , Czech Republic"},{"name":"Department of Analytical Chemistry, Faculty of Pharmacy in Hradec Kr\u00e1lov\u00e9 , Charles University , Hradec Kr\u00e1lov\u00e9 , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola","family":"P\u0159\u00edvratsk\u00e1","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and Diagnostics , University Hospital Hradec Kr\u00e1lov\u00e9 , Hradec Kr\u00e1lov\u00e9 , Czech Republic"},{"name":"Department of Analytical Chemistry, Faculty of Pharmacy in Hradec Kr\u00e1lov\u00e9 , Charles University , Hradec Kr\u00e1lov\u00e9 , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Turo\u0148ov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and Diagnostics , University Hospital Hradec Kr\u00e1lov\u00e9 , Hradec Kr\u00e1lov\u00e9 , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bohuslav","family":"Melichar","sequence":"additional","affiliation":[{"name":"Department of Oncology, Faculty of Medicine and Dentistry , Palack\u00fd University , Olomouc , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2024,2,21]]},"reference":[{"key":"2024042909564501024_j_cclm-2023-1297_ref_001","doi-asserted-by":"crossref","unstructured":"Anka, AU, Tahir, MI, Abubakar, SD, Alsabbagh, M, Zian, Z, Hamedifar, H, et al.. 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