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Cardiac troponin I (cTnI) and cardiac troponin T (cTnT) are widely recognized biomarkers of cardiomyocyte injury and the gold-standard biomarkers for diagnosing myocardial infarction (MI). High-sensitivity cardiac troponin (hs-cTn) assays have the ability to accurately detect low cTn concentrations and document minor increases. However, in addition to MI, various other pathophysiological states can trigger elevated cardiac troponin levels, thus creating potential challenges in the diagnostic process. As cTn released into the bloodstream exists in heterogeneous forms, improving our understanding and accurately characterizing these forms across various etiologies might hold clinical significance. In this review, we add to the field by offering an overview of research on possible circulating forms of cTn, the mechanisms of cTn elevation, and the clinical significance of cTn following conditions such as MI, endurance exercise, and chronic kidney disease, thus highlighting the importance and challenge of understanding of the circulating forms of cTn and possible strategies for cTn immunodetection.<\/jats:p>","DOI":"10.1515\/cclm-2024-1236","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T04:09:50Z","timestamp":1748318990000},"page":"1667-1681","source":"Crossref","is-referenced-by-count":8,"title":["Understanding the circulating forms of cardiac troponin: insights for clinical practice"],"prefix":"10.1515","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3348-8394","authenticated-orcid":false,"given":"Panpan","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Cardiology , Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Fudan University , Shanghai , P.R. China"},{"name":"Department of Clinical Laboratory , Minhang Hospital, Fudan University , Shanghai , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology , Minhang Hospital, Fudan University , Shanghai , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiang","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Cardiology , Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Fudan University , Shanghai , P.R. China"},{"name":"National Clinical Research Center for Interventional Medicine , Shanghai , P.R. China"},{"name":"State Key Laboratory of Cardiovascular Diseases , Zhongshan Hospital, Fudan University , Shanghai , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbo","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Cardiology , Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Fudan University , Shanghai , P.R. China"},{"name":"National Clinical Research Center for Interventional Medicine , Shanghai , P.R. China"},{"name":"State Key Laboratory of Cardiovascular Diseases , Zhongshan Hospital, Fudan University , Shanghai , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"2026051215061122721_j_cclm-2024-1236_ref_001","doi-asserted-by":"crossref","unstructured":"Makam, AN, Nguyen, OK. Use of cardiac biomarker testing in the emergency department. JAMA Intern Med 2015;175:67\u201375. https:\/\/doi.org\/10.1001\/jamainternmed.2014.5830.","DOI":"10.1001\/jamainternmed.2014.5830"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_002","doi-asserted-by":"crossref","unstructured":"Byrne, RA, Rossello, X, Coughlan, JJ, Barbato, E, Berry, C, Chieffo, A, et al.. 2023 ESC Guidelines for the management of acute coronary syndromes. Eur Heart J 2023;44:3720\u2013826. https:\/\/doi.org\/10.1093\/eurheartj\/ehad191.","DOI":"10.1093\/eurheartj\/ehad191"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_003","doi-asserted-by":"crossref","unstructured":"Thygesen, K, Alpert, JS, Jaffe, AS, Chaitman, BR, Bax, JJ, Morrow, DA, et al.. Fourth universal definition of myocardial infarction (2018). Eur Heart J 2019;40:237\u201369. https:\/\/doi.org\/10.1093\/eurheartj\/ehy462.","DOI":"10.1093\/eurheartj\/ehy462"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_004","doi-asserted-by":"crossref","unstructured":"De Lemos, JA. Increasingly sensitive assays for cardiac troponins: a review. JAMA 2013;309:2262\u20139. https:\/\/doi.org\/10.1001\/jama.2013.5809.","DOI":"10.1001\/jama.2013.5809"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_005","doi-asserted-by":"crossref","unstructured":"Thygesen, K, Mair, J, Giannitsis, E, Mueller, C, Lindahl, B, Blankenberg, S, et al.. How to use high-sensitivity cardiac troponins in acute cardiac care. Eur Heart J 2012;33:2252\u20137. https:\/\/doi.org\/10.1093\/eurheartj\/ehs154.","DOI":"10.1093\/eurheartj\/ehs154"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_006","doi-asserted-by":"crossref","unstructured":"Tibaut, M, Caprnda, M, Kubatka, P, Sinkovi\u010d, A, Valentova, V, Filipova, S, et al.. Markers of atherosclerosis: part 1\u00a0\u2013\u00a0serological markers. Heart Lung Circ 2019;28:667\u201377. https:\/\/doi.org\/10.1016\/j.hlc.2018.06.1057.","DOI":"10.1016\/j.hlc.2018.06.1057"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_007","doi-asserted-by":"crossref","unstructured":"De Lemos, JA, DeFilippi, CR. Prevalence and significance of detectable troponins as measured by highly sensitive assays in the general population. Coron Artery Dis 2013;24:705\u20139. https:\/\/doi.org\/10.1097\/mca.0000000000000048.","DOI":"10.1097\/MCA.0000000000000048"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_008","doi-asserted-by":"crossref","unstructured":"Saunders, JT, Nambi, V, De Lemos, JA, Chambless, LE, Virani, SS, Boerwinkle, E, et al.. Cardiac troponin T measured by a highly sensitive assay predicts coronary heart disease, heart failure, and mortality in the atherosclerosis risk in communities study. Circulation 2011;123:1367\u201376. https:\/\/doi.org\/10.1161\/circulationaha.110.005264.","DOI":"10.1161\/CIRCULATIONAHA.110.005264"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_009","doi-asserted-by":"crossref","unstructured":"Lyon, AR, Lopez-Fernandez, T, Couch, LS, Asteggiano, R, Aznar, MC, Bergler-Klein, J, et al.. 2022 ESC guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS). Eur Heart J 2022;43:4229\u2013361. https:\/\/doi.org\/10.1093\/eurheartj\/ehac244.","DOI":"10.1093\/eurheartj\/ehac244"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_010","doi-asserted-by":"crossref","unstructured":"Wu, AHB, Christenson, RH, Greene, DN, Jaffe, AS, Kavsak, PA, Ordonez-Llanos, J, et al.. Clinical laboratory practice recommendations for the use of cardiac troponin in acute coronary syndrome: expert opinion from the Academy of the American Association for Clinical Chemistry and the Task Force on Clinical Applications of Cardiac Bio-Markers of the International Federation of Clinical Chemistry and Laboratory Medicine. Clin Chem 2018;64:645\u201355. https:\/\/doi.org\/10.1373\/clinchem.2017.277186.","DOI":"10.1373\/clinchem.2017.277186"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_011","unstructured":"Klinkenberg, LJJ. High-sensitivity cardiac troponins in health and disease. Ned Tijdschr Klin Chem Labgeneesk 2016;41:235\u201341."},{"key":"2026051215061122721_j_cclm-2024-1236_ref_012","doi-asserted-by":"crossref","unstructured":"Giannitsis, E, Katus, HA. Cardiac troponin level elevations not related to acute coronary syndromes. Nat Rev Cardiol 2013;10:623\u201334. https:\/\/doi.org\/10.1038\/nrcardio.2013.129.","DOI":"10.1038\/nrcardio.2013.129"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_013","doi-asserted-by":"crossref","unstructured":"Streng, AS, De Boer, D, Van Doorn, WP, Kocken, JM, Bekers, O, Wodzig, WK. Cardiac troponin T degradation in serum is catalysed by human thrombin. Biochem Biophys Res Commun 2016;481:165\u20138. https:\/\/doi.org\/10.1016\/j.bbrc.2016.10.149.","DOI":"10.1016\/j.bbrc.2016.10.149"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_014","doi-asserted-by":"crossref","unstructured":"Katrukha, IA, Kogan, AE, Vylegzhanina, AV, Serebryakova, MV, Koshkina, EV, Bereznikova, AV, et al.. Thrombin-Mediated degradation of human cardiac troponin T. 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Purification and properties of a tropomyosin-containing protein fraction that sensitizes reconstituted actomyosin to calcium-binding agents. J\u00a0Biol Chem 1966;241:1522\u20139. https:\/\/doi.org\/10.1016\/s0021-9258(18)96743-8.","DOI":"10.1016\/S0021-9258(18)96743-8"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_028","doi-asserted-by":"crossref","unstructured":"Ebashi, S. Third component participating in the super precipitation of \u2018natural actomyosin\u2019. Nature 1963;200:1010. https:\/\/doi.org\/10.1038\/2001010a0.","DOI":"10.1038\/2001010a0"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_029","doi-asserted-by":"crossref","unstructured":"Bowman, JD, Lindert, S. Computational studies of cardiac and skeletal troponin. 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Lack of identity of tropocalcin with troponin components. Biochem Biophys Res Commun 1972;48:358\u201361. https:\/\/doi.org\/10.1016\/s0006-291x(72)80058-5.","DOI":"10.1016\/S0006-291X(72)80058-5"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_033","doi-asserted-by":"crossref","unstructured":"Ebashi, S, Ebashi, F, Kodama, A. Troponin as the Ca++-receptive protein in the contractile system. J\u00a0Biochem 1967;62:137\u20138. https:\/\/doi.org\/10.1093\/oxfordjournals.jbchem.a128628.","DOI":"10.1093\/oxfordjournals.jbchem.a128628"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_034","doi-asserted-by":"crossref","unstructured":"Greaser, ML, Gergely, J. Reconstitution of troponin activity from three protein components. J\u00a0Biol Chem 1971;246:4226\u201333. https:\/\/doi.org\/10.1016\/s0021-9258(18)62075-7.","DOI":"10.1016\/S0021-9258(18)62075-7"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_035","doi-asserted-by":"crossref","unstructured":"Farah, CS, Reinach, FC. The troponin complex and regulation of muscle contraction. FASEB J 1995;9:755\u201367. https:\/\/doi.org\/10.1096\/fasebj.9.9.7601340.","DOI":"10.1096\/fasebj.9.9.7601340"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_036","doi-asserted-by":"crossref","unstructured":"Takeda, S, Yamashita, A, Maeda, K, Maeda, Y. Structure of the core domain of human cardiac troponin in the Ca2+-saturated form. Nature 2003;424:35\u201341. https:\/\/doi.org\/10.1038\/nature01780.","DOI":"10.1038\/nature01780"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_037","doi-asserted-by":"crossref","unstructured":"Li, MX, Hwang, PM. Structure and function of cardiac troponin C (TNNC1): implications for heart failure, cardiomyopathies, and troponin modulating drugs. 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Annu Rev Physiol 2005;67:39\u201367. https:\/\/doi.org\/10.1146\/annurev.physiol.67.040403.114025.","DOI":"10.1146\/annurev.physiol.67.040403.114025"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_040","doi-asserted-by":"crossref","unstructured":"Cai, F, Li, MX, Pineda-Sanabria, SE, Gelozia, S, Lindert, S, West, F, et al.. Structures reveal details of small molecule binding to cardiac troponin. J\u00a0Mol Cell Cardiol 2016;101:134\u201344. https:\/\/doi.org\/10.1016\/j.yjmcc.2016.10.016.","DOI":"10.1016\/j.yjmcc.2016.10.016"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_041","doi-asserted-by":"crossref","unstructured":"Marston, S, Zamora, JE. Troponin structure and function: a view of recent progress. J\u00a0Muscle Res Cell Motil 2020;41:71\u201389. https:\/\/doi.org\/10.1007\/s10974-019-09513-1.","DOI":"10.1007\/s10974-019-09513-1"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_042","doi-asserted-by":"crossref","unstructured":"Parmacek, MS, Solaro, RJ. Biology of the troponin complex in cardiac myocytes. Prog Cardiovasc Dis 2004;47:159\u201376. https:\/\/doi.org\/10.1016\/j.pcad.2004.07.003.","DOI":"10.1016\/j.pcad.2004.07.003"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_043","doi-asserted-by":"crossref","unstructured":"De Lavallaz, JDF, Zehntner, T, Puelacher, C, Walter, J, Strebel, I, Rentsch, K, et al.. Rhabdomyolysis: a noncardiac source of increased circulating concentrations of cardiac troponin T? J\u00a0Am Coll Cardiol 2018;72:2936\u20137. https:\/\/doi.org\/10.1016\/j.jacc.2018.09.050.","DOI":"10.1016\/j.jacc.2018.09.050"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_044","doi-asserted-by":"crossref","unstructured":"Weil, BR, Suzuki, G, Young, RF, Iyer, V, Canty, JM. Troponin release and reversible left ventricular dysfunction after transient pressure overload. 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Multi-site coronary vein sampling study on cardiac troponin T degradation in non-ST-segment-elevation myocardial infarction: toward a more specific cardiac troponin T assay. J\u00a0Am Heart Assoc 2019;8:e012602. https:\/\/doi.org\/10.1161\/jaha.119.012602.","DOI":"10.1161\/JAHA.119.012602"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_051","doi-asserted-by":"crossref","unstructured":"Cardinaels, EP, Mingels, AM, van Rooij, T, Collinson, PO, Prinzen, FW, van Dieijen-Visser, MP. Time-dependent degradation pattern of cardiac troponin T following myocardial infarction. Clin Chem 2013;59:1083\u201390. https:\/\/doi.org\/10.1373\/clinchem.2012.200543.","DOI":"10.1373\/clinchem.2012.200543"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_052","doi-asserted-by":"crossref","unstructured":"Damen, SAJ, Cramer, GE, Dieker, HJ, Gehlmann, H, Ophuis, T, Aengevaeren, WRM, et al.. Cardiac troponin composition characterization after non ST-elevation myocardial infarction: relation with culprit artery, ischemic time window, and severity of injury. Clin Chem 2021;67:227\u201336. https:\/\/doi.org\/10.1093\/clinchem\/hvaa231.","DOI":"10.1093\/clinchem\/hvaa231"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_053","doi-asserted-by":"crossref","unstructured":"Michielsen, EC, Diris, JH, Kleijnen, VW, Wodzig, WK, Van Dieijen-Visser, MP. Investigation of release and degradation of cardiac troponin T in patients with acute myocardial infarction. Clin Biochem 2007;40:851\u20135. https:\/\/doi.org\/10.1016\/j.clinbiochem.2007.04.004.","DOI":"10.1016\/j.clinbiochem.2007.04.004"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_054","doi-asserted-by":"crossref","unstructured":"Streng, AS, de Boer, D, van Doorn, WP, Bouwman, FG, Mariman, EC, Bekers, O, et al.. Identification and characterization of cardiac troponin T fragments in serum of patients suffering from acute myocardial infarction. Clin Chem 2017;63:563\u201372. https:\/\/doi.org\/10.1373\/clinchem.2016.261511.","DOI":"10.1373\/clinchem.2016.261511"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_055","doi-asserted-by":"crossref","unstructured":"Chaulin, AM. Biology of cardiac troponins: emphasis on metabolism. Biology (Basel). 2022;11:429. https:\/\/doi.org\/10.3390\/biology11030429.","DOI":"10.3390\/biology11030429"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_056","doi-asserted-by":"crossref","unstructured":"McDonough, JL, Arrell, DK, Van Eyk, JE. Troponin I degradation and covalent complex formation accompanies myocardial ischemia\/reperfusion injury. 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Clin Chem 2017;63:1768\u20139. https:\/\/doi.org\/10.1373\/clinchem.2017.279182.","DOI":"10.1373\/clinchem.2017.279182"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_059","doi-asserted-by":"crossref","unstructured":"Madsen, LH, Christensen, G, Lund, T, Serebruany, VL, Granger, CB, Hoen, I, et al.. Time course of degradation of cardiac troponin I in patients with acute ST-elevation myocardial infarction: the ASSENT-2 troponin substudy. Circ Res 2006;99:1141\u20137. https:\/\/doi.org\/10.1161\/01.res.0000249531.23654.e1.","DOI":"10.1161\/01.RES.0000249531.23654.e1"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_060","doi-asserted-by":"crossref","unstructured":"Welsh, P, Preiss, D, Hayward, C, Shah, ASV, McAllister, D, Briggs, A, et al.. Cardiac troponin T and troponin I in the general population. Circulation 2019;139:2754\u201364. https:\/\/doi.org\/10.1161\/circulationaha.118.038529.","DOI":"10.1161\/CIRCULATIONAHA.118.038529"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_061","doi-asserted-by":"crossref","unstructured":"van der Linden, N, Klinkenberg, LJJ, Bekers, O, Loon, L, Dieijen-Visser, MPV, Zeegers, MP, et al.. Prognostic value of basal high-sensitive cardiac troponin levels on mortality in the general population: a meta-analysis. Medicine (Baltim) 2016;95:e5703. https:\/\/doi.org\/10.1097\/md.0000000000005703.","DOI":"10.1097\/MD.0000000000005703"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_062","doi-asserted-by":"crossref","unstructured":"Eggers, KM, Hammarsten, O, Lindahl, B. Differences between high-sensitivity cardiac troponin T and I in stable populations: underlying causes and clinical implications. Clin Chem Lab Med 2023;61:380\u20137. https:\/\/doi.org\/10.1515\/cclm-2022-0778.","DOI":"10.1515\/cclm-2022-0778"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_063","doi-asserted-by":"crossref","unstructured":"Collinson, PO, Boa, FG, Gaze, DC. Measurement of cardiac troponins. Ann Clin Biochem 2001;38:423\u201349. https:\/\/doi.org\/10.1177\/000456320103800501.","DOI":"10.1177\/000456320103800501"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_064","doi-asserted-by":"crossref","unstructured":"Gaze, DC, Collinson, PO. Multiple molecular forms of circulating cardiac troponin: analytical and clinical significance. Ann Clin Biochem 2008;45:349\u201355. https:\/\/doi.org\/10.1258\/acb.2007.007229.","DOI":"10.1258\/acb.2007.007229"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_065","doi-asserted-by":"crossref","unstructured":"Giannitsis, E, Kurz, K, Hallermayer, K, Jarausch, J, Jaffe, AS, Katus, HA. Analytical validation of a high-sensitivity cardiac troponin T assay. Clin Chem 2010;56:254\u201361. https:\/\/doi.org\/10.1373\/clinchem.2009.132654.","DOI":"10.1373\/clinchem.2009.132654"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_066","doi-asserted-by":"crossref","unstructured":"De Boer, D, Streng, AS, Van Doorn, W, Vroemen, WHM, Bekers, O, Wodzig, W, et al.. Cardiac troponin T: the impact of posttranslational modifications on analytical immunoreactivity in blood up to the excretion in urine. Adv Exp Med Biol 2021;1306:41\u201359. https:\/\/doi.org\/10.1007\/978-3-030-63908-2_4.","DOI":"10.1007\/978-3-030-63908-2_4"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_067","doi-asserted-by":"crossref","unstructured":"Van Doorn, WPTM, Vroemen, WHM, De Boer, D, Mingels, AMA, Bekers, O, Wodzig, WKWH, et al.. Clinical laboratory practice recommendations for high-sensitivity cardiac troponin testing. J\u00a0Lab Precis Med 2018;3:30. https:\/\/doi.org\/10.21037\/jlpm.2018.03.09.","DOI":"10.21037\/jlpm.2018.03.09"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_068","doi-asserted-by":"crossref","unstructured":"DeFilippi, C, Seliger, S. The cardiac troponin renal disease diagnostic conundrum: past, present, and future. Circulation 2018;137:452\u20134. https:\/\/doi.org\/10.1161\/circulationaha.117.031717.","DOI":"10.1161\/CIRCULATIONAHA.117.031717"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_069","doi-asserted-by":"crossref","unstructured":"Katrukha, IA, Katrukha, AG. Myocardial injury and the release of troponins I and T in the blood of patients. Clin Chem 2021;67:124\u201330. https:\/\/doi.org\/10.1093\/clinchem\/hvaa281.","DOI":"10.1093\/clinchem\/hvaa281"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_070","doi-asserted-by":"crossref","unstructured":"Katrukha, AG, Bereznikova, AV, Filatov, VL, Esakova, TV, Kolosova, OV, Pettersson, K, et al.. Degradation of cardiac troponin I: implication for reliable immunodetection. Clin Chem 1998;44:2433\u201340. https:\/\/doi.org\/10.1093\/clinchem\/44.12.2433.","DOI":"10.1093\/clinchem\/44.12.2433"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_071","doi-asserted-by":"crossref","unstructured":"Panteghini, MGW, Apple, FS, Dati, F, Ravkilde, J, Wu, AH. Quality specifications for cardiac troponin assays. International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). Clin Chem Lab Med 2001;39:175\u20139. https:\/\/doi.org\/10.1515\/cclm.2001.39.2.175.","DOI":"10.1515\/cclm.2001.39.2.175"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_072","doi-asserted-by":"crossref","unstructured":"Tate, JR, Bunk, DM, Christenson, RH, Barth, JH, Katrukha, A, Noble, JE, et al.. Evaluation of standardization capability of current cardiac troponin I assays by a correlation study: results of an IFCC pilot project. Clin Chem Lab Med 2015;53:677\u201390. https:\/\/doi.org\/10.1515\/cclm-2014-1197.","DOI":"10.1515\/cclm-2014-1197"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_073","doi-asserted-by":"crossref","unstructured":"Labugger, R, Organ, L, Collier, C, Atar, D, Van Eyk, JE. Extensive troponin I and T modification detected in serum from patients with acute myocardial infarction. Circulation 2000;102:1221\u20136. https:\/\/doi.org\/10.1161\/01.cir.102.11.1221.","DOI":"10.1161\/01.CIR.102.11.1221"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_074","doi-asserted-by":"crossref","unstructured":"McDonough, JL, Labugger, R, Pickett, W, Tse, MY, MacKenzie, S, Pang, SC, et al.. Cardiac troponin I is modified in the myocardium of bypass patients. Circulation 2001;103:58\u201364. https:\/\/doi.org\/10.1161\/01.cir.103.1.58.","DOI":"10.1161\/01.CIR.103.1.58"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_075","doi-asserted-by":"crossref","unstructured":"Mingels, AM, Cobbaert, CM, de Jong, N, van den Hof, WF, van Dieijen-Visser, MP. Time- and temperature-dependent stability of troponin standard reference material 2921 in serum and plasma. Clin Chem Lab Med 2012;50:1681\u20134. https:\/\/doi.org\/10.1515\/cclm-2011-1851.","DOI":"10.1515\/cclm-2011-1851"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_076","doi-asserted-by":"crossref","unstructured":"Streng, AS, de Boer, D, Bouwman, FG, Mariman, EC, Scholten, A, van Dieijen-Visser, MP, et al.. Development of a targeted selected ion monitoring assay for the elucidation of protease induced structural changes in cardiac troponin T. J\u00a0Proteomics 2016;136:123\u201332. https:\/\/doi.org\/10.1016\/j.jprot.2015.12.028.","DOI":"10.1016\/j.jprot.2015.12.028"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_077","doi-asserted-by":"crossref","unstructured":"Katrukha, IA, Riabkova, NS, Kogan, AE, Vylegzhanina, AV, Mukharyamova, KS, Bogomolova, AP, et al.. Fragmentation of human cardiac troponin T after acute myocardial infarction. Clin Chim Acta 2023;542:117281. https:\/\/doi.org\/10.1016\/j.cca.2023.117281.","DOI":"10.1016\/j.cca.2023.117281"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_078","doi-asserted-by":"crossref","unstructured":"Denessen, EJS, Vroemen, WHM, Litjens, EJR, Henskens, YMC, van der Sande, FM, Bekers, O, et al.. Cardiac troponin T degradation in end-stage renal disease patients appears to occur in\u00a0vivo. J\u00a0Appl Lab Med 2023;8:1000\u20132. https:\/\/doi.org\/10.1093\/jalm\/jfad043.","DOI":"10.1093\/jalm\/jfad043"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_079","doi-asserted-by":"crossref","unstructured":"Dubin, RF, Li, Y, He, J, Jaar, BG, Kallem, R, Lash, JP, et al.. Predictors of high sensitivity cardiac troponin T in chronic kidney disease patients: a cross-sectional study in the chronic renal insufficiency cohort (CRIC). BMC Nephrol 2013;14:229. https:\/\/doi.org\/10.1186\/1471-2369-14-229.","DOI":"10.1186\/1471-2369-14-229"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_080","doi-asserted-by":"crossref","unstructured":"Pfortmueller, CA, Funk, GC, Marti, G, Leichtle, AB, Fiedler, GM, Schwarz, C, et al.. Diagnostic performance of high-sensitive troponin T in patients with renal insufficiency. 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Am J Emerg Med 2021;46:170\u20135. https:\/\/doi.org\/10.1016\/j.ajem.2020.06.072.","DOI":"10.1016\/j.ajem.2020.06.072"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_083","doi-asserted-by":"crossref","unstructured":"Murphy, D, Firoozi, S, Herzog, CA, Banerjee, D. Cardiac troponin, kidney function, heart failure and mortality after myocardial infarction in patients with and without kidney impairment. Am J Cardiol 2023;204:383\u201391. https:\/\/doi.org\/10.1016\/j.amjcard.2023.07.106.","DOI":"10.1016\/j.amjcard.2023.07.106"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_084","doi-asserted-by":"crossref","unstructured":"Twerenbold, R, Badertscher, P, Boeddinghaus, J, Nestelberger, T, Wildi, K, Puelacher, C, et al.. 0\/1-hour triage algorithm for myocardial infarction in patients with renal dysfunction. 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Clin Chem 2016;62:631\u20138. https:\/\/doi.org\/10.1373\/clinchem.2015.251835.","DOI":"10.1373\/clinchem.2015.251835"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_087","doi-asserted-by":"crossref","unstructured":"deFilippi, C, Seliger, SL, Kelley, W, Duh, SH, Hise, M, Christenson, RH, et al.. Interpreting cardiac troponin results from high-sensitivity assays in chronic kidney disease without acute coronary syndrome. Clin Chem 2012;58:1342\u201351. https:\/\/doi.org\/10.1373\/clinchem.2012.185322.","DOI":"10.1373\/clinchem.2012.185322"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_088","doi-asserted-by":"crossref","unstructured":"Schiffrin, EL, Lipman, ML, Mann, JF. Chronic kidney disease: effects on the cardiovascular system. Circulation 2007;116:85\u201397. https:\/\/doi.org\/10.1161\/circulationaha.106.678342.","DOI":"10.1161\/CIRCULATIONAHA.106.678342"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_089","doi-asserted-by":"crossref","unstructured":"Freda, BJ, Tang, WH, Van Lente, F, Peacock, WF, Francis, GS. Cardiac troponins in renal insufficiency: review and clinical implications. J\u00a0Am Coll Cardiol 2002;40:2065\u201371. https:\/\/doi.org\/10.1016\/s0735-1097(02)02608-6.","DOI":"10.1016\/S0735-1097(02)02608-6"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_090","doi-asserted-by":"crossref","unstructured":"Sharma, R, Gaze, DC, Pellerin, D, Mehta, RL, Gregson, H, Streather, CP, et al.. Cardiac structural and functional abnormalities in end stage renal disease patients with elevated cardiac troponin T. Heart 2006;92:804\u20139. https:\/\/doi.org\/10.1136\/hrt.2005.069666.","DOI":"10.1136\/hrt.2005.069666"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_091","doi-asserted-by":"crossref","unstructured":"Breidthardt, T, Burton, JO, Odudu, A, Eldehni, MT, Jefferies, HJ, McIntyre, CW. Troponin T for the detection of dialysis-induced myocardial stunning in hemodialysis patients. Clin J Am Soc Nephrol 2012;7:1285\u201392. https:\/\/doi.org\/10.2215\/cjn.00460112.","DOI":"10.2215\/CJN.00460112"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_092","doi-asserted-by":"crossref","unstructured":"Bansal, N, Anderson, AH, Yang, W, Christenson, RH, DeFilippi, CR, Deo, R, et al.. High-sensitivity troponin T and N-terminal pro-B-type natriuretic peptide (NT-proBNP) and risk of incident heart failure in patients with CKD. J\u00a0Am Soc Nephrol 2015;26:946\u201356.","DOI":"10.1681\/ASN.2014010108"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_093","doi-asserted-by":"crossref","unstructured":"Apple, FS, Murakami, MM, Pearce, LA, Herzog, CA. Predictive value of cardiac troponin I and T for subsequent death in end-stage renal disease. Circulation 2002;106:2941\u20135. https:\/\/doi.org\/10.1161\/01.cir.0000041254.30637.34.","DOI":"10.1161\/01.CIR.0000041254.30637.34"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_094","doi-asserted-by":"crossref","unstructured":"Hassan, HC, Howlin, K, Jefferys, A, Spicer, ST, Aravindan, AN, Suryanarayanan, G, et al.. High-sensitivity troponin as a predictor of cardiac events and mortality in the stable dialysis population. 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Am Heart J 2006;151:654\u201360. https:\/\/doi.org\/10.1016\/j.ahj.2005.05.014.","DOI":"10.1016\/j.ahj.2005.05.014"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_161","doi-asserted-by":"crossref","unstructured":"Apple, FS, Sandoval, Y, Jaffe, AS, Ordonez-Llanos, J. IFCC Task Force on Clinical Applications of Cardiac Bio-Markers. Cardiac troponin assays: guide to understanding analytical characteristics and their impact on clinical care. Clin Chem 2017;63:73\u201381. https:\/\/doi.org\/10.1373\/clinchem.2016.255109.","DOI":"10.1373\/clinchem.2016.255109"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_162","doi-asserted-by":"crossref","unstructured":"Panteghini, M, Bonora, R, Pagani, F, Buffoli, F, Cuccia, C. Rapid, highly sensitive immunoassay for determination of cardiac troponin I in patients with myocardial cell damage. Clin Chem 1997;43:1464\u20135. https:\/\/doi.org\/10.1093\/clinchem\/43.8.1464.","DOI":"10.1093\/clinchem\/43.8.1464"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_163","doi-asserted-by":"crossref","unstructured":"Lam, L, Aspin, L, Heron, RC, Ha, L, Kyle, C. Discrepancy between cardiac troponin assays due to endogenous antibodies. Clin Chem 2020;66:445\u201354. https:\/\/doi.org\/10.1093\/clinchem\/hvz032.","DOI":"10.1093\/clinchem\/hvz032"},{"key":"2026051215061122721_j_cclm-2024-1236_ref_164","doi-asserted-by":"crossref","unstructured":"Hammarsten, O, Becker, C, Engberg, AE. Methods for analyzing positive cardiac troponin assay interference. 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