{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:28:15Z","timestamp":1789810095594,"version":"4.0.1"},"reference-count":4,"publisher":"Walter de Gruyter GmbH","issue":"10","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,25]]},"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n \n The Roche Cobas\n \u00ae<\/jats:sup>\n i601 is a fully automated mass spectrometry analyzer designed for 24\u202fh random-access operation in routine medical laboratories. We aimed to systematically assess its throughput, robustness, and precision\u00a0\u2013\u00a0along with its ease of use and walk-away time\u00a0\u2013\u00a0within a high-volume clinical laboratory setting using the first commercially available reagents.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A panel of 13 measurands, implemented across three different reagent configurations (i pack Ionify\n \u00ae<\/jats:sup>\n reagents: Ionify steroids 1, Ionify steroids 2, Ionify vitamin D 25 and 24,25), was quantified using aliquots of three human serum pools. Identical series layouts were applied across four study days. After loading reagents, consumables, and samples and initiating the respective series, no further operator intervention was required until completion of the\u00a0run.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Across the four series, a total of 3,016 valid quantitative results were generated. Each series was completed within 6\u202fh without operator intervention, corresponding to the minimum observed walk-away time. This equates to an average throughput of 119 analyses per hour. Analysis of the human serum pools demonstrated coefficients of variation (CVs) below 4\u202f% (with few exceptions).<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Under a high-throughput evaluation protocol in a routine clinical laboratory setting, the fully automated MS methods demonstrated performance and productivity characteristics consistent with the manufacturer\u2019s representative data, particularly with regard to calibration stability, precision, analytical throughput, and walk-away\u00a0time.<\/jats:p>\n <\/jats:sec>","DOI":"10.1515\/cclm-2026-0163","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T08:04:32Z","timestamp":1781337872000},"page":"2226-2233","source":"Crossref","is-referenced-by-count":3,"title":["A structured productivity challenge study of a fully automated mass spectrometry system"],"prefix":"10.1515","volume":"64","author":[{"given":"Arber","family":"Rexhaj","sequence":"first","affiliation":[{"name":"Institute of Laboratory Medicine, LMU University Hospital, Ludwig-Maximilians-University , Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5110-346X","authenticated-orcid":false,"given":"Katharina","family":"Habler","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine, LMU University Hospital, Ludwig-Maximilians-University , Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7333-3231","authenticated-orcid":false,"given":"Bernd","family":"Northoff","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine, LMU University Hospital, Ludwig-Maximilians-University , Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Arend","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine, LMU University Hospital, Ludwig-Maximilians-University , Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2745-2475","authenticated-orcid":false,"given":"Michael","family":"Vogeser","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine, LMU University Hospital, Ludwig-Maximilians-University , Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,6,12]]},"reference":[{"key":"2026082718023515322_j_cclm-2026-0163_ref_001","doi-asserted-by":"crossref","unstructured":"Vogeser, M, Zhang, YV. Understanding the strategic landscape surrounding the implementation of mass spectrometry in the clinical laboratory: a SWOT analysis. Clin Mass Spectrom 2018;9:1\u20136. https:\/\/doi.org\/10.1016\/j.clinms.2018.06.001.","DOI":"10.1016\/j.clinms.2018.06.001"},{"key":"2026082718023515322_j_cclm-2026-0163_ref_002","doi-asserted-by":"crossref","unstructured":"Benton, SC, Tetteh, GK, Needham, SJ, M\u00fccke, J, Sheppard, L, Alderson, S, et al.. Evaluation of the 25-hydroxy vitamin D assay on a fully automated liquid chromatography mass spectrometry system, the thermo scientific cascadion SM clinical analyzer with the cascadion 25-hydroxy vitamin D assay in a routine clinical laboratory. Clin Chem Lab Med 2020;58:1010\u20137. https:\/\/doi.org\/10.1515\/cclm-2019-0834.","DOI":"10.1515\/cclm-2019-0834"},{"key":"2026082718023515322_j_cclm-2026-0163_ref_003","doi-asserted-by":"crossref","unstructured":"Vogeser, M, Habler, K, Reuter, A, Schneider-Thauern, C. Research letter: pilot study of a prototype fully automated mass spectrometry system for routine clinical laboratory use. J\u00a0Mass Spectrom Adv Clin Lab 2024;34:44\u20135. https:\/\/doi.org\/10.1016\/j.jmsacl.2024.10.004.","DOI":"10.1016\/j.jmsacl.2024.10.004"},{"key":"2026082718023515322_j_cclm-2026-0163_ref_004","doi-asserted-by":"crossref","unstructured":"Vermeersch, P, de Jonge, R, Miyazawa, T, Nybo, M, Fruekilde, P, Toole, BJ, et al.. Comparison of six serum analyte workflows using routine liquid chromatography-tandem mass spectrometry methods at multiple laboratories with the Cobas i 601 analyzer, an automated mass spectrometry system. Clin Chem Lab Med 2026;26. https:\/\/doi.org\/10.1515\/cclm-2025-0994.","DOI":"10.1515\/cclm-2025-0994"}],"container-title":["Clinical Chemistry and Laboratory Medicine (CCLM)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/cclm-2026-0163\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/cclm-2026-0163\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:04:18Z","timestamp":1787853858000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/cclm-2026-0163\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,12]]},"references-count":4,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,6,8]]},"published-print":{"date-parts":[[2026,9,25]]}},"alternative-id":["10.1515\/cclm-2026-0163"],"URL":"https:\/\/doi.org\/10.1515\/cclm-2026-0163","relation":{},"ISSN":["1434-6621","1437-4331"],"issn-type":[{"value":"1434-6621","type":"print"},{"value":"1437-4331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,12]]}}}