{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T10:58:30Z","timestamp":1793185110669,"version":"4.5.0"},"reference-count":40,"publisher":"Walter de Gruyter GmbH","issue":"7","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A challenge in the implementation of rapid risk-stratification algorithms for patients with suspected acute coronary syndrome is the turnaround time for cardiac troponin (cTn) from blood sampling to reporting of results. Measurement of cTn in whole blood using point of care (POC) offers a solution. There is lack of consensus on how these instruments should be assessed and deployed when implemented into routine practice. A pragmatic strategy is needed to balance the requirement for appropriate evaluation, validation and local verification of POC high sensitivity (hs) cTn assays whilst avoiding unnecessary duplication of previously conducted work using central laboratory assays. The International Federation of Clinical Chemistry and Laboratory Medicine Committee on Clinical Application of Cardiac Bio-Markers (IFCC C-CB) has developed an educational document to provide practical suggestions as to how hs-cTn POC assays may be implemented in acute health care settings and networks. The objective of this document is to provide a pragmatic framework for implementation of such systems. The article describes the validation and verification procedures and outlines what should be the responsibility of the manufacturers and provides recommendations on how a local verification may be undertaken before instruments are implemented into routine clinical practice.<\/jats:p>","DOI":"10.1515\/cclm-2026-0210","type":"journal-article","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T10:18:02Z","timestamp":1772705882000},"page":"1467-1478","source":"Crossref","is-referenced-by-count":5,"title":["Considerations and pragmatic strategies for implementation of point of care testing for high sensitivity cardiac troponin into the acute care setting"],"prefix":"10.1515","volume":"64","author":[{"given":"Paul","family":"Collinson","sequence":"first","affiliation":[{"name":"City St George\u2019s University of London , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Lam","sequence":"additional","affiliation":[{"name":"Pathology, Surgical and Support Services , Te Whatu Ora Health New\u00a0Zealand , Whangarei , New\u00a0Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Pickering","sequence":"additional","affiliation":[{"name":"Department of Medicine , University of Otago Christchurch , Christchurch , New\u00a0Zealand"},{"name":"Emergency Department , Christchurch Hospital , Christchurch , New\u00a0Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Christenson","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Maryland , Baltimore , MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieve","family":"Van Hoovels","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine , AZORG Hospital , Aalst , Belgium"},{"name":"Clinical and Diagnostic Immunology, Department of Microbiology, Immunology and Transplantation , KU Leuven , Leuven , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Jafri","sequence":"additional","affiliation":[{"name":"Aga Khan University , Karachi , Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Cullen","sequence":"additional","affiliation":[{"name":"Emergency and Trauma Centre , Royal Brisbane and Women\u2019s Hospital Health Service , Herston , QLD , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan S.","family":"Jaffe","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine , Mayo Clinic , Rochester , MN , USA"},{"name":"Department of Laboratory Medicine and Pathology , Mayo Clinic , Rochester , MN , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred S.","family":"Apple","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology , University of Minnesota , Minneapolis , MN , USA"},{"name":"Clinical and Forensic Toxicology Laboratory , Hennepin Healthcare\/Hennepin County Medical Center , Minneapolis , MN , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"Hammarsten","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry , Sahlgrenska University Hospital , Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torbj\u00f8rn","family":"Omland","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Division of Medicine , Akershus University Hospital , L\u00f8renskog , Norway"},{"name":"K.G. Jebsen Center for Cardiac Biomarkers, Institute of Clinical Medicine , University of Oslo , Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yader","family":"Sandoval","sequence":"additional","affiliation":[{"name":"Minneapolis Heart Institute , Abbott Northwestern Hospital , Minneapolis , USA"},{"name":"Center for Coronary Artery Disease , Minneapolis Heart Institute Foundation , Minneapolis , MN , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas L.","family":"Mills","sequence":"additional","affiliation":[{"name":"BHF Centre for Cardiovascular Science , University of Edinburgh , Edinburgh , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Than","sequence":"additional","affiliation":[{"name":"Department of Medicine , University of Otago Christchurch , Christchurch , New\u00a0Zealand"},{"name":"Emergency Department , Christchurch Hospital , Christchurch , New\u00a0Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Buchan","sequence":"additional","affiliation":[{"name":"Canterbury Health Laboratories , Christchurch Hospital , Christchurch , New\u00a0Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sverre","family":"Sandberg","sequence":"additional","affiliation":[{"name":"Norwegian Organization for Quality Improvement of Laboratory Examinations (Noklus), Haraldsplass Deaconess Hospital , Bergen , Norway"},{"name":"Norwegian Porphyria Centre, Department of Medical Biochemistry and Pharmacology , Haukeland University Hospital , Bergen , Norway"},{"name":"Department of Global Public Health and Primary Care , University of Bergen , Bergen , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7340-6736","authenticated-orcid":false,"given":"Kristin M.","family":"Aakre","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Pharmacology and Department of Heart Disease , Haukeland University Hospital , Bergen , Norway"},{"name":"Department of Clinical Science , University of Bergen , Bergen , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"key":"2026060518413062406_j_cclm-2026-0210_ref_001","doi-asserted-by":"crossref","unstructured":"Apple, FS, Collinson, PO. 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