{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:20:10Z","timestamp":1790997610893,"version":"4.1.0"},"reference-count":33,"publisher":"Walter de Gruyter GmbH","issue":"9","funder":[{"DOI":"10.13039\/501100017577","name":"Basic Public Welfare Research Program of Zhejiang Province","doi-asserted-by":"publisher","award":["LGF22H160018"],"award-info":[{"award-number":["LGF22H160018"]}],"id":[{"id":"10.13039\/501100017577","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Science and Technology Project of Jiaxing City","award":["2020AD30054"],"award-info":[{"award-number":["2020AD30054"]}]},{"name":"Jiaxing Key Discipiline of Medcine -- Clinical diagnostics","award":["2023-ZC-002"],"award-info":[{"award-number":["2023-ZC-002"]}]},{"name":"Medical and Health Science and Technology Program of Zhejiang Province","award":["2023KY331"],"award-info":[{"award-number":["2023KY331"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_cclm-2024-1510_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>In the early stage of gastric cancer (GC), identifying cancer-specific biomarkers is a key step in the disease screening process. This study aims to explore the clinical value of five novel protein biomarkers and their combination (5\u202fMP) for GC early diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2024-1510_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The candidate biomarkers were mined from TCGA, GTEx, and CPTAC databases. The clinical value of the five biomarkers and 5\u202fMP in the early diagnosis from healthy control, benign gastric disease (BGD), precancerous lesions (PLGC), early GC (EGC), and GC was evaluated by receiver operator characteristic curve (ROC), the area under the curve (AUC), sensitivity, specificity, and accuracy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2024-1510_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Five candidate biomarkers, COL10A1, GKN1, GKN2, LIPF, and REG4, were mined from TCGA, GTEx, and CPTAC databases. In the training cohort, the five proteins were confirmed to be differentially expressed in the serum of control, BGD, EGC, and GC. COL10A1 has the highest AUC of a single protein in control vs. EGC (0.857). GKN2 has the highest AUC of a single protein in BGD vs. EGC (0.822). 5\u202fMP has an AUC of 0.890 in Control vs. EGC, and 0.854 in BGD vs. EGC. In the validation cohort, 5\u202fMP has an AUC of 0.834 in PLGC vs. GC, and 0.839 in PLGC vs.\u00a0EGC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2024-1510_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest that COL10A1, GKN1, GKN2, LIPF, and REG4 are useful non-invasive serum biomarkers for GC diagnosis. Combination detection (5\u202fMP) has enhanced early diagnosis of GC and distinguishing between benign and malignant gastric diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/cclm-2024-1510","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T11:57:39Z","timestamp":1747828659000},"page":"1864-1875","source":"Crossref","is-referenced-by-count":3,"title":["Promising protein biomarkers for early gastric cancer: clinical performance of combined detection"],"prefix":"10.1515","volume":"63","author":[{"given":"Weifeng","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory , Affiliated Hospital of Jiaxing University , Jiaxing , China"},{"name":"Jiaxing Key Laboratory of Clinical Laboratory Diagnostics and Translational Research, Affiliated Hospital of Jiaxing University , Jiaxing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory , Affiliated Hospital of Jiaxing University , Jiaxing , China"},{"name":"Jiaxing Key Laboratory of Clinical Laboratory Diagnostics and Translational Research, Affiliated Hospital of Jiaxing University , Jiaxing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanqing","family":"Li","sequence":"additional","affiliation":[{"name":"Jiaxing Key Laboratory of Clinical Laboratory Diagnostics and Translational Research, Affiliated Hospital of Jiaxing University , Jiaxing , China"},{"name":"Hangzhou Cosmos Wisdom Mass Spectrometry Center of Zhejiang University Medical School , Hangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiaxing Key Laboratory of Clinical Laboratory Diagnostics and Translational Research, Affiliated Hospital of Jiaxing University , Jiaxing , China"},{"name":"Hangzhou Cosmos Wisdom Mass Spectrometry Center of Zhejiang University Medical School , Hangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinqin","family":"Lou","sequence":"additional","affiliation":[{"name":"Jiaxing Key Laboratory of Clinical Laboratory Diagnostics and Translational Research, Affiliated Hospital of Jiaxing University , Jiaxing , China"},{"name":"Hangzhou Cosmos Wisdom Mass Spectrometry Center of Zhejiang University Medical School , Hangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire Y.","family":"Tong","sequence":"additional","affiliation":[{"name":"Phillips Academy Andover , Boston , MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junshun","family":"Gao","sequence":"additional","affiliation":[{"name":"Jiaxing Key Laboratory of Clinical Laboratory Diagnostics and Translational Research, Affiliated Hospital of Jiaxing University , Jiaxing , China"},{"name":"Hangzhou Cosmos Wisdom Mass Spectrometry Center of Zhejiang University Medical School , Hangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junli","family":"Gao","sequence":"additional","affiliation":[{"name":"Jiaxing Key Laboratory of Clinical Laboratory Diagnostics and Translational Research, Affiliated Hospital of Jiaxing University , Jiaxing , China"},{"name":"Hangzhou Cosmos Wisdom Mass Spectrometry Center of Zhejiang University Medical School , Hangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingyang","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory , Affiliated Hospital of Jiaxing University , Jiaxing , China"},{"name":"Jiaxing Key Laboratory of Clinical Laboratory Diagnostics and Translational Research, Affiliated Hospital of Jiaxing University , Jiaxing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,5,1]]},"reference":[{"key":"2026051215061101358_j_cclm-2024-1510_ref_001","unstructured":"Zheng, R, Chen, R, Han, B, Wang, SM, Li, L, Sun, KX, et al.. 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