{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:17:54Z","timestamp":1783009074570,"version":"3.54.5"},"reference-count":31,"publisher":"Walter de Gruyter GmbH","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_cclm-2026-0236_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Multitarget stool tests are approved for colorectal cancer (CRC) screening. Here we developed a multitarget stool test based on the fecal immunochemical test (FIT) and two (\n                      <jats:italic>NDRG4<\/jats:italic>\n                      and\n                      <jats:italic>SDC2<\/jats:italic>\n                      ) DNA methylation markers with a simple calling algorithm.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2026-0236_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      FIT, quantitative methylation-specific PCR for\n                      <jats:italic>NDRG4<\/jats:italic>\n                      and\n                      <jats:italic>SDC2<\/jats:italic>\n                      were performed for each participant. A score of either 0, 1 or 2 was assigned to each marker as negative, weak positive and positive. A positive test score was called when the score sum for the three biomarkers was at least\u00a02.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2026-0236_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 120 CRC, 23 advanced precancerous lesions (APL) and 308 negative controls (including 59\u00a0non-advanced neoplasia, 26 polyps smaller than 10\u202fmm in size and 223 negative colonoscopy) from two hospitals were enrolled. Age-dependent cut-off values were used for FIT and\n                      <jats:italic>NDRG4<\/jats:italic>\n                      as their levels were positively correlated with age. Sensitivities with the multitarget stool test for CRC and APL were 90.0\u202f% and 65.2\u202f%, respectively, while specificities for participants with negative colonoscopy and absent of advanced neoplasia were 91.0\u202f% and 90.9\u202f%, respectively. We observed a general decline in specificity with more advanced age, which was significantly mitigated by the age-dependent cut-off values.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2026-0236_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The simplified multitarget stool test utilizing age-dependent cut-off values demonstrated promising performance for CRC screening across age groups in the Chinese population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/cclm-2026-0236","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T20:16:55Z","timestamp":1775938615000},"page":"1863-1872","source":"Crossref","is-referenced-by-count":0,"title":["A simplified multitarget stool test for colorectal cancer and advanced precancerous lesion detection"],"prefix":"10.1515","volume":"64","author":[{"given":"Shuizhi","family":"Xu","sequence":"first","affiliation":[{"name":"Key Laboratory of Laboratory Medicine, Ministry of Education of China , School of Laboratory Medicine and Life Sciences, Wenzhou Medical University , Wenzhou , Zhejiang , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisha","family":"Gong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Laboratory Medicine, Ministry of Education of China , School of Laboratory Medicine and Life Sciences, Wenzhou Medical University , Wenzhou , Zhejiang , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibo","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Pathology , Fudan University Shanghai Cancer Center , Shanghai , China"},{"name":"Department of Oncology , Shanghai Medical College, Fudan University , Shanghai , 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J\u00a0Gastrointest Surg 2023;27:2484\u201392. https:\/\/doi.org\/10.1007\/s11605-023-05850-2.","DOI":"10.1007\/s11605-023-05850-2"},{"key":"2026070213034380795_j_cclm-2026-0236_ref_021","doi-asserted-by":"crossref","unstructured":"Halloran, SP, Launoy, G, Zappa, M, International Agency for Research on C. European guidelines for quality assurance in colorectal cancer screening and diagnosis. First edition\u00a0\u2013\u00a0Faecal occult blood testing. Endoscopy 2012;44:SE65\u201387. https:\/\/doi.org\/10.1055\/s-0032-1309791.","DOI":"10.1055\/s-0032-1309791"},{"key":"2026070213034380795_j_cclm-2026-0236_ref_022","doi-asserted-by":"crossref","unstructured":"Rigby, RA, Stasinopoulos, DM. Smooth centile curves for skew and kurtotic data modelled using the Box-Cox power exponential distribution. 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