{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:34:07Z","timestamp":1793831647452,"version":"4.6.1"},"reference-count":31,"publisher":"Walter de Gruyter GmbH","issue":"8","funder":[{"DOI":"10.13039\/100017981","name":"Sysmex Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017981","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_cclm-2025-0180_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Traditional biomarkers used for sepsis diagnosis have limited sensitivity and specificity and, so far, are not recommended for sepsis diagnosis. We aimed to evaluate diagnostic accuracy of XN-9000\n                      <jats:sup>\u00ae<\/jats:sup>\n                      hematology analyzer derived cell population data (CPD) for sepsis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2025-0180_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a cross-sectional cohort study on patients admitted to an emergency department (ED) with a suspicion of infection, having a complete blood count with differential (CBC-Diff). CBC-Diff were performed on XN-9000\n                      <jats:sup>\u00ae<\/jats:sup>\n                      analyzer (Sysmex, Kobe, Japan). CPD were measured routinely for each CBC-Diff ordered by ED physician. They include: neutrophils-related - Neut-GI and Neut-RI; monocytes-related - Mono-X, Mono-Z, Re-Mono and Mono-Y; IG referring to immature granulocytes; and lymphocytes-related - As-lymp and Re-lymp. Intensive care infection (ICIS) and neutrophile and monocyte (NEMO) scores were calculated using several CPD parameters. Diagnostic performance of each biomarker was computed together with receiver operating characteristic curves for sepsis diagnosis (according to Sepsis-3 definition).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2025-0180_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1,155 patients with a suspicion of infection were included and 230 had sepsis. Median age was 64\u00a0years and 49\u202f% were female. Except for lymphocyte count with an area under the receiver operating characteristic (AUROC) of 0.67 (95\u202f% confidential interval 0.63\u20130.70), the other CPD exhibited modest performances with AUROC under 0.65. The ICIS and NEMO scores had a modest performance with AUROC of 0.56 (0.52\u20130.61) and 0.55 (0.51\u20130.59) respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2025-0180_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>None of the biomarkers and scores tested demonstrated sufficient diagnostic accuracy to be recommended for routine sepsis screening in the\u00a0ED.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/cclm-2025-0180","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T04:01:06Z","timestamp":1744257666000},"page":"1654-1662","source":"Crossref","is-referenced-by-count":6,"title":["Cell population data for early detection of sepsis in patients with suspected infection in the emergency department"],"prefix":"10.1515","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7218-8485","authenticated-orcid":false,"given":"Marta","family":"Cancella De Abreu","sequence":"first","affiliation":[{"name":"Emergency Department , APHP-Sorbonne Universit\u00e9, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re , Paris , France"},{"name":"GRC-14 BIOSFAST, CIMI, Sorbonne Universit\u00e9 , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caren","family":"Brumpt","sequence":"additional","affiliation":[{"name":"Hematology Department , APHP-Sorbonne Universit\u00e9, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timoth\u00e9","family":"Sala","sequence":"additional","affiliation":[{"name":"Emergency Department , APHP-Sorbonne Universit\u00e9, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Oueidat","sequence":"additional","affiliation":[{"name":"Metabolic and Biochemical Department , APHP-Sorbonne Universit\u00e9, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Larsen","sequence":"additional","affiliation":[{"name":"Sorbonne University, Centre D\u2019Immunologie et des Maladies Infectieuses (CIMI Paris) , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Hausfater","sequence":"additional","affiliation":[{"name":"Emergency Department , APHP-Sorbonne Universit\u00e9, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re , Paris , France"},{"name":"GRC-14 BIOSFAST, CIMI, Sorbonne Universit\u00e9 , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,4,11]]},"reference":[{"key":"2026051214261901980_j_cclm-2025-0180_ref_001","doi-asserted-by":"crossref","unstructured":"Singer, M, Deutschman, CS, Seymour, CW, Shankar-Hari, M, Annane, D, Bauer, M, et al.. 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