{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:08:47Z","timestamp":1787022527179,"version":"build-2736575974"},"reference-count":50,"publisher":"Walter de Gruyter GmbH","issue":"1","funder":[{"DOI":"10.13039\/501100014913","name":"Freistaat Sachsen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014913","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023651","name":"Europ\u00e4ischer Sozialfonds","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023651","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_cclm-2024-0369_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Soluble transferrin receptor (sTfR) is a marker of both erythropoiesis and iron status and is considered useful for detecting iron deficiency, especially in inflammatory conditions, but reference intervals covering the entire pediatric age spectrum are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2024-0369_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied 1,064 (48.5\u202f% female) healthy children of the entire pediatric age spectrum to determine reference values and percentiles for sTfR and the ratio of sTfR to log-ferritin (sTfR-F index) using a standard immunoturbidimetric assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2024-0369_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Soluble TfR levels were highly age-specific, with a peak in infancy and a decline in adulthood, whereas the sTfR-F index was a rather constant parameter. There were positive linear relationships for sTfR with hemoglobin (Hb) (p=0.008) and transferrin (females p&lt;0.001; males p=0.003). A\u00a0negative association was observed between sTfR and ferritin in females (p&lt;0.0001) and for transferrin saturation and mean corpuscular volume (MCV) in both sexes (both p&lt;0.0001). We found a positive relationship between sTfR and body height, body mass index (BMI) and inflammatory markers (CrP p&lt;0.0001; WBC p=0.0172), while sTfR-F index was not affected by inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2024-0369_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Soluble TfR values appear to reflect the activity of infant erythropoiesis and to be modulated by inflammation and iron deficiency even in a healthy cohort.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/cclm-2024-0369","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T23:10:57Z","timestamp":1720134657000},"page":"184-192","source":"Crossref","is-referenced-by-count":3,"title":["Reference intervals and percentiles for soluble transferrin receptor and sTfR\/log ferritin index in healthy children and adolescents"],"prefix":"10.1515","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2838-593X","authenticated-orcid":false,"given":"Freerk","family":"Prenzel","sequence":"first","affiliation":[{"name":"Hospital for Children and Adolescents and Center for Pediatric Research (CPL) , 70622 Leipzig University , Leipzig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0523-3113","authenticated-orcid":false,"given":"Thorsten","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Institute for Laboratory Medicine, Microbiology and Pathobiochemistry, University Hospital Ostwestfalen-Lippe (UK-OWL) of Bielefeld University , Detmold , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Willenberg","sequence":"additional","affiliation":[{"name":"70622 Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig , Leipzig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maike","family":"vom Hove","sequence":"additional","affiliation":[{"name":"Hospital for Children and Adolescents and Center for Pediatric Research (CPL) , 70622 Leipzig University , Leipzig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunter","family":"Flemming","sequence":"additional","affiliation":[{"name":"Hospital for Children and Adolescents and Center for Pediatric Research (CPL) , 70622 Leipzig University , Leipzig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Fischer","sequence":"additional","affiliation":[{"name":"Hospital for Children and Adolescents and Center for Pediatric Research (CPL) , 70622 Leipzig University , Leipzig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Kratzsch","sequence":"additional","affiliation":[{"name":"70622 Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig , Leipzig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wieland","family":"Kiess","sequence":"additional","affiliation":[{"name":"Hospital for Children and Adolescents and Center for Pediatric Research (CPL) , 70622 Leipzig University , Leipzig , Germany"},{"name":"LIFE Leipzig Research Center for Civilization Diseases , 70622 University of Leipzig , Leipzig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandy","family":"Vogel","sequence":"additional","affiliation":[{"name":"Hospital for Children and Adolescents and Center for Pediatric Research (CPL) , 70622 Leipzig University , Leipzig , Germany"},{"name":"LIFE Leipzig Research Center for Civilization Diseases , 70622 University of Leipzig , Leipzig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2024,7,8]]},"reference":[{"key":"2025041507391783378_j_cclm-2024-0369_ref_001","doi-asserted-by":"crossref","unstructured":"Srole, DN, Ganz, T. 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